Fabrication of Ultrahigh-Loading Dual Copper Sites in Nitrogen-Doped Porous Carbons Boosting Electroreduction of CO to CH Under Neutral Conditions.

Synthesis of high-loading atomic-level dispersed catalysts for highly efficient electrochemical CO reduction reaction (eCORR) to ethylene (CH) in neutral electrolyte remain challenging tasks. To address common aggregation issues, a host-guest strategy is employed, by using a metal-azolate framework (MAF-4) with nanocages as the host and a dinuclear Cu(I) complex as the guest, to form precursors for pyrolysis into a series of nitrogen-doped porous carbons (NPCs) with varying loadings of dual copper sites, namely NPC-Cu-21 (21.2 wt%), NPC-Cu-11 (10.

Efficient Capture and Electroreduction of Dilute CO into Highly Pure and Concentrated Formic Acid Aqueous Solution.

High-purity CO rather than dilute CO (15 vol %, CO/N/O = 15:80:5, v/v/v) similar to the flue gas is currently used as the feedstock for the electroreduction of CO, and the liquid products are usually mixed up with the cathode electrolyte, resulting in high product separation costs. In this work, we showed that a microporous conductive Bi-based metal-organic framework (, HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene) can not only efficiently capture CO from the dilute CO under high humidity but also catalyze the electroreduction of the adsorbed CO into formic acid with a high current density of 80 mA cm and a Faradaic efficiency of 90% at a very low cell voltage of 2.6 V.

Corrigendum: Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease.

[This corrects the article DOI: 10.3389/fnagi.2023.

Highly Efficient Electroreduction of CO to Ethanol via Asymmetric C-C Coupling by a Metal-Organic Framework with Heterodimetal Dual Sites.

The electroreduction of CO into value-added liquid fuels holds great promise for addressing global environmental and energy challenges. However, achieving highly selective yielding of multi-carbon oxygenates through the electrochemical CO reduction reaction (eCORR) is a formidable task, primarily due to the sluggish asymmetric C-C coupling reaction. In this study, a novel metal-organic framework () with unprecedented heterometallic Sn···Cu dual sites (namely, a pair of SnNO and CuN sites bridged by -N atoms) was designed to overcome this limitation.

Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease.

Introduction: Early diagnosis of Parkinson's disease (PD) remains challenging. It has been suggested that abnormal brain iron metabolism leads to excessive iron accumulation in PD, although the mechanism of iron deposition is not yet fully understood. Ferritin and transferrin receptor (TfR) are involved in iron metabolism, and the exosome pathway is one mechanism by which ferritin is transported and regulated.

Dicopper(I) Sites Confined in a Single Metal-Organic Layer Boosting the Electroreduction of CO to CH in a Neutral Electrolyte.

It is challenging and important to achieve high performance for an electrochemical CO reduction reaction (eCORR) to yield CH under neutral conditions. So far, most of the reported active sites for eCORR to yield CH are single metal sites; the performances are far below the commercial requirements. Herein, we reported a nanosheet metal-organic layer in single-layer, namely, [Cu(obpy)] (, Hobpy = 1-[2,2']bipyridinyl-6-one), possessing dicopper(I) sites for eCORR to yield CH in a neutral aqueous solution.

"Ship-in-a-Bottle" Integration of Ditin(IV) Sites into a Metal-Organic Framework for Boosting Electroreduction of CO in Acidic Electrolyte.

The electrochemical CO reduction reaction (eCORR) under acidic conditions has become a promising way to achieve high CO utilization because of the inhibition of undesirable carbonate formation that typically occurs under neutral and alkaline conditions. Herein, unprecedented and highly active ditin(IV) sites were integrated into the nanopores of a metal-organic framework, namely , by a "ship-in-a-bottle" strategy. delivers nearly 100% formic acid Faradaic efficiency at an industry current density of 260 mA cm with a high single-pass CO utilization of 95% in an acidic solution (pH = 1.

Cyclic Trinickel(II) Clusters in a Metal-Azolate Framework for Efficient Overall Water Splitting.

Herein, a stable metal-azolate framework with cyclic trinickel(II) clusters, namely [Ni (μ -O)(BTPP)(OH)(H O) ] (Ni-BTPP, H BTPP=1,3,5-tris((1H-pyrazol-4-yl)phenylene)benzene), achieved a current density of 50 mA cm at a cell voltage of 1.8 V in 1.0 M KOH solution, while the current density of 20%Pt/C@NF||IrO @NF is just 35.

Atomically Dispersed Dual-Metal Sites Showing Unique Reactivity and Dynamism for Electrocatalysis.

The real structure and in situ evolution of catalysts under working conditions are of paramount importance, especially for bifunctional electrocatalysis. Here, we report asymmetric structural evolution and dynamic hydrogen-bonding promotion mechanism of an atomically dispersed electrocatalyst. Pyrolysis of Co/Ni-doped MAF-4/ZIF-8 yielded nitrogen-doped porous carbons functionalized by atomically dispersed Co-Ni dual-metal sites with an unprecedented N8V4 structure, which can serve as an efficient bifunctional electrocatalyst for overall water splitting.

A Conductive Dinuclear Cuprous Complex Mimicking the Active Edge Site of the Copper(100)/(111) Plane for Selective Electroreduction of CO to CH at Industrial Current Density.

Inorganic solids are a kind of important catalysts, and their activities usually come from sparse active sites, which are structurally different from inactive bulk. Therefore, the rational optimization of activity depends on studying these active sites. Copper is a widely used catalyst and is expected to be a promising catalyst for the electroreduction of CO to CH.

