Publications by authors named "Zhen-Jia Cui"
Angew Chem Int Ed Engl
March 2024
Article Synopsis
- Sesquiterpene synthases (STPSs) are enzymes that create diverse hydrocarbons through carbocation-driven reactions, with deprotonation-reprotonation processes contributing significantly to this diversity.
- Research focused on two STPSs, AhCS and AhIS, showing they produce different compounds by selectively protonating at different positions of germacrene A (GA).
- Structural analyses and site-directed mutagenesis identified specific active site residues that control regioselectivity, allowing researchers to successfully interchange the functions of AhCS and AhIS, paving the way for designing STPSs with varied structural outputs.
