Publications by authors named "Zhen Li"

To analyze the outcome indicators of randomized controlled trial(RCT) of traditional Chinese medicine(TCM) in the treatment of non-severe community-acquired pneumonia(NSCAP), and to provide a basis for the design of NSCAP clinical trials and the construction of core outcome set. CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science were systematically searched from establishment to August 31, 2023. Two reviewers independently screened the literature, extracted data, and evaluated the risk of bias in the included studies.

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The cross-talk between lysosomes and mitochondria is crucial for keeping intracellular homeostasis and metabolic function, providing a promising approach for tumor therapy. Herein, we employed polyvinylpyrrolidone (PVP)-modified Cu-gallic acid (CuGA) complex nano-boosters for amplifying lysosomes-mitochondria cascaded damage, and thereby effectively inducing cuproptosis and pyroptosis of breast tumor cells to boost anti-tumor immunotherapy. The CuGA nano-boosters could hijack lysosomal iron to form a bimetallic catalyst Cu(Fe)GA in situ through ion-exchange reaction, and cause the release of Cu and metal ion dysregulation (i.

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Background: In recent years, daratumumab (DARA) has gained widespread use in the treatment of systemic light chain (AL) amyloidosis. In this study, we assessed the efficacy and safety of a DARA treatment strategy based on serum free light chain (sFLC) levels and non-fixed cycles.

Methods: The study included 123 patients with Al amyloidosis who received DARA at our center between July 2020 and September 2023.

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Saccharum officinarum (S. officinarum) and Saccharum spontaneum (S. spontaneum) are two fundamental species of modern sugarcane cultivars, exhibiting divergent tillering patterns crucial for sugarcane architecture and yield.

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Background: Recent phase III randomized controlled trials have demonstrated that first-line immune checkpoint inhibitors (ICIs) improve prognosis in advanced HER-2-negative gastric cancer patients with programmed death ligand 1 (PD-L1) combined positive score (CPS) higher than 5. However, these findings are not confirmed in real-world settings, and the benefits in PD-L1 CPS < 5 patients remain controversial.

Methods: In this multicenter, retrospective cohort study, data from across thirteen medical centers were analyzed by inverse probability of treatment weighting for matching, alongside univariate and multivariate COX proportional hazard regression models.

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Signal uniformity is crucial for reliable and quantifiable surface-enhanced Raman scattering (SERS) measurements. However, challenges arise due to the continuous impact of localized hottest spots and the coffee ring effect on signal uniformity. In response to this, we developed a platform featuring a hierarchical structure with Ag nanopores and microbowls (HANM) and incorporated superhydrophobic/superhydrophilic (SHB/SHL) treatments.

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The differences between the high-starch diet commonly used in rabbit farming and the natural feeding habits of rabbits may pose certain health risks. In our study, we replaced part of the starch in the feed with soybean oil and conducted a four-week feeding trial with weaned Rex rabbits. The results indicated that rabbits fed the oil-supplemented diet had a lower incidence of diarrhea, improved growth performance, and higher feed conversion efficiency, along with increased absorptive capacity of small intestine.

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High-temperature polymer capacitors with superior energy storage density are considerable and desirable components in advanced power pulse, electrical, and energy conversion systems. However, due to the π-π conjugated benzene ring structure, carriers migrate through polyimide (PI) chains, reducing discharge energy density () and charge-discharge efficiency (η) at high temperature. Here, the ether (-O-) and isopropylidene (-C(CH)-) groups are purposefully introduced into the position between the benzene rings to increase the conjugate angle in PI chains, and spatial folded chains are designed to impede charge transport at high temperature.

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This work aimed to investigate the effects of ultrasound assisted enzymatic deamidation by protein-glutaminase (PG) on the dispersion of myofibrillar protein (MP) in low-salt solutions. The solubility, structural characteristics, transmission electron microscopy, asymmetric-flow field-flow fractionation, steady shear rheological property and multiple light scattering of MP deamidated by PG (MP-PG) and MP pretreated with ultrasound followed by PG deamidation (MP-U-PG) were determined. Molecular docking and molecular dynamics (MD) simulations were used to estimate the interaction between PG and MP.

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Microbial communities, both on the surface and within fruit, play a crucial role in reducing postharvest diseases and maintaining fruit quality. This study investigated the effects of co-culture fermentation supernatant of Debaryomyces hansenii (Y) and Bacillus atrophaeus (T) on disease control and quality preservation of postharvest litchi fruit, while exploring the underlying mechanisms through microbiome profiling. The results indicated that Y + T treatment not only reduced decay percentage, weight loss, and pH increase but also preserved the pericarp cell integrity and reduced the lignin accumulation.

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Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that occur concurrently and increase the risk of cardiovascular disease. 3-mercaptopyruvate sulfurtransferase (MPST) is a cysteine-catabolizing enzyme that yields pyruvate and hydrogen sulfide (HS) and plays a central role in the regulation of energy homeostasis. Herein, we seek to investigate the role of MPST/HS in MetS and its cardiovascular consequences using a mouse model of the disease.

