Publications by authors named "Zhen Long Zhao"
Background: Thyroid nodule rupture (TNR) is a rare and severe complication after thermal ablation (TA), mostly from benign thyroid nodules (BTN).
Objective: To summarize the incidence of TNR after TA and analyze the causes and prevention strategies.
Materials And Methods: This retrospective study enrolled 3971 patients who underwent TA for BTN from January 2014 to March 2024.
Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation.
Int J Hyperthermia
December 2024
Article Synopsis
- The study aimed to assess how different levels of thyroid-stimulating hormone (TSH) affect tumor progression and survival in patients with early-stage papillary thyroid cancer treated with microwave ablation (MWA).
- It analyzed the medical records of 525 patients, categorizing them into uni-focal (U-PTC) and multifocal (M-PTC) groups based on TSH levels after treatment, and observed the rates of tumor progression and survival outcomes.
- Results indicated that lower TSH levels in U-PTC patients correlated with higher tumor progression rates and reduced progression-free survival compared to medium and high TSH levels, whereas M-PTC patients showed no significant relationship between TSH levels and progression.
Objectives: This study aimed to evaluate the long-term efficacy and safety of microwave ablation (MWA) for solitary T1N0M0 papillary thyroid carcinoma (PTC) and compare them between T1a and T1b disease.
Materials And Methods: This retrospective study included 136 patients with solitary T1N0M0 PTC who were treated with MWA and followed up for more than 5 years. Outcomes were compared between patients with T1a and T1b disease.
Article Synopsis
- Thermal ablation (TA) is an effective treatment for benign thyroid nodules (BTNs), but the study seeks to determine the optimal maximum diameter (MD) for effective results.
- Analyzing data from 639 BTNs, the study finds that the complete disappearance rate is significantly linked to the MD, with an optimal threshold identified at 25.0 mm.
- Results show that BTNs larger than 25.0 mm have a lower chance of complete disappearance and a higher rate of complications compared to smaller nodules.
Article Synopsis
- The study aimed to evaluate the feasibility, efficacy, and safety of microwave ablation for treating follicular thyroid neoplasms.
- It involved 74 patients, achieving a 100% technical success rate and significant reduction in nodule size and volume over 24 months, with no adverse changes in thyroid function.
- Results indicate that microwave ablation is an effective and safe treatment option, with low rates of recurrence and complications.
Objective: To evaluate the efficacy and safety of thermal ablation in treating solitary low-risk T2N0M0 papillary thyroid cancer (PTC) and compare the outcomes of microwave ablation (MWA) and radiofrequency ablation (RFA).
Materials And Methods: This retrospective, single center study involved 34 patients (age: 40.0 ± 13.
Influence of maximum diameter on fine-needle aspiration biopsy outcomes in ACR TI-RADS 5 thyroid nodules.
Front Endocrinol (Lausanne)
May 2024
Article Synopsis
- * A retrospective analysis of 280 TR5 nodules revealed that larger nodules (MD ≥ 6.2 mm) were more likely to yield probably malignant (PM) outcomes compared to smaller ones, with a significant difference in MD between PM and probably benign (PB) groups.
- * The findings suggest that an MD threshold of 6.2 mm is optimal for deciding when to perform FNA in TR5 nodules, as larger nodules have a higher probability
Background Microwave ablation (MWA) is currently under preliminary investigation for the treatment of multifocal papillary thyroid carcinoma (PTC) and has shown promising treatment efficacy. Compared with surgical resection (SR), MWA is minimally invasive and could preserve thyroid function. However, a comparative analysis between MWA and SR is warranted to draw definitive conclusions.
View Article and Find Full Text PDFObjective: To evaluate the complications associated with microwave ablation (MWA) in treating persistent/recurrent hyperparathyroidism (HPT) post-surgical or ablative treatments.
Materials And Methods: From January 2015 to December 2022, 87 persistent/recurrent HPT patients (primary HPT [PHPT]: secondary HPT [SHPT] = 13:74) who underwent MWA after surgical or ablative treatment were studied. Grouping was based on ablation order (initial vs.
Rationale And Objectives: To evaluate the feasibility, efficiency, and safety of microwave ablation (MWA) for multifocal papillary thyroid microcarcinoma (PTMC).
Methods: This was a retrospective study, and the data of patients who underwent MWA for multifocal PTMC from October 2016 to December 2021 were reviewed. After ablation, the changes in tumor size and volume, as well as the rates of technical success, tumor disappearance, disease progression, and complications, were assessed.
Article Synopsis
- - The study aims to compare the health-related quality of life (HRQoL) between patients with T1N0M0 papillary thyroid carcinoma who underwent microwave ablation (MWA) and those who had total thyroidectomy (TT).
- - Researchers analyzed 180 patients, equally divided into two groups, using quality of life questionnaires (EORTC QLQ-C30 and THYCA-QoL) to assess HRQoL scores.
- - Results showed that the MWA group had significantly better quality of life scores in multiple areas compared to the TT group, suggesting MWA could be a favorable alternative to TT for these patients.
Article Synopsis
- The study aimed to evaluate the safety of a new hydrodissection technique during microwave ablation (MWA) for secondary hyperparathyroidism (SHPT) by comparing improved hydrodissection to traditional methods.
- Data from 337 patients revealed that the risk of hoarseness, a common complication from nerve injury, was significantly lower in the improved hydrodissection group (6.9%) versus the traditional group (13.0%).
- Additionally, patients in the improved group recovered from hoarseness in a median time of 2 months compared to 6 months for those in the traditional group, suggesting the improved technique is safer without compromising technical effectiveness.
