FOXK1 promotes cell growth through activating wnt/β-catenin pathway and emerges as a novel target of miR-137 in glioma.

Glioma is the most common primary malignant brain tumor in adults. Forkhead box k1 (FOXK1) was reported to be dysregulated and play important roles in multiple human cancers. However, the expression pattern and roles of FOXK1 in glioma has never been investigated.

Statistics of extremes in oil spill risk analysis.

The Deepwater Horizon oil spill (DWH) in 2010 in the Gulf of Mexico is the largest accidental marine oil spill in the history of the petroleum industry. After DWH, key questions were asked: What is the likelihood that a similar catastrophic oil spill (with a volume over 1 million barrels) will happen again? Is DWH an extreme event or will it happen frequently in the future? The extreme value theory (EVT) has been widely used in studying rare events, including damage from hurricanes, stock market crashes, insurance claims, flooding, and earthquakes. In this paper, the EVT is applied to analyze oil spills in the U.

Three dimensional water quality modeling of a shallow subtropical estuary.

Knowledge of estuarine hydrodynamics and water quality comes mostly from studies of large estuarine systems. The processes affecting algae, nutrients, and dissolved oxygen (DO) in small and shallow subtropical estuaries are relatively less studied. This paper documents the development, calibration, and verification of a three dimensional (3D) water quality model for the St.

Gene expression profiles of human osteosarcoma cell sublines with different pulmonary metastatic potentials.

Aim: to screen the pulmonary metastasis-associated molecules of Osteosarcoma and evaluate their functions concerning prognosis prediction.

Methods: cDNA microarray analysis has been applied to 2 pairs of osteosarcoma cell sublines with differential metastatic potentials to the lung. Immunohistochemistry and survival analysis have been performed to clinical samples of osteosarcoma patients.

Use of physical sciences in support of environmental management.

Offshore drilling for oil and gas has been conducted since the early 1900s. Oil and gas under the seabed continue to be an important part of the energy resources of the United States. The need to balance the value of these resources against the potential for environmental damage is an important concern.