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Background: A demand exists for user-friendly patient-reported outcome measures for patients with inflammatory bowel disease (IBD). The IBD-Control Questionnaire has been recently developed to assess overall disease control from the patient's view but has not been available in China.

Methods: Translation and cultural adaption of the IBD-Control into Chinese was conducted through four steps (forward translation, backward translation, expert panel, and pilot testing).

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The interfacial incompatibility between lithium phosphorus oxynitride (LiPON) and anode greatly deteriorates the performance of thin-film all-solid-state supercapacitors (ASSSCs). This article investigates oxygen plasma treatment to improve the interface. Through appropriate plasma treatment, a LiO/LiPO composite layer is formed by replacing nitrogen with oxygen at the LiPON surface owing to strong reactivity of oxygen plasma.

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Genome editing based on programmable nucleases and donor DNA constructs permits introducing specific base-pair changes and complete transgenes or live-cell reporter tags at predefined chromosomal positions. A crucial requirement for such versatile genome editing approaches is, however, the need to co-deliver in an effective, coordinated and non-cytotoxic manner all the required components into target cells. Here, adenoviral (AdV) and adeno-associated viral (AAV) vectors are investigated as delivery agents for, respectively, engineered CRISPR-Cas9 nucleases and donor DNA constructs prone to homologous recombination (HR) or homology-mediated end joining (HMEJ) processes.

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Variants of the ACTG2 gene cause autosomal dominant ACTG2 visceral myopathy, a disorder of smooth muscle dysfunction of the bladder and gastrointestinal system. Bladder involvement can behave as fetal megacystis (FM). We report four prenatal cases of ACTG2 visceral myopathy.

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Objective: To assess the diagnostic efficiency of long-read sequencing (LRS) for the determination of CYP21A1P/CYP21A2 and TNXA/TNXB fusion genotypes among children with 21-hydroxylase deficiency (21-OHD) and explore their clinical characteristics.

Methods: LRS sequencing was carried out on 30 children diagnosed with 21-OHD at the Department of Endocrinology, Fujian Children's Hospital between November 2022 and September 2023 by clinical symptoms or conventional Sanger sequencing combined with multiple ligation-dependent probe amplification (MLPA). The results of the two methods were compared.

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Sample multiplexing is a common approach to reduce experimental cost and technical batch effect. Here, we present a protocol that for the first time allows the pooling of single nuclei from multiple biological samples prior to performing simultaneous single nuclei RNA-seq and ATAC-seq, which we term ltiplexed ltiome (MuMu). We describe steps for assembling the custom Tn5 transposome, performing the transposition reaction, nuclei pooling, sequencing library preparation, and sequencing data pre-processing.

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Bisphenols, as common industrial raw materials, are widely used in food packaging such as plastics. However, their migration and residue may affect the hormone secretion of the human body and then lead to health problems. Therefore, a low-cost, rapid and simple detection method that can simultaneously detect multiple bisphenols is very necessary.

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This study evaluated the role of probiotics in enhancing intestinal immunity and mitigating polystyrene nanoplastics (PS-NPs)-induced toxicity in grass carp (Ctenopharyngodon idella). Grass carp were fed probiotics (Bacillus subtilis, Bacillus velezensis, Lactobacillus reuteri, and Lactococcus lactis) for two weeks before being exposed to PS-NPs for five days. Probiotic pretreatment alleviated PS-NPs-induced intestinal damage, with Bacillus velezensis and Lactococcus lactis groups showing milder vacuolation and villus breakage than other groups.

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Cryptosporidium species can infect humans and more than 260 animal species, including 54 rodent species. However, data on the occurrence and genetic characterizations of Cryptosporidium spp. in laboratory rodents are limited.

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Objective: To explore the value of three-dimensional arterial spin labeling (ASL) and six diffusion magnetic resonance imaging (MRI) models in differentiating solid benign and malignant renal tumors.

Methods: This retrospective study included 89 patients with renal tumors. All patients underwent ASL and ZOOMit diffusion-weighted imaging (DWI) examinations and were divided into three groups: clear cell renal cell carcinoma (ccRCC), non-ccRCC, and benign renal tumors (BRT).

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Article Synopsis
  • This text references a correction to an article identified by the DOI number 10.3389/fendo.2024.1447750.
  • The correction likely addresses errors or inaccuracies found in the original publication.
  • It highlights the importance of maintaining accuracy and credibility in scientific literature.
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We demonstrate a technique for flexibly controlling subwavelength focusing and scanning, by using the Fourier translation property of a topology-preserved flat lens. The Fourier transform property of the flat lens enables converting an initial phase shift of light into a spatial displacement of its focus. The flat lens used in the technique exhibits a numerical aperture of 0.

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Article Synopsis
  • Graphene-based metamaterial sensors are highly sensitive tools for detecting food preservatives at low concentrations, particularly in the terahertz region.
  • The study presents an anapole resonance-based graphene metasurface sensor that leverages electrostatic doping to improve detection, specifically for sodium benzoate and potassium sorbate.
  • Results show that sodium benzoate has a stronger interaction with graphene due to its structure, leading to more significant amplitude and phase changes, which were analyzed further using continuous wavelet transform for better concentration differentiation.
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