Facile synthesis of methotrexate intercalated layered double hydroxides: particle control, structure and bioassay explore.

To study the influence of particle size on drug efficacy and other properties, a series of methotrexate intercalated layered double hydroxides (MTX/LDHs) were synthesized through the traditional coprecipitation method, using a mixture of water and polyethylene glycol (PEG-400) as the solvent. To adjust the particle size of MTX/LDHs, the dropping way, the volume ratio of water to PEG-400 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140 nm. Elemental C/H/N and inductive coupled plasma (ICP) analysis indicated that different synthesis conditions almost have no effect on the compositions of the nanohybrids.

MTX/LDHs hybrids synthesized from reverse microemulsions: particle control and bioassay study.

Reverse microemulsions have been used to control the growth of methotrexatum intercalated layered double hydroxides (MTX/LDHs) hybrids, and the influence of reaction temperature, water content (noted as ω) and MTX content (noted as R) on the properties of MTX/LDHs was systematically investigated. The synthesized hybrids were then characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and atomic force microscopy (AFM), etc. XRD and FTIR investigations manifest the successful intercalation of MTX anions into the interlayer of LDHs.