Publications by authors named "Zhen Pan"

Compressed ultrafast photography (CUP) has attracted significant attention in the field of ultrafast optical imaging but is inherently constrained by a trade-off between sequence depth and spatial resolution. To address this limitation, we present a novel, to the best of our knowledge, system called spatial line integral CUP (LI-CUP). LI-CUP utilizes a cylindrical lens to compress each encoded time-slice frame into a spatial line, which is then recorded by a streak camera with a narrow slit.

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No studies have examined the prognostic value of the log odds of negative lymph nodes/T stage (LONT) in locally advanced rectal cancer (LARC) treated with neoadjuvant chemoradiotherapy (nCRT). We aimed to assess the prognostic value of LONT and develop a machine learning model to predict overall survival (OS) and disease-free survival (DFS) in LARC patients treated with nCRT. The study included 820 LARC patients who received nCRT between September 2010 and October 2017.

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Four yeast strains belonging to the ascomycetous yeast genus were isolated from the mixture of remnants of steamed sorghum, Daqu powder and the fermented grain that fell off during transportation on the ground in the workshop which were collected in Xinghuacun Fenjiu old workshop, Shanxi province, PR China. We propose the name sp. nov.

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The development of Ag-free Sn solders has attracted significant attention due to the requirement of high-density electronic packaging. In this study, we investigate the Ni element on the microstructures and mechanical properties of Ag-free Sn-Cu-Bi-In solders. This paper details the microstructures and phases of the as-prepared Sn-Cu-Bi-In-Ni solders, as well as its mechanical properties.

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Objective: Type 2 diabetes mellitus (T2DM) is a serious, chronic metabolic disease globally and its pathogenesis is not completely understood yet. This study aimed to thoroughly investigate the fluctuation of inflammatory markers in the peripheral blood of patients with T2DM, which are rarely reported.

Methods: Peripheral blood samples from patients with T2DM and healthy individuals, as well as their clinical information, were collected at the Second Affiliated Hospital of Soochow University.

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The absence of an effective imaging tool for diagnosing renal ischemia-reperfusion injury (RIRI) severely delays its treatment, and currently, no definitive clinical interventions are available. Pyroglutamate aminopeptidase-1 (PGP-1), a potential inflammatory cytokine, has shown considerable potential as a biomarker for tracing the inflammatory process in vivo. However, its exact role in the enhanced visualization of RIRI in complex biological systems has yet to be fully established.

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The effect of carbon fibers (Cf) and Ni nanoparticles addition on the melting point, microstructure, shear strength, indentation hardness and indentation creep of SnBi/Cu solder joints were explored. Composite solder with various Cf percentages (0, 0.02, 0.

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The fermentation process of Chinese baijiu, a distinctive example of batch solid-state fermentation (BSSF), involves the recurrent use of the same raw material to optimize starch utilization. However, it is unclear which microorganisms are able to metabolize low concentration starch effectively. In this study, we successfully identified the key saccharifying microbiota that degraded low-concentration starch in the BSSF system by absolute quantification techniques.

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Short-chain fatty acid ethyl esters (SFAEEs) are critical aroma compounds in Baijiu, and their wider concentration range can lead to differences in the quality grade of Baijiu. Efficiently designing an SFAEEs adsorbent before instrument analysis remains challenging. In this work, nine functionalized covalent organic frameworks (COFs) with different postmodification groups were designed for targeting SFAEEs.

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It is crucial for the successful transplantation of large segmental bone defects to achieve rapid vascularization within bone scaffolds. However, there are certain limitations including uncontrolled angiogenesis and inadequate vascular function. Therefore, there is an urgent need to develop bone scaffolds with functional vascular networks.

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Background: The prognostic value of Albumin and D-dimer has been established for multiple tumor types, indicating their potential for predicting tumor development. Nevertheless, the predictive capability of the DDI-to-albumin ratio (DAR) in locally advanced rectal cancer (LARC) remains uncertain.

Purpose: The objective of this study was to investigate the prognostic significance of the DAR in LARC.

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Article Synopsis
  • Developing chemiluminescent (CL) probes that can effectively differentiate between liver tumors and healthy tissue is essential for better visualization during surgery.
  • A new CL probe, CYP-PD, was created to specifically target the enzyme CYP 2J2, which is found in high levels in liver tumors but not in healthy tissues.
  • CYP-PD showed impressive sensitivity, detecting as low as 1.21 pM of the enzyme and providing a high tumor-to-normal tissue ratio, making it a promising tool for liver cancer detection and image-guided surgery.
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In clinical practice, timely and accurate diagnosis can effectively reduce unnecessary treatment, avoid high medical costs, and prevent adverse prognoses. However, some patients with malignant tumors and those with infection often exhibit similar symptoms, which are difficult to distinguish, posing challenges in accurate clinical diagnosis. Metagenomic next-generation sequencing (mNGS) technology has been widely applied to confirm the source of infection.

