Single Rare-Earth Ion Doped Tin-Oxo Nanocluster Photoresists for High-Resolution Extreme Ultraviolet Lithography.

Rare-earth (RE) metals are known as industrial vitamins and show significant regulatory effects in many fields. In this work, we first demonstrated that the vitamin effect of RE metals can also be applied to extreme ultraviolet (EUV) lithography. Using a SnRE oxo cluster as the universal platform, different individual RE metal ions were successfully doped to obtain a series of isomorphic heterometallic clusters (RE = Y, Sm, Eu, Ho, Er).

HKA angle exceeding 5 degrees is strongly associated with lateral patellar translation beyond 2 mm: surgical recommendations for avoiding adverse effects on the patellofemoral joint after OWHTO.

Purpose: Previous studies reported that anterior knee pain (AKP) occurs with an incidence of 32% after opening-wedge high tibial osteotomy (OWHTO). However, the biomechanical effects of this procedure on patellofemoral joints (PFJs) remain unclear. We aimed to quantify the changes in the kinematics and cartilage conditions of the PFJ during stair climbing before and after OWHTO.

The application of rigid gas permeable contact lenses after surgery for infantile nystagmus syndrome.

The purpose of this study is to investigate the improvement in visual acuity when applying Rigid Gas Permeable Contact Lenses (RGPCL) compared to spectacles in patients after surgical treatment for infantile nystagmus syndrome (INS). A total of 33 patients with nystagmus who had nystagmus surgery from October 2020 to July 2021 were enrolled and all were fitted RGPCL. SPSS statistical software was used to analyze the difference between best-corrected visual acuity with spectacle(BCSVA) and best-corrected visual acuity with RGPCL (BCRVA) in these patients.

Video laryngoscopy may improve the intubation outcomes in critically ill patients: a systematic review and meta-analysis of randomised controlled trials.

Background: The role of video laryngoscopy in critically ill patients requiring emergency tracheal intubation remains controversial. This systematic review and meta-analysis aimed to evaluate whether video laryngoscopy could improve the clinical outcomes of emergency tracheal intubation.

Methods: We searched the PubMed, Embase, Scopus and Cochrane databases up to 5 September 2024.

Heterogeneity of immune cells and their communications unveiled by transcriptome profiling in acute inflammatory lung injury.

Background: Acute Respiratory Distress Syndrome (ARDS) or its earlier stage Acute lung injury (ALI), is a worldwide health concern that jeopardizes human well-being. Currently, the treatment strategies to mitigate the incidence and mortality of ARDS are severely restricted. This limitation can be attributed, at least in part, to the substantial variations in immunity observed in individuals with this syndrome.

circ-Amotl1 in extracellular vesicles derived from ADSCs improves wound healing by upregulating SPARC translation.

Aim: This study aims to explore the mechanism of circ- AMOT-like protein 1 (Amotl1) in extracellular vesicles (Evs) derived from adipose-derived stromal cells (ADSCs) regulating SPARC translation in wound healing process.

Methods: The morphology, wound healing rate of the wounds and Ki67 positive rate in mouse wound healing models were assessed by H&E staining and immunohistochemistry (IHC). The binding of IGF2BP2 and SPARC was verified by RNA pull-down.

Application of bacteriophage φPaP11-13 attenuates rat infection lesions by promoting keratinocytes apoptosis via inhibiting PI3K/Akt pathway.

Acne vulgaris caused by antibiotic-resistant () infection is difficult to treat conventionally. Phages have been suggested as a potential solution, but research on the mechanism of phage treatment is inadequate. This research investigates the underlying molecular mechanisms of phage φPaP11-13 attenuating -induced inflammation in rat models.

Anti-ferroptotic serves as a potential diagnostic and prognostic marker for hepatoblastoma.

Background: The incidence rate of hepatoblastoma (HB), which is the most prevalent malignant tumour among children, rises each year. According to recent studies, a number of neoplastic disorders and ferroptosis are intimately connected. This study aims to identify key ferroptosis-related genes in HB and explore new directions for the diagnosis and treatment of HB.

A Rhombus-Like Tetrameric Vanadoniobate Containing Pseudo-Sandwich-Type {Li ⊂ VO(NbO)} and Its Electrocatalytic Activity for the Selective Oxidation of Benzyl Alcohol.

Ongoing research on V-containing polyoxoniobates (PONbs) is driven by their diverse structures and potential applications. Although Lindqvist-type {NbO} is a widely used building block in PONbs, vanadoniobates based on {NbO} and/or its derivatives are still very limited. Herein, a discrete vanadoniobate, LiNaK[Li ⊂ VNbO]·45HO (), has been synthesized by a hydrothermal method, which shows a rhombus-like tetrameric structure composed of two {VO(NbO)} and two {Li ⊂ VO(NbO)} subunits derived from {NbO}.

Alternative Splicing of lncRNAs From SNHG Family Alters snoRNA Expression and Induces Chemoresistance in Hepatoblastoma.

Background & Aims: Hepatoblastoma (HB) is a common pediatric malignant liver tumor that is characterized by a low level of genetic mutations. Alternative splicing (AS) has been shown to be closely associated with cancer progression, especially in tumors with a low mutational burden. However, the role of AS in HB remains unknown.

exonic mutations induce abnormal biochemical activities and result in GCK-MODY.

Glucokinase-maturity-onset diabetes of the young (GCK-MODY; MODY2) is a rare genetic disorder caused by mutations in the glucokinase () gene. It is often under- or misdiagnosed in clinical practice, but correct diagnosis can be facilitated by genetic testing. In this study, we examined the genes of three patients diagnosed with GCK-MODY and tested their biochemical properties, such as protein stability and half-life, to explore the function of the mutant proteins and identify the pathogenic mechanism of GCK-MODY.

