Increased circulating microRNA-21 level as a potential indicator for predicting a higher risk of incident fragility fractures.

Context: As a common disease in the elderly, osteoporosis clearly increases the risk of fractures, leading to higher mortality, but the current markers to estimate the risk of fractures are limited. MicroRNA-21 (miR-21) may play an important role in osteoporosis, but the link of this biomarker with fractures was undetermined.

Objectives: We aimed to investigate the association between miR-21 levels and the presence of fragility fractures.