Publications by authors named "Zhen-Guo Wang"

Objective: To explore the potential mechanism of lysionotin in treating glioma.

Methods: First, target prediction based on Bernoulli Naïve Bayes profiling and pathway enrichment was used to predict the biological activity of lysionotin. The binding between 5-lipoxygenase (5-LO) and lysionotin was detected by surface plasmon resonance (SPR) and molecular docking, and the inhibitory effects of lysionotin on 5-LO and proliferation of glioma were determined using enzyme inhibition assay in vitro and cell viability analysis, respectively.

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  • Fucoidan and deep-sea water (DSW) show potential benefits for treating type 2 diabetes (T2DM) when combined, as tested on rats with high fat diet-induced T2DM.
  • The combination, especially at a high dose (H-CDF), effectively reduced weight loss, lowered fasting blood glucose and lipid levels, and improved liver and pancreas health compared to either treatment alone.
  • H-CDF also positively influenced gut microbiota diversity and metabolism, particularly affecting bile acid and linoleic acid pathways, which enhances insulin sensitivity and metabolic health.
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Bunge (Lamiaceae) is a perennial herb widely found in China since ancient times with a high economic and medicinal value. Salvianolic acid B (Sal-B) is an important natural product derived from and this review summarizes the anticancer activity of Sal-B. Sal-B inhibits tumor growth and metastasis by targeting multiple cell signaling pathways.

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Glyceroglycolipids are major metabolites of marine algae and have a wide range of applications in medicine, cosmetics, and chemistry research fields. They are located on the cell surface membranes. Together with glycoproteins and glycosaminoglycans, known as the glycocalyx, they play critical roles in multiple cellular functions and signal transduction and have several biological properties such as anti-oxidant and anti-inflammatory properties, anti-viral activity, and anti-tumor immunity.

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  • Sorghum is a crucial crop for food security in dry regions due to its resilience to challenges like poor soil and pests, making it suitable for low-fertility lands.
  • A two-year study in China explored how different factors—like variety, location, sowing dates, and plant density—affect sorghum yields, revealing that location had the largest impact, followed by variety, while factors like sowing date and density contributed less.
  • The research concluded that mid-maturing sorghum varieties are preferable in spring sowing early maturing areas, as they perform better under varying climate conditions during critical growth stages.
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  • Deep sea water (DSW) is a natural resource with high levels of minerals that can help combat diabetes and might protect against cognitive decline related to Alzheimer's disease (AD).
  • In experiments with type 2 diabetes rats, DSW improved learning and memory while increasing beneficial mineral concentrations in the brain.
  • The study suggests that DSW works by activating a specific genetic signaling pathway (PI3K/Akt/GSK-3β), which helps reduce harmful Tau protein levels linked to AD, indicating its potential use as a natural treatment for neuroprotection.
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Traditional Chinese medicines (TCMs) have wide pharmacological activities, and the ingredients in individual TCMs determine their efficacies. To understand the "efficacy-nature-structure" relationship of TCM, compounds from 2444 kinds of herbs were collected, and the associations between family, structure, nature, and biological activities were mined and analyzed. Bernoulli Naïve Bayes profiling and a data analysis method were used to predict the targets of compounds.

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Objective: To assess the effect and safety of bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance.

Methods: In this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the bloodletting group received additional bloodletting puncture at HTWPs on admission immediately before conventional treatment.

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Ethnopharmacological Relevance: Traditional Chinese Medicine (TCM) has been widely used as an approach worldwide. Chinese Medicines (CMs) had been used to treat and prevent viral infection pneumonia diseases for thousands of years and had accumulated a large number of clinical experiences and effective prescriptions.

Aim Of The Study: This research aimed to systematically excavate the classical prescriptions of Chinese Medicine (CM), which have been used to prevent and treat Pestilence (Wenbing, Wenyi, Shiyi or Yibing) for long history in China, to obtain the potential prescriptions and ingredients to alternatively treat COVID-19.

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Objective: To study the effect of exendin-4(Ex-4) on the differentiation of neural stem cells(NSCs) in adult mouse subventricular zone(SVZ)and its mechanism .

Methods: NSCs in the SVZ were derived from 5-week C57BL/6J mice and the expression of nestin was detected by immunofluorescence. The cell morphology was observed after the cells treatmed with 100 nmol/L Ex-4 for 14 days.

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Spinal cord injury (SCI) is a disaster that can cause severe motor, sensory, and functional disorders. Implanting biomaterials have been regarded as hopeful strategies to restore neurological function. However, no optimized scaffold has been available.

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Calcium overload is a vital mechanism of myocardial ischemia-reperfusion injury, which is a hot therapeutic target in cardiovascular research. It has been well recognized that the dysfunction of calcium relevant proteins, including L-type voltage- dependent calcium channel (L-VDCC), sarco/endoplasmic reticulum ATPase 2a (SERCA2a)/phospholamban (PLB), RyR2, Na/Ca exchanger, Na/H exchanger, etc. contributes to calcium overload in cardiomyocytes during ischemia-reperfusion injury, in which the diastolic calcium concentration is increased and the amplitude of calcium transients is decreased.

