Degenerate phase-matching for multi-wavelength nonlinear mixing in aperiodic lattice lasers.

Holographically designed aperiodic lattices (ALs) have proven to be an exciting engineering technique for achieving electrically switchable single- or multi-frequency emissions in terahertz (THz) semiconductor lasers. Here, we employ the nonlinear transfer matrix modeling method to investigate multi-wavelength nonlinear (sum- or difference-) frequency generation within an integrated THz (idler) laser cavity that also supports optical (pump and signal) waves. The laser cavity includes an aperiodic lattice, which engineers the idler photon lifetimes and effective refractive indices.

Ectopic endometrial stromal cell-derived extracellular vesicles encapsulating microRNA-25-3p induce endometrial collagen I deposition impairing decidualization in endometriosis.

Endometrial collagen I undergoes dynamic degradation and remodelling in response to endometrial stromal cell (ESC) decidualization and embryo implantation. However, excessive collagen I deposition in the endometrium during the implantation window may impair decidualization, causing embryo implantation failure in patients with endometriosis (EMS). We found that endometrial collagen I expression during the mid-secretory phase was increased in the EMS group of patients.

Therapeutic Effects of Human Placental Extracts Eye Drops in Experimental Dry Eye and Alkali Burn.

To evaluate the efficacy of human placental extract (HPE) eye drops compared to that of carboxymethylcellulose (CMC) and human peripheral blood serum (HPBS) eye drops in a mouse model of experimental dry eye (EDE) and corneal alkali burns. EDE and alkali burn models were induced in C57BL/6 mice using desiccating stress and NaOH, respectively. In both the EDE and alkali burn models, treatment groups received CMC, HPBS, or HPE eye drops.

Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis.

Background: Malnutrition, post-stroke depression (PSD), post-stroke anxiety (PSA), and post-stroke fatigue (PSF) in stroke survivors have complex relationships and are associated with adverse stroke outcomes.

Aims: This research aims to explore the temporal and directional relationships between malnutrition, PSD, PSA, and PSF after stroke in older adults.

Methods: Patients aged 65 years and older with their first ischemic stroke from two centers were selected and assessed at baseline, 3 months and 12 months.

Transcriptome Profiling, Cloning, and Characterization of AnGlu04478, a Ginsenoside Hydrolyzing β-Glucosidase from Aspergillus niger NG1306.

β-Glucosidase plays a pivotal role in transforming ginsenosides into specific minor ginsenosides. In this study, total ginsenosides from Panax notoginseng leaves were used as substrates to stimulate the growth of Aspergillus niger NG1306. Transcriptome analysis identified a β-glucosidase gene, Anglu04478 (1455 bp, 484 amino acids, 54.

A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.

There has been an increase in the incidence and poor prognosis of colorectal cancer in recent years. In several studies, piperine has been shown to inhibit colon cancer cell growth and induce apoptosis. This study aimed to investigate whether a novel piperine-derived compound, HJ-23 (2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4-(2,4-difluorophenyl)piperazin-1-yl)methanone), can effectively inhibit the development of colorectal cancer through specific molecular mechanisms.

Chlorpyrifos Influences Tadpole Development by Disrupting Thyroid Hormone Signaling Pathways.

Chlorpyrifos (CPF) is a widely used organophosphate insecticide with serious toxicological effects on aquatic animals. Although extensively studied for neurotoxicity and endocrine disruption, its stage-specific effects on amphibian metamorphosis and receptor-level interactions remain unclear. This study investigated the effects of CPF on metamorphosis at environmentally relevant concentrations (1.

A novel system for classification for midpalatal suture ossification based on pseudocolored and multilayer reconstructed coronal slices: Indication for selection of maxillary expansion methods.

Introduction: A novel method was established for the staging of midpalatal suture (MPS) ossification based on a pseudocoloring stack of anterior and posterior MPS coronal slices obtained by cone-beam computed tomography (CBCT).

Methods: CBCT scans of 240 subjects aged 5-35 years were pseudocolor processed. The slice thickness of stacked anterior and posterior coronal observation planes was set at 5.

Hydroxyl Spillover in Fe-Se Dual-Site Catalysts for Mixed Plastics Assay.

The complex composition of real plastic wastes poses a significant challenge for their large-scale disposal. A responsive on-site compositional analysis of plastics is informative in choosing downstream processing methods. Nanocatalyst-based assay kit is highly qualified for this scene; however, there remain no efficient nanocatalysts for plastics due to their highly inert chemistry.

Atomically Precise Cu Nanoclusters with Thermally Activated Delayed Fluorescence Properties.

