Publications by authors named "Zhen-Hua Tu"

Background: Infection is a significant risk factor that impacts for perioperative morbidity and mortality in liver transplantation (LTx) patients and is difficult to evaluate quantitatively in the early posttransplantation period. Thus, a biomarker to assess the risk of infection and the prognosis of the recipient is highly desirable.

Methods: A total of 128 consecutive patients with end-stage liver diseases undergoing LTx between January 1, 2020 and December 31, 2021, at the First Affiliated Hospital of Zhejiang University School of Medicine, were screened retrospectively.

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Purpose: To evaluate the response and safety of an inactivated vaccine (Sinovac Life Sciences Co., Ltd., Beijing, China) for coronavirus disease 2019 (COVID-19) in liver transplant (LTx) recipients from China.

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Background: Crigler-Najjar syndrome type I (CNS I) is a very rare autosomal recessive inherited disease that liver transplantation can properly deal with.

Methods: We present one case of an 18-month-old child with CNS I diagnosed by clinical findings and genetic detecting. LTx was performed 5 days after kernicterus broke out and neurological symptoms were successfully reversed.

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The detection of the quality of honey and the differentiation of adulteration are very important for quality and safety assurance. Traditionally used chemical methods were expensive and complicated, therefore they are not suitable for the requirement of wide-scale detection. In the past decade, the detection technology of honey developed with a trend of fast and high throughput detection.

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The potential of near infrared spectroscopy (NIR) as a nondestructive method for determining the principle components of honeys was studied for 153 unifloral honeys and multifloral honey samples. Fourier transform near-infrared spectroscopy (FT-NIR), CCD near-infrared spectroscopy and PDA near-infrared spectroscopy were evaluated to quantitatively determine water content, fructose content and glucose content in honey. On the basis of partial-least square (PLS) regression, the models of honey were compared.

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In the present study, 22 certified milk samples without melamine were collected, then 50 adulterated milk samples with added different content of melamine (0.1-1 500 mg x kg(-1)) were prepared. The near-infrared (NIR) spectra of these milk samples were measured.

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In the present study, the fruit flesh firmness of apple was analyzed by near infrared (NIR) spectroscopy using an FT-NIR spectrometer. The sensitive spectral regions that provide the lowest prediction error were analyzed by different well-known variable selection methods, including dynamic backward interval partial least-squares (dynamic biPLS), sequential application of backward interval partial least-squares and genetic algorithm(dynamic biPLS & GA-PLS), and iterative genetic algorithm partial least-squares (iterative GA-PLS). Iterative GA-PLS, dynamic biPLS & GA-PLS led to a distinct reduction in the number of spectral data points with better predictive quality.

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In the present work, "Fuji" apples from Shandong Yantai were used to take the diffuse reflection spectra by FT-NIR PLS components (i.e., factors) were computed by nonlinear iterative partial least squares (NIPALS) and the number of latent factors (LV) was optimized by a leave-one-out cross-validation procedure on the calibration set.

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In the present study, improved laser-induced light backscattering imaging was studied regarding its potential for analyzing apple SSC and fruit flesh firmness. Images of the diffuse reflection of light on the fruit surface were obtained from Fuji apples using laser diodes emitting at five wavelength bands (680, 780, 880, 940 and 980 nm). Image processing algorithms were tested to correct for dissimilar equator and shape of fruit, and partial least squares (PLS) regression analysis was applied to calibrate on the fruit quality parameter.

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Objective: To study the related proteins of apoptosis initiation induced by homoharringtonine (HHT) in HL-60 cells.

Methods: After establishment of an apoptosis initiation model induced by HHT in HL-60 cells, proteins of untreated and HHT treated HL-60 cells were extracted, and the two-dimensional polyacrylamide gel electrophoresis (2-DE) maps of the extracted proteins were established by using the immobilized pH gradient (IPG) two-dimensional electrophoresis respectively. The alteration protein spots were identified with assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) and database searching.

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Objective: To investigate the efficacy of the specific murine anti-human CD(3) T lymphocyte monoclonal antibody (CD(3) MoAb) for severe aplastic anemia (SAA).

Methods: 13 SAA patients were chosen with a medium age of 22 years, including 4 untreated patients and 9 nonresponding to previous management. They were treated with 5 mg of CD(3) MoAb per day for a total 10 days.

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