NETs Promote Inflammatory Injury by Activating Pathway in Acute Lung Injury.

Acute respiratory distress syndrome (ARDS) threatens the survival of critically ill patients, the mechanisms of which are still unclear. Neutrophil extracellular traps (NETs) released by activated neutrophils play a critical role in inflammatory injury. We investigated the role of NETs and the underlying mechanism involved in acute lung injury (ALI).

Ecological water, a new focus of China's water management.

Water set aside for environmental purposes is now the fastest-growing category of water use in China. Since 2000 this 'ecological water' (EcoW) has grown to make up 5 % of the total water allocation (around 30 billion m of water). This paper provides the first substantial review of the history, definition, and policy rationale for EcoW in China, and allows us to compare the Chinese program with elsewhere.

Phase separation of YAP mediated by coiled-coil domain promotes hepatoblastoma proliferation via activation of transcription.

Aim And Background: Yes-associated protein (YAP), a key transcriptional co-activator associated with cell fate and tumor progression, has been reported to be a powerful driver of hepatoblastoma (HB). In this study, we investigated the mechanism underlying oncogenic role of YAP in HB.

Methods: The expression of YAP in HB tissues was measured through WB and qRT-PCR.

RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor prognosis. Reprogramming of amino acid metabolism is one of the characteristics of PDAC, in which arginine metabolism is significantly altered in PDAC cells and is involved in important signaling pathways. Current studies have identified arginine deprivation as a potential strategy for PDAC treatment.

SNORA14A inhibits hepatoblastoma cell proliferation by regulating SDHB-mediated succinate metabolism.

Hepatoblastoma (HB) is the most common paediatric liver malignancy. Dysregulation of small nucleolar RNAs (snoRNAs) is a critical inducer of tumour initiation and progression. However, the association between snoRNAs and HB remains unknown.

{V } Ring Sandwiched Polyoxoniobate as Molecular Electrocatalyst for Oxidant-Free Synthesis of Sulfoxides.

Electrocatalytic oxidation of organic molecules to value-added chemicals has attracted recent attention. Although a series of transition metal based electrocatalytic materials have been developed, the lack of precise structure information generates great challenges in understanding the catalytic mechanism at a molecular level. Herein, we present the synthesis and characterization of a molecular electrocatalyst, Na K H [(VO) (α-TeNb O ) ] ⋅ 31H O ⋅ 2.

[Genetic features of a case with mosaic ring chromosome 4 and a review of the literature].

Objective: To explore the genetic basis, clinical phenotype and pathogenesis for a child with mosaicism ring chromosome 4.

Methods: Clinical data of the child was collected. Peripheral blood chromosomal karyotype G banding analysis, chromosomal microarray analysis (CMA), fluorescence in situ hybridization (FISH) were carried out for the child, in addition with a review of the literature.

Effect of momethasone furoate combined with loratadine and montelukast sodium on inflammatory factors and pulmonary function in children with allergic rhinitis.

Objective: To compare the effects of mometasone furoate in combination with loratadine and montelukast sodium on inflammatory factors and pulmonary function in children with allergic rhinitis (AR).

Methods: In this retrospective study, a total of 89 children with AR admitted to our hospital from March 2020 to October 2021 were enrolled. Among them, 47 children who received mometasone furoate combined with loratadine were designated group A, while the other 42 with mometasone furoate combined with montelukast sodium were group B.

Synergistic Hypolipidemic Effects and Mechanisms of Phytochemicals: A Review.

Hyperlipidemia, a chronic disorder of abnormal lipid metabolism, can induce obesity, diabetes, and cardiovascular and cerebrovascular diseases such as coronary heart disease, atherosclerosis, and hypertension. Increasing evidence indicates that phytochemicals may serve as a promising strategy for the prevention and management of hyperlipidemia and its complications. At the same time, the concept of synergistic hypolipidemic and its application in the food industry is rapidly increasing as a practical approach to preserve and improve the health-promoting effects of functional ingredients.

Zein-Based Nanomedicines for Synergistic Chemodynamic/Photodynamic Therapy.

Current cancer treatment is not only limited to monotherapy but is also influenced by limited drug delivery options. Combined chemokinetic-photokinetic therapy has great promise in enhancing anticancer effects. Meanwhile, zein has superior self-assembly properties and can be loaded with photosensitizers.

Controllable Assembly of Vanadium-Containing Polyoxoniobate-Based Materials and Their Electrocatalytic Activity for Selective Benzyl Alcohol Oxidation.

During the controllable synthesis of two vanadium-containing Keggin-type polyoxoniobates (PONbs), [Ni(en)][PNbO(VO)](OH)·18HO () and [Ni(en)][PNbO(VO)]∙17HO (, en = ethylenediamine) are realized by changing the vanadium source and hydrothermal temperature. Compounds and have been thoroughly characterized by single-crystal X-ray diffraction analysis, FT-IR spectra, X-ray photoelectron spectrum (XPS), powder X-ray diffraction (PXRD), etc. Compound contains a penta-capped Keggin-type polyoxoniobate {PNbO(VO)}, which is connected by adjacent [Ni(en)] units into a three-dimensional (3D) organic-inorganic framework, representing the first nickel complexes connected vanadoniobate-based 3D material.

IL-27 improves adoptive CD8 T cells' antitumor activity via enhancing cell survival and memory T cell differentiation.

IL-27 is an anti-inflammatory cytokine that triggers enhanced antitumor immunity, particularly cytotoxic T lymphocyte responses. In the present study, we sought to develop IL-27 into a therapeutic adjutant for adoptive T cell therapy using our well-established models. We have found that IL-27 directly improved the survival status and cytotoxicity of adoptive OT-1 CD8 T cells in vitro and in vivo.