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Cancellous bone plays a critical role as a shock absorber in the human skeletal system. Accurate assessment of its microstructure and mechanical properties is crucial for osteoporosis diagnosis and treatment. However, various methods with different indicators are adopted currently in the clinical and laboratory assessments which lead to confusion and inconvenience for cancellous bone analysis.

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In this paper, a fiber optic sensor with draw-tower-grating (DTG)-based Fabry-Perot interferometers (FPIs) are proposed to measure the temperature and salinity of seawater simultaneously. The sensing structure utilizes DTG as the reflector, and two adjacent gratings can be cascaded to compose an FPI. By employing moisture-sensitive materials to the surface of the optical fiber, the variation in salinity can be measured by the axial strain applied by the coating on the sensing optical fiber.

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The butyric acid biorefinery technology for straw is highly significant for environmental protection and the restructuring of the energy system. However, this process produces waste from alkali-heat pretreatment (PW) and butyric acid fermentation (FW). In this study, the feasibility of methane fermentation from the wastes was confirmed, with the methane production from PW and FW of 351.

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Article Synopsis
  • This study focuses on the importance of accurately predicting pathological complete response (pCR) in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiotherapy, highlighting limitations in existing predictive models that mainly consider pre-treatment factors.
  • The researchers developed a new predictor using dynamic changes in systemic inflammation-nutritional marker indexes (SINI) throughout the treatment process and created machine-learning models to enhance prediction accuracy.
  • By analyzing data from two patient cohorts and applying advanced statistical methods, including logistic regression and machine learning, the study aims to improve the identification of independent risk factors for pCR and enhance treatment strategies for patients.
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  • The study investigates the impact of tumor location in ultra-low rectal cancer on patient survival and how total hiatal ligament excision (THLE) affects outcomes for those with posterior rectal cancer.
  • Results show that circumferential tumor location (CTL) does not influence overall survival or disease-free survival, but THLE significantly reduces local recurrence compared to traditional transection.
  • Key risk factors for local recurrence-free survival include circumferential resection margin (CRM), TNM stage III, and traditional hiatal ligament transection (HLTT).
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Inflammation is a major impediment to the healing of cartilage injuries, yet bioactive scaffolds suitable for cartilage repair in inflammatory environments are extremely rare. Herein, we utilized electrospinning to fabricate a two-dimensional nanofiber scaffold (2DS), which was then subjected to gas foaming to obtain a three-dimensional scaffold (3DS). 3DS was modified with metal phenolic networks (MPNs) composed of epigallocatechin gallate (EGCG) and strontium ions (Sr) to afford a MPNs-modified 3D scaffold (3DS-E).

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  • Chinese Baijiu is a well-known alcoholic drink from China, and this study focuses on the interactions between key microorganisms during its fermentation at different temperatures.
  • Results showed that one microorganism significantly reduced the growth and lactic acid production of another when the temperature was above 15 °C, while the first microorganism did not affect the growth of a third microorganism involved in ethanol production.
  • A detailed analysis revealed that key enzymes for sugar metabolism and lactic acid production were less active in the presence of the dominant microorganism, highlighting its inhibitory role and offering insights for optimizing Baijiu fermentation processes.
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  • Osteosarcoma, the most common malignant bone tumor in kids and teens, has inadequate treatment options due to toxicity and resistance, highlighting the need for better therapies.
  • This study evaluated the effectiveness of avermectin B1, a new drug, against osteosarcoma cells, measuring its impact on cell growth, cell cycle, apoptosis, and the AMPK/ULK1 signaling pathway.
  • Results showed that avermectin B1 reduces cell proliferation, migration, and invasion, and promotes apoptosis and autophagy, making it a promising treatment option for osteosarcoma via the AMPK/ULK1 pathway.
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Impaired callus remodeling significantly contributes to the delayed healing of osteoporotic fractures; however, the underlying mechanisms remain unclear. Sensory neuronal signaling plays a crucial role in bone repair. In this study, we aimed to investigate the pathological mechanisms hindering bone remodeling in osteoporotic fractures, particularly focusing on the role of sensory neuronal signaling.

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Compressed ultrafast photography (CUP) can capture irreversible or difficult-to-repeat dynamic scenes at the imaging speed of more than one billion frames per second, which is obtained by compressive sensing-based image reconstruction from a compressed 2D image through the discretization of detector pixels. However, an excessively high data compression ratio in CUP severely degrades the image reconstruction quality, thereby restricting its ability to observe ultrafast dynamic scenes with complex spatial structures. To address this issue, a discrete illumination-based CUP (DI-CUP) with high fidelity is reported.

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Article Synopsis
  • * The study investigates mometasone furoate (MF), a glucocorticoid with potential antitumor effects, which was found to inhibit osteosarcoma cell growth and spread in a dose-dependent manner without harming internal organs.
  • * MF activates the AMPK/mTOR pathway to induce cell cycle arrest and apoptosis in osteosarcoma cells, suggesting it could be a valuable focus for future cancer treatment research.
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