Publications by authors named "Zhen Qi"

The excessive release of reactive oxygen species (ROS) after myocardial infarction (MI) disrupts the natural healing process, leading to cardiac fibrosis and compromising patient prognosis. However, the clinical application of many antioxidant drugs for MI treatment is hindered by their poor antioxidant efficacy and inability to specifically target the heart. Here we developed a tannic acid-modified MnO nanozyme (named MnO@TA), which can achieve cardiac targeting to inhibit post-MI fibrosis and enhance cardiac function.

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Aortic dissection (AD) poses a significant threat to cardiovascular health globally, yet its underlying mechanisms remain elusive. Smooth muscle cells death and phenotypic switching are critically important pathological processes in AD. Currently, no pharmacological therapies have proven effective in managing AD.

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  • The study aimed to assess the puncture accuracy of four conventional frontal ventriculostomy methods, using patient data from CT scans to create a 3D model for simulation.
  • Data from 206 patients showed varying levels of puncture accuracy: IMC (13.3%), MAM (74.5%), P (90.5%), and CMC (100%) with corresponding puncture depths.
  • Results indicate that CMC and P trajectories are more reliable than MAM for puncture accuracy, while the IMC trajectory is only advisable for wider frontal horns.
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  • Supramolecular coordination assemblies are crucial in material science and biology, but most current examples lack adaptability due to being thermodynamically controlled.
  • This research introduces non-equilibrium coordination assembly systems that evolve over time, transitioning from metastable fiber structures to stable nanosheets with the help of zinc ions.
  • The evolution process can be tracked using multicolor fluorescence and can be influenced by external factors, showcasing a versatile approach applicable with other ions like Ca, Mg, and Al.
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Background: Darier's disease (DD) is a skin disorder caused by mutations in the ATP2A2 gene. Researchers have been investigating the correlation between genotype and phenotype in DD. Understanding the genotype-phenotype relationship in DD can enhance our comprehension of the genetic background and phenotypic characteristics of the condition, as well as the relationship between its systemic and localized manifestations.

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Fibrous tarpaulin serves as the core barrier that protects goods, people, or areas from the adverse impacts of the external environment, such as rain, dust, and sunlight. However, conventional tarpaulins exhibit inadequate mechanical properties, a low solar reflectance, and are susceptible to pollution. To address these issues, a bioinspired polylactic acid/polyethylene glycol @silicon dioxide (PLA/PEG@SiO₂) microfibrous tarpaulin with a dual-layer heterogeneous structure was fabricated via in-situ drafting melt-blowing combined with thermal bonding, inspired by the layered structure of shells.

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  • Psoriasis, an autoimmune disease, shows variations influenced by season and geography, highlighting the importance of studying double-stranded DNA (dsDNA) levels in relation to climate.
  • A study from 2016 to 2020 analyzed 10,110 psoriasis patients across different regions in China, focusing on how serum dsDNA levels differed by season and latitude.
  • Results indicated higher serum dsDNA levels in Northern and medium-latitude regions, during winter compared to summer, and emphasized the impact of factors like UV exposure, humidity, and age on dsDNA concentrations.
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Direct current (DC) has promising potential for persulfate delivery and activation in heterogeneous site remediation, yet requires deeper understanding. Here, we investigated the efficiency of DC for persulfate delivery and activation and compared with alternating current (AC). While AC electric field only influenced persulfate fate by Joule heating effect, DC electric field induced electrokinetic migration of persulfate and contaminants, as well as promoted persulfate activation with Joule heating and electrochemical reactions.

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A non-equilibrium cucurbit[7]uril-mediated supramolecular host-guest system is fabricated by using urea/urease to control aqueous solution pH on time dimension, showing transient assembly behavior and time-dependent fluorescence. The dynamic assembly can be also achieved in hydrogel network, resulting in a time-dependent fluorescent hydrogel for information encryption.

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In the face of escalating global temperatures, the demand for innovative passive cooling technologies that are both low-cost and environmentally sustainable is more critical than ever. However, traditional cooling fabrics face challenges in achieving wearing comfort while maintaining breathability and durability. Herein, a novel fluffy microfibrous fabric utilizing polyolefin-elastomer and polypropylene with embedded zinc oxide nanoparticles is fabricated through melt-blown technology.

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The work numerically investigated laminar natural convection heat transfer from the single sphere with a constant heat flux surface in air over the wide range of Grashof number ( ). The more efficient and precise numerical method based on Bejan et al. was employed here, the accuracy of which has been confirmed through validation against a single sphere case.

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Electrochemical CO reduction is a promising technology for replacing fossil fuel feedstocks in the chemical industry but further improvements in catalyst selectivity need to be made. So far, only copper-based catalysts have shown efficient conversion of CO into the desired multi-carbon (C) products. This work explores Cu-based dilute alloys to systematically tune the energy landscape of CO electrolysis toward C products.

