Publications by authors named "Zhen-Sheng Wang"
Article Synopsis
- Small non-coding RNAs, especially microRNAs (miRNAs) and tRNA-derived small RNAs (tsRNAs), play essential roles in gene regulation in Trichomonas vaginalis, the organism responsible for trichomoniasis, but their characteristics had not been fully understood until now.
- Using deep sequencing techniques, researchers identified and confirmed the presence of tsRNAs in T. vaginalis, finding that they are more abundant than miRNAs, which were detected at very low levels.
- This study is the first comprehensive analysis of small RNAs in Trichomonas, revealing three main categories of tsRNAs and insights into their potential function in the organism's biology and disease mechanisms.
Article Synopsis
- Babesiosis, caused by the parasite Babesia microti, is a growing concern as a tick-borne disease, particularly in urban areas like Beijing, where understanding its prevalence in small mammals is key for assessing human exposure risks.
- A study conducted in Beijing from 2014 to 2018 trapped 1,391 small mammals, finding a 12.1% infection rate of B. microti, with different genotypes identified, highlighting specific ecological habitats as risk factors.
- The results signal a widespread presence of B. microti among small mammals and underscore the importance of this information for public health measures aimed at preventing human infections.
A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.
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