A pilot study: effect of erythrocyte lifespan determined by a modified carbon monoxide breath test on glycosylated hemoglobin interpretation.

Glycosylated hemoglobin (HbA1c) is an important criterion for the diagnosis of diabetes and an indicator of the blood glucose level. The red blood cell (RBC) lifespan heterogeneity is sufficient to influence the HbA1c interpretation. In this study, we recruited 120 patients with diabetes mellitus and 85 nondiabetic controls.

[The effect of smoking on resting energy expenditure in patients with early diabetic kidney disease].

Objective: To study the effect of smoking on resting energy expenditure (REE) and the relationships among REE, smoking, inflammation and oxidative stress in patients with diabetic kidney disease.

Methods: A case control study of 31 smokers and 40 non-smokers with early stage of diabetic kidney disease (stage III) were performed to evaluate the chronic effect of smoking on REE. REE/fat free mass (FFM), biomarkers of oxidative stress malondialdehyde (MDA), superoxide dismutase (SOD) and inflammation high-sensitivity C-reactive protein (hs-CRP), adiponectin, TNFα were also measured in these subjects.