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Objective: To conduct a meta-analysis of available comparative studies evaluating hybrid arch repair versus open surgical repair of aortic arch aneurysm.

Methods: A literature search was performed using PubMed, Embase and Web of Science to identify any studies comparing the results of hybrid arch repair with open surgical repair of aortic arch aneurysm. Study quality was assessed with the Newcastle-Ottawa Scale.

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The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization.

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Objective: Vascular endothelial (VE)-cadherin is the predominant component of endothelial adherens junctions essential for cell-cell adhesion and formation of the vascular barrier. Endocytic recycling is an important mechanism for maintaining the expression of cell surface membrane proteins. However, little is known about the molecular mechanism of VE-cadherin recycling and its role in maintenance of vascular integrity.

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Objective: To evaluate the bio-safety of graphene quantum dots (GQDs), we studied its effects on the embryonic development of zebrafish.

Methods: In vivo, biodistribution and the developmental toxicity of GQDs were investigated in embryonic zebrafish at exposure concentrations ranging from 12.5-200 μg/mL for 4-96 h post-fertilization (hpf).

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Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury.

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Objective: To study the mechanism of warm-hot nature Chinese drugs (WHNCD) for promoting blood circulation and removing blood stasis (PBCRBS) for intervening model rats of cold coagulation and blood stasis syndrome (CCBSS).

Methods: CCBSS rat model was set up in outbred SD rats using ice water immersion method. Totally 300 successfully modeled CCBSS rats were randomly divided into 5 groups according to the principle of balance weight, 60 in each group.

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By using the Fourier transform infrared spectroscopy and linear discriminant analysis (LDA), logistic discriminant analysis (Logistic-DA), principal component analysis-linear discriminant analysis (PCA-LDA), partial least-squares discriminant analysis (PLS-DA), random forest (RF), support vector machine (SVM), infrared spectra of 60 kinds of plant extract of Chinese traditional medicine were analyzed and the identification and evaluation of characteristics of the regional markers associated with cold and heat nature were studied. Results indicated that LDA and SVM are suitable for the recognition model of water extract infrared spectral data, LDA is suitable for the identification model of anhydrous ethanol extract infrared spectral data, SVM is suitable for the identification model of chloroform extract infrared spectral data, while petroleum ether extract group recognition effect is not ideal. According to the suitable characteristic parameters identification model, data were analyzed by infrared spectroscopy, and parameters and resistance characteristics of the traditional Chinese drug composition can be obtained.

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Objective: To establish signature pattern recognition model of cold-hot nature of herbal medicine.

Methods: High performance capillary electrophoresis fingerprints of 60 kinds of herbal medicine (30 kinds of cold, 30 of hot) were established, features of wavelength were screened, 6 analysis methods such as linear discriminant analysis (LDA), logistic discriminant analysis (Logistic-DA), principal component and linear discriminant analysis (PCA-LDA), partial least-squares discriminant analysis (PLS-DA), random forest (RF) and support vector machine (SVM) were used to establish and evaluate recognition model of cold-hot nature after data processing.

Results: SVM was proved to be a suitable means of recognition model of herbal medicine cold-hot nature based on data of HPCE fingerprints.

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Activation of TLR4 by the endotoxin LPS is a critical event in the pathogenesis of Gram-negative sepsis. Caveolin-1, the signaling protein associated with caveolae, is implicated in regulating the lung inflammatory response to LPS; however, the mechanism is not understood. In this study, we investigated the role of caveolin-1 in regulating TLR4 signaling in endothelial cells.

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The "jin yin hua" (Lonicera japonica Thunb.) used in the clinic nowadays is the flower of honeysuckle, excluding its stem, leave, branch, vine or the whole plant. In the early time, the name of "ren dong" (honeysuckle) or "ren dong teng" (Caulis lonicerae) didn't refer exclusively to the flower of honeysuckle.

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Objective: To explore appropriate methods for the research of the theory of Chinese medicine nature property and find the relationship between Nature-Family-Component of Chinese herbs.

Methods: From perspective of systems biology, we used Associate Network to identify useful relationships among "Nature-Family-Component" of Herbs. In this work, Associate Network combines association rules mining method and network construction method to evaluate the complicate relationship among "Nature-Family-Component" of herbs screened.

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The evolutionary relationship and functional correlation between human formyl peptide receptors (FPRs) and their mouse counterparts remain incompletely understood. We examined three members of the mouse formyl peptide receptor subfamily (mFprs) and found that they differ in agonist preference and cellular distributions. When stably expressed in transfected rat basophilic leukemia (RBL-2H3) cells, mFpr1 was readily activated by N-formylated peptides derived from Listeria monocytogenes (fMIVTLF), Staphylococcus aureus (fMIFL), and mitochondria (fMMYALF).

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There are significant differences of the XIAO-named herb between Shennong's Herbal Classic and the Song-edition Treatise on Febrile Disease and Synopsis of the Golden Chamber. The reasons are: (1) With the development of history, differentiation of herb category and effect kept changing from the Han Dynasty to the Song Dynasty, which led to the differences in concept and entity of herbs in different periods. (2) Lin Yi of the Song Dynasty may have redefined some herb's names according to the current situation when he revised Zhang Zhongjing's works.

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