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Background: CaIMR is proposed as a novel angiographic index designed to assess microcirculation without the need for pressure wires or hyperemic agents. We aimed to investigate the impact of caIMR on predicting clinical outcomes in STEMI patients.

Methods: One hundred and forty patients with STEMI who received PCI in Putuo Hospital of Shanghai from October 2021 to September 2022 were categorized into CMD and non-CMD groups according to the caIMR value.

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  • Freckles are a common skin condition that has a hereditary link, with previous research identifying many genetic risk factors through studies on other diseases.
  • A new study conducted a Genome-Wide Association Study (GWAS) and meta-analysis on 4,813 Chinese individuals, revealing new genetic variants linked to freckles.
  • The research identified 59 new single nucleotide polymorphisms (SNPs) and 13 novel genes that may increase susceptibility to freckles, contributing significantly to the understanding of their genetic basis.
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A BEM (boundary element method) based approach is developed to accurately solve an EEG/MEG forward problem for a modern high-resolution head model in approximately 60 seconds using a common workstation. The method utilizes a charge-based BEM with fast multipole acceleration (BEM-FMM) and a "smart" mesh pre-refinement (called -refinement) close to the singular source(s). No costly matrix-filling or direct solution steps typical for the standard BEM are required; the method generates on-skin voltages as well as MEG magnetic fields for high-resolution head models in approximately 60 seconds after initial model assembly.

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DFT and TD-DFT were used in this article to investigate the effects of different substitutions at multiple sites on the photophysical mechanism of bis-HBX in the gas phase. Four different substitution modes were selected, denoted as A (X=Me, Y=S), A (X=OMe, Y=S), B (X=Me, Y=NH), and C (X=Me, Y=O). The geometric parameters proved that the IHBs enhanced after photoexcitation, which was conducive to promote the ESIPT process.

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Coastal wetlands are the main distribution of blue carbon in coastal zones and well known for their high carbon sequestration capacity. Investigating the variation of carbon budget is crucial for understanding the functionality of coastal wetlands and effectively addressing climate change. In this study, a bibliometric analysis of 4,509 articles was conducted to reveal research progress, hot issues, and emerging trends in the coastal wetland carbon budget field.

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The water source reservoirs are the important urban water source in northern China. Although external pollution has been greatly improved, the internal pollutants in reservoirs continue to accumulate with the complex deposition and release processes, resulting in potential risks to water supply safety. To address the aforementioned issue, this paper proposed a simulation model of water quality named ECOlab EU1-WSR to simulate the spatio-temporal changes of water quality under the influence of internal pollution for the water source reservoirs.

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Disuse muscle atrophy (DMA) is a significant healthcare challenge characterized by progressive loss of muscle mass and function resulting from prolonged inactivity. The development of effective strategies for muscle recovery is essential. In this study, we established a DMA mouse model through hindlimb suspension to evaluate the therapeutic potential of lactate in alleviating the detrimental effects on the gastrocnemius muscle.

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Circularly polarized luminescence (CPL) is promising for applications in many fields. However, most systems involving CPL are within the visible range; near-infrared (NIR) CPL-active materials, especially those that exhibit high g values and can be controlled spatially and temporally, are rare. Herein, dynamic NIR-CPL with a g value of 2.

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Direct current (DC) electric field has shown promising performance in contaminated site remediation, in which the Joule heating effect plays an important role but has been previously underappreciated. This study focuses on the spatiotemporal characteristics and mechanism of temperature change in heterogeneous porous media with applied DC. The heating process can be divided into four phases: preferential heating of the low permeability zone (LPZ), rapid heating in the middle region, temperature drop and hot zone shift, and reheating.

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  • Lactate functions as both an energy source and a signaling molecule, positively affecting skeletal muscle physiology and potentially serving as a sports supplement, though its mechanisms remain unclear.
  • Administration of lactate improved antifatigue ability and altered the expression of myosin heavy chain proteins, indicating a shift in muscle fiber types, while also changing the metabolic profile of the muscle.
  • The study found that lactate enhances metabolic enzyme activities and promotes the transport of lactate, while activating a signaling pathway involving calcium and NFATC1 that influences muscle adaptation and myofiber-type transitions.
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Unlabelled: Modeling brain stimulation at the microscopic scale may reveal new paradigms for various stimulation modalities. We present the largest map to date of extracellular electric field distributions within a layer L2/L3 mouse primary visual cortex brain sample. This was enabled by the automated analysis of serial section electron microscopy images with improved handling of image defects, covering a volume of 250 × 140 × 90 μm .

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Cutaneous sympathetic nerve is a crucial part of neuropsychiatric factors contributing to skin immune response, but its role in the psoriasis pathogenesis remains unclear. It is found that cutaneous calcium/calmodulin-dependent protein kinase II-γ (CAMK2γ), expressed mainly in sympathetic nerves, is activated by stress and imiquimod in mouse skin. Camk2g-deficient mice exhibits attenuated imiquimod-induced psoriasis-like manifestations and skin inflammation.

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