Ligand-stabilized metal nanoclusters with atomic precision are considered to be promising materials in the field of light-emitting and harvesting. Among these, nanoclusters with thermally activated delayed fluorescence (TADF) properties are highly sought after. While several gold and silver nanoclusters with TADF properties have been reported in recent years, research on copper counterparts has significantly lagged behind.

Beneficial effects of EGCG on boar sperm quality during liquid storage at 4 °C are mediated by DRD2 receptor.

Epigallocatechin gallate (EGCG), a natural antioxidant, plays a vital role in modulating sperm function, yet its protective impact on boar spermatozoa during liquid preservation at 4 °C remains elusive. This study aimed to investigate the beneficial effects of EGCG on boar semen preservation, and elucidate the potential mechanism. Multiple parameters including sperm quality, anti-oxidative status, protein phosphorylation levels, membrane receptor and cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathways were analyzed using computer-assisted semen analysis system, Western blot and molecular docking techniques.

Hydrogen bonded organic framework pores differentially loading triazole for photocatalytic uranium reduction.

Using temperature modulation, two distinct hydrogen bond organic frameworks HOF-C and HOF-K with different pore sizes were synthesized from the same ligands, tris(4-(4-1,2,4-triazole-4-yl)phenyl)amine. The pore size difference prevents TRZ from entering HOF-K, while allowing TRZ to selectively insert into the larger-pored HOF-C to form HOF-C-TRZ. The donor-acceptor (D-A) structure formed in HOF-C-TRZ enhances its photoelectric response and exhibits exceptional uranium reduction under visible light irradiation.

Biotransformation analysis of daidzin in vitro based on fecal bacteria and probiotics.

Daidzin, as one of isoflavone glycosides, has been reported to have multiple activities with few absorbed into body. However, the metabolic behavior of daidzin by intestinal flora has not been researched, that this defect severely constrains its applications. In this study, daidzin and its metabolites were qualitatively and quantitatively analyzed by HPLC and ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) in the fermentation system for daidzin and fecal bacteria.

Ovarian tissue cryopreservation for a girl with combined severe hemolytic anemia due to pyruvate kinase deficiency: a case report and literature review.

Objective: To present a young girl with pyruvate kinase deficiency (PKD) and concurrent severe hemolytic anemia who underwent fertility preservation and cryopreservation. Clinical symptoms, diagnosis, treatment, and new strategies for fertility protection and preservation in PKD patients who require allogeneic hematopoietic stem cell therapy are explored.

Case Presentation: Six-year-old girl with persistent unconjugated hyperbilirubinemia and severe hemolytic anemia since birth, continuous elevation of bilirubin levels and severe splenomegaly.

Self-Wrinkling-Induced Mechanically Adaptive Patterned Surface of Photocuring Coating for Abrasion Resistance.

Providing mechanically adaptive performance to surfaces is significant in preserving materials from damage in variable environments, however, it has rarely been studied. Inspired by the mechanically adaptive behaviors of the surface microstructure on the carapace of desert scorpions and bark of desert tamarisks, a self-wrinkled mechanically adaptive patterned surface (SWMAPS) using one-step UV-curing and self-wrinkling technique is reported. Because of the fluorinated polyurethane photo-initiator formed by self-assembly at the top surface, UV-induced photo-crosslinking can spontaneously generate a gradient-crosslinked structure and wrinkled patterns with different morphology.

Association between weight loss and survival outcomes in patients with gastric cancer: a meta-analysis.

Patients with gastric cancer often experience weight loss. A meta-analysis was conducted to evaluate the association between weight loss and survival outcomes in gastric cancer patients. We searched PubMed, Embase, and Web of Science according to the PECOS criteria: population (gastric cancer patients), exposure (weight loss), comparator (weight stable), outcomes [overall survival (OS) or recurrence-free survival], and study design (cohort studies).

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis.

The induction of adipose thermogenesis plays a critical role in maintaining body temperature and improving metabolic homeostasis to combat obesity. β3-adrenoceptor (β3-AR) is widely recognized as a canonical β-adrenergic G-protein-coupled receptor (GPCR) that plays a crucial role in mediating adipose thermogenesis in mice. Nonetheless, the limited expression of β3-AR in human adipocytes restricts its clinical application.

Longitudinal Efficacy of Nusinersen Treatment on Health-Related Quality of Life and Independence in Children With Later-Onset Spinal Muscular Atrophy.

Introduction/aims: The rising use of disease-modifying therapy is progressively impacting the health-related quality of life (HRQoL) of patients with spinal muscular atrophy (SMA) in their daily lives. This study aimed to evaluate the changes in HRQoL and independence in children with later-onset SMA receiving longitudinal treatment with nusinersen.