Article Synopsis
- The study investigates the safety and efficacy of microwave ablation (MWA) in patients with multifocal papillary thyroid carcinoma (M-PTC) compared to those with unifocal papillary thyroid carcinoma (U-PTC), using data from 504 patients over five years.
- Results showed that while the complete ablation was achieved in all cases, the tumour disappearance rate was significantly lower and slower for M-PTC patients compared to U-PTC, but the overall safety and complication rates were comparable between the two groups.
- In conclusion, MWA is an effective and safe treatment for selected M-PTC patients, with clinical outcomes similar to those with U-PTC
Article Synopsis
- The study aimed to evaluate the safety and effectiveness of a new hydrodissection technique during microwave ablation for treating papillary thyroid carcinoma (PTC).
- Data from 341 patients were analyzed, comparing traditional hydrodissection with an improved method targeting perithyroidal fascial spaces, focusing on complications and recovery outcomes.
- The improved technique resulted in fewer cases of hoarseness due to nerve injury and a quicker recovery time, while both methods showed no significant difference in tumor disappearance rates or local recurrence during follow-up.
Purpose: To study the feasibility, safety, and effectiveness of microwave ablation (MWA) in patients with multifocal papillary thyroid microcarcinoma (PTMC).
Materials And Methods: This retrospective study included patients who underwent MWA for multifocal PTMC (number of nodules ≤3). A total of 44 patients were included, and the mean age was 43 years (SD ± 11).
Changes in Thyroid Antibodies after Microwave Ablation of Thyroid Nodules.
Int J Endocrinol
September 2022
Purpose: Microwave ablation (MWA) is a minimally invasive method for the thermal ablation of benign thyroid nodules and papillary thyroid cancer (PTC) and has shown promising results. The aim of this study was to investigate the impact of MWA on thyroid antibodies and associated influencing factors.
Materials And Methods: A total of 119 patients, including 69 with benign thyroid nodules and 50 with PTC, underwent MWA between June 2019 and June 2021.
Article Synopsis
- Microwave ablation (MWA) is being examined as a less invasive treatment option for papillary thyroid carcinoma (PTC) compared to traditional surgical resection (SR), particularly for cases classified as T1N0M0.
- A study analyzing 1029 patients treated with either MWA or SR found no significant differences in disease progression rates and major complications between the two methods, although MWA required less blood loss and a shorter procedure time.
- The outcomes indicate that both treatments are comparable in effectiveness and safety for managing solitary T1a and T1b PTC, with MWA having the added benefits of being less invasive.
Objective: To compare the clinical outcomes between microwave ablation (MWA) and parathyroidectomy (PTX) for the treatment of primary hyperparathyroidism (pHPT).
Materials And Methods: This retrospective study enrolled 212 patients with pHPT treated by either MWA (MWA group) or PTX (PTX group) from January 2015 to October 2020. The baseline data were balanced through propensity score matching.
Context: Recurrent laryngeal nerve (RLN) injury is a complication of thermal thyroid nodule treatment.
Objective: We investigated the influencing factors of RLN injury in patients who underwent thermal ablation of thyroid nodules.
Methods: The data of 1004 patients (252 male, 752 female; median age 44 years) who underwent thermal thyroid nodule ablation were retrospectively reviewed.
Article Synopsis
- The study assessed the use of microwave ablation (MWA) as a treatment for T1N0M0 papillary thyroid carcinoma (PTC) with capsular invasion, evaluating its feasibility, efficiency, and safety over a period from August 2015 to January 2020 with data from 69 cases.
- Results showed that MWA successfully achieved complete ablation in all cases, with a significant percentage of nodules disappearing during follow-up, no local recurrence detected, and only a small incidence of complications related to the procedure.
- The findings indicate that MWA is a technically feasible and safe method for treating this type of thyroid cancer, showing promising outcomes and minimal adverse effects over an average follow-up period of 26
Cervical lymph node metastasis (CLNM) is common in patients with papillary thyroid carcinoma (PTC), which is responsible for tumor staging and surgical strategy. The accurate preoperative identification of CLNM is essential. In this study, twenty consecutive patients with PTC received a parenchyma injection of Sonazoid followed by contrast enhanced ultrasound (CEUS) to identify CLNM.
View Article and Find Full Text PDFA feasibility study of microwave ablation for papillary thyroid cancer close to the thyroid capsule.
Int J Hyperthermia
September 2021
Background: To evaluate the feasibility, efficiency, and safety of microwave ablation (MWA) for papillary thyroid carcinoma (PTC) close to the thyroid capsule.
Methods: The data of 106 cases who underwent thermal ablation from June 2014 to September 2020 were retrospectively analyzed. The mean follow-up time was 25 ± 11 months (range, 9-48 months).
Objective: To compare the clinical outcomes of microwave ablation (MWA) and radiofrequency ablation (RFA) in the treatment of primary hyperparathyroidism (pHPT).
Method: This retrospective study included 104 pHPT patients treated by MWA or RFA between January 2015 and March 2020 in four centers. The clinical outcomes including effectiveness and complications were compared between the two groups.
Article Synopsis
- Ultrasound-guided thermal ablation, including microwave and radiofrequency ablation, is being studied as a treatment option for papillary thyroid microcarcinoma (PTMC) in a large patient cohort.
- A retrospective analysis of 725 patients revealed significant tumor size reduction after the procedure, with 71% experiencing complete disappearance of tumors within six months.
- Complications were relatively low, with 2.6% of patients affected, but the procedure proved to be an effective and safe alternative to surgery or active surveillance.