Two new lactam derivatives from a derived fungus PQJ-2.

A new bicyclic lactam derivatives penicilactam B () and a new monocyclic amide penicillamide D (), along with four known compounds (), were isolated from the fermentation broth of the derived fungus PQJ-2. Their structures and stereochemistry were elucidated by comprehensive spectroscopic analyses and quantum ECD calculations. All the compounds were evaluated for their antibacterial activities against subsp and insecticidal activity against Hubner.

[The characterization on the site of vindoline binding to human serum albumin].

In this paper, the fluorogenic property of vindoline was exploited and, as a probe, used to analyze the interaction of vindoline with HSA by fluorescence and absorption spectra in combination with molecular modeling under a simulated physiological conditions. The evidences from synchronous fluorescence and absorption spectroscopes showed the effect of vindoline on the microenvironment around HSA in aqueous solution. Data obtained by the fluorescence spectroscopy indicated that binding of vindoline with HSA leads to dramatic enhancement of the fluorescence emission intensity.