Publications by authors named "Zhen-Xin Hu"
CNS Neurosci Ther
November 2023
Article Synopsis
- Spinal cord injury (SCI) leads to significant tissue damage and neurological issues, and the study explores the role of Pregnane X receptor (PXR) in this context.
- Using a mouse model, researchers found that PXR expression decreases after SCI, and knocking out PXR improved motor function while reducing apoptosis, inflammation, and oxidative stress.
- The study suggests that PXR activation hampers recovery by downregulating heme oxygenase-1 (HO-1) and inhibiting the NRF2/HO-1 pathway, showing its crucial role in motor function recovery post-SCI.
