Publications by authors named "Zhen-Jiang Yao"
Objective: Pulmonary tuberculosis (PTB) is a critical challenge worldwide, particularly in China. This study aimed to explore the spatiotemporal transmission patterns and socioeconomic factors of PTB in Dongguan city, China.
Methods/design: An ecological study based on the reported new PTB cases between 2011 and 2020 was conducted in Dongguan city, China.
[Screening of pathogenic molecular markers of in children based on whole genome sequencing technology].
Zhongguo Dang Dai Er Ke Za Zhi
November 2023
Objectives: To explore the molecular characteristics of () in children, and to compare the molecular characteristics of different types of strains (infection and colonization strains) so as to reveal pathogenic molecular markers of .
Methods: A cross-sectional study design was used to conduct nasopharyngeal swab sampling from healthy children in the community and clinical samples from infected children in the hospital. Whole genome sequencing was used to detect antibiotic resistance genes and virulence genes.
[Dose-response relationship between age and vaccination coverage in kindergarten children].
Zhongguo Dang Dai Er Ke Za Zhi
October 2023
Article Synopsis
- This study explores the connection between the age of kindergarten children and their vaccination coverage, highlighting its relevance for future vaccine development.
- Using a sample of 1,830 healthy children, researchers found that 22.46% carried certain bacteria, with significant non-linear relationships between age and the coverage of two vaccines, PCV10 and PCV13.
- The findings indicate that 2-year-old children had the highest vaccination rates, and the identified virulence genes suggest potential targets for new protein vaccines.
Objective: To evaluate the pharmacokinetics (PK), safety, and bioequivalence of two formulations of apixaban in healthy Chinese subjects under fasting and fed conditions.
Materials And Methods: A single-center, randomized, open, single-dose, two-period crossover PK study was carried out under fasting and fed conditions in 64 healthy subjects enrolled in either the fasting (36 subjects) or the fed (28 subjects) arms of the study. Subjects received a single oral dose of 2.
Co-carriage of and among preschool children and its influencing factors.
Zhongguo Dang Dai Er Ke Za Zhi
August 2022
Objectives: To investigate the carriage status of () and () in preschool children and the influencing factors for the carriage status.
Methods: The stratified cluster sampling method was used to select 2 031 healthy children from seven kindergartens in Shunde District of Foshan in Guangdong, China. Nasal swabs were collected from all children for the isolation and identification of and .
While previous studies have focused on the health effects of occupational exposure of radiations on medical radiation workers, few have analyzed the dose-response relationship between low radiation doses and changes in blood parameters. Even fewer studies have been conducted on industrial worker populations. Using a prospective cohort study design, this study collected health examination reports and personal dose monitoring data from 705 industrial irradiation workers who underwent regular physical examinations at Dongguan Sixth People's Hospital.
View Article and Find Full Text PDFAim: To examine the effect of pseudolaric acid B on the growth of human gastric cancer cell line, AGS, and its possible mechanism of action.
Methods: Growth inhibition by pseudolaric acid B was analyzed using MTT assay. Apoptotic cells were detected using Hoechst 33258 staining, and confirmed by DNA fragmentation analysis.