Methods: Forty-nine pediatric patients with later-onset SMA (symptom onset after 6 months of age) and their caregivers were enrolled.

Comparative Analysis of Central and Noncentral Degenerative Mitral Regurgitation Treated With Transcatheter Mitral Valve Edge-To-Edge Repair.

Background: Mitral valve transcatheter edge-to-edge repair (M-TEER) was initially indicated for central degenerative mitral regurgitation (DMR) lesions, but advancements in technology have enabled successful treatment in an increasing number of noncentral DMR patients.

Aims: This study aims to compare procedural outcomes and prognosis between noncentral DMR patients, outside clinical trial anatomical criteria, and central DMR patients undergoing M-TEER.

Methods: Drug-refractory moderate-to-severe DMR patients treated with M-TEER at Fuwai Hospital from January 2021 to February 2024 were retrospectively analyzed.

Genotype-by-Environment Effects of Cis-Variations in the Atgl Promoter Mediate the Divergent Pattern of Phenotypic Plasticity for Temperature Adaptation in Two Congeneric Oyster Species.

Phenotypic plasticity plays an essential role in adaptive evolution. However, the molecular mechanisms of how genotype-by-environment interaction (G × E) effects shape phenotypic plasticity in marine organisms remain poorly understood. The crucial temperature-responsive trait triacylglycerol (TAG) content and its major gene adipose triglyceride lipase (Atgl) expression have divergent plastic patterns in two congeneric oyster species (Crassostrea gigas and Crassostrea angulata) to adapt to relative-cold/northern and relative-warm/southern habitats, respectively.

Deciphering single-cell 3D chromatin structure using scCTG.

Sequencing-based Hi-C technology has been widely used to study the three-dimensional structure of chromatin. More recently, the development of single-cell Hi-C technology has enabled the study of chromatin structural variations between individual cells. However, single-cell Hi-C data are often highly sparse, necessitating the use of imputation algorithms to address insufficient sampling.

Quercetin alleviates metabolic-associated fatty liver disease by tuning hepatic lipid metabolism, oxidative stress and inflammation.

The natural flavonoid quercetin, which exhibits a range of biological activities, has been implicated in liver disease resistance in recent research. study attesting to quercetin's protective effect against metabolic-associated fatty liver disease (MAFLD) is inadequate, however. Here, our investigation explored the potential benefits of quercetin in preventing MAFLD in C57BL/6 mice fed a high-fat diet (HFD).

Reversible and irreversible retention of heavy metals in saturated porous media: association with kaolin.

Contamination of heavy metals (HMs) has caused increasing concern due to their ecological toxicities and difficulties in degradation. The transport, retention, and release of HMs in porous media are highly related to their environmental fate and risk to groundwater. Column transport experiments and numerical simulations were conducted to investigate the retention and release behaviors of Cu, Pb, Cd, and Zn in the presence and absence of kaolin under varying ionic strengths and cation types.

Thermodynamics and models for small nanoparticles upon protein adsorption.

Proteins are some of the most important components in living organisms. When nanoparticles enter a living system, they swiftly interact with proteins to produce the so-called "protein corona", which depicts the adsorption of proteins on large nanoparticles (normally tens to hundreds of nanometers). However, the sizes of small nanoparticles (typically, fluorescent nanomaterials such as quantum dots, noble metal nanoclusters, carbon dots, ) are less than 10 nm, which are comparable or even much smaller than those of proteins.

Phosphaguanidinate yttrium carbene, carbyne and carbide complexes: three distinct C1 functionalities.

The phosphaguanidinate rare-earth-metal bis(aminobenzyl) complexes [(PhP)C(NCHPr-2,6)]Ln(CHCH NMe-) (Ln = Y(1-Y) and Lu(1-Lu)) were synthesized by the protonolysis of (PhP)[C(NHR)(NR)] (R = 2,6-(Pr)CH) with Ln(CHCHNMe-) (Ln = Y and Lu). Interestingly, the ring-opening rearrangement product [-MeNCHCHC(NCHPr-2,6)]Lu(CHCHNMe-)[O(CH)PPh] (2) was obtained when the acid-base reaction was carried out in THF solution at 60 °C for 36 h. Additionally, the trinuclear homometallic yttrium multimethyl/methylidene complex {[(PhP)C(NCHPr-2,6)]Y(μ-Me)}(μ-Me)(μ-CH) (3) was synthesized by the treatment of 1-Y with AlMe (2 equiv.