Single-Product Faradaic Efficiency for Electrocatalytic of CO to CO at Current Density Larger than 1.2 A cm in Neutral Aqueous Solution by a Single-Atom Nanozyme.

Electroreduction of CO to CO is a promising approach for the cycling use of CO , while it still suffers from impractical current density and durability. Here we report a single-atom nanozyme (Ni-N -C) that achieves industrial-scale performance for CO -to-CO conversion with a Faradaic efficiency (FE) exceeded 97 % over -0.8--2.

A Porous π-π Stacking Framework with Dicopper(I) Sites and Adjacent Proton Relays for Electroreduction of CO to C Products.

Crystalline porous materials sustained by supramolecular interactions (, π-π stacking interactions) are a type of molecular crystals showing considerable stability, but their applications are rarely reported due to the high difficulty of their construction. Herein, a stable π-π stacking framework formed by a trinuclear copper(I) compound [Cu(HBtz)(Btz)Cl] (, HBtz = benzotriazole) with pyrazolate-bridged dicopper(I) sites is reported and employed for electrochemical CO reduction, showing an impressive performance of 73.7 ± 2.

A Stable and Conductive Covalent Organic Framework with Isolated Active Sites for Highly Selective Electroreduction of Carbon Dioxide to Acetate.

Electroreduction of CO to acetate provides a promising strategy to reduce CO emissions and store renewable energy, but acetate is usually a by-product. Here, we show a stable and conductive two-dimensional phthalocyanine-based covalent-organic framework (COF) as an electrocatalyst for reduction of CO to acetate with a single-product Faradaic efficiency (FE) of 90.3(2)% at -0.

Comparing the diagnostic performance of radiotracers in prostate cancer biochemical recurrence: a systematic review and meta-analysis.

Objectives: To systematically assess the early detection rate of biochemical prostate cancer recurrence using choline, fluciclovine, and PSMA.

Methods: Under the guidance of the Preferred Reporting Items for Systematic reviews and Meta-Analysis Diagnostic Test Accuracy guidelines, literature that assessed the detection rates (DRs) of choline, fluciclovine, and PSMA in prostate cancer biochemical recurrence was searched in PubMed and EMBASE databases for our systematic review from 2012 to July 15, 2021. In addition, the PSA-stratified performance of detection positivity was obtained to assess the DRs for various methods, including fluciclovine, PSMA, or choline PET/CT, with respect to biochemical recurrence based on different PSA levels.

A Cu(111)@metal-organic framework as a tandem catalyst for highly selective CO electroreduction to CH.

Here, we report an improved tandem catalytic mechanism for electroreduction of CO to CH. Cu(111) nanoparticles with an average size of 5.5 ± 0.

Rare monolocular intrahepatic biliary cystadenoma: A case report.

Background: Intrahepatic biliary cystadenoma (IBC) is a rare benign hepatic tumor that is often misdiagnosed as other hepatic cystic diseases. Therefore, imaging examinations are required for preoperative diagnosis. Contrast-enhanced ultrasound (CEUS) has gained increasing popularity as an emerging imaging modality and it is considered the primary method for screening IBC because of its specificity of performance.

Development and Validation of a F-FDG PET-Based Radiomic Model for Evaluating Hypermetabolic Mediastinal-Hilar Lymph Nodes in Non-Small-Cell Lung Cancer.

Background: Accurate evaluation of lymph node (LN) status is critical for determining the treatment options in patients with non-small cell lung cancer (NSCLC). This study aimed to develop and validate a F-FDG PET-based radiomic model for the identification of metastatic LNs from the hypermetabolic mediastinal-hilar LNs in NSCLC.

Methods: We retrospectively reviewed 259 patients with hypermetabolic LNs who underwent pretreatment F-FDG PET/CT and were pathologically confirmed as NSCLC from two centers.

Thalidomide Reduces Activation of Murine Pancreatic Stellate Cells by Inhibiting the TGF-β/Smad Pathway.

Objective: The aim of this study was to investigate the effects and mechanism of thalidomide on pancreatic stellate cell (PSC) activation in mice and to find the optimal timing of thalidomide administration.

Methods: PSCs, isolated from mouse pancreas tissue, were divided into five groups with specific treatments: (A) control PSCs (PSC), (B) PSCs induced by TGF-β1 (PSC+TGF-β1), (C) PSCs induced by TGF-β1 followed by thalidomide (PSC+TGF-β1+Thalidomide), (D) PSCs receiving TGF-β1 and thalidomide simultaneously (PSC+(TGF-β1+Thalidomide)), and (E) PSCs treated with thalidomide only (PSC+Thalidomide). We measured the effects of thalidomide on PSC activation by detecting the expression of α-SMA, collagen type I, and the TGF-β/Smad pathway through quantitative real-time PCR and Western blot analysis.

Distinguishing between benign and malignant breast lesions using diffusion weighted imaging and intravoxel incoherent motion: A systematic review and meta-analysis.

Purpose: We sought to evaluate the diagnostic performance of diffusion weighted imaging (DWI) and intravoxel incoherent motion (IVIM) for distinguishing between benign and malignant breast tumors by performing a meta-analysis.

Methods: We comprehensively searched the electronic databases PubMed and Embase from January 2000 to April 2020 for studies in English. Studies were included if they reported the sensitivity and specificity for identifying benign and malignant breast lesions using DWI or IVIM.

The minimal seesaw and leptogenesis models.

Given its briefness and predictability, the minimal seesaw-a simplified version of the canonical seesaw mechanism with only two right-handed neutrino fields-has been studied in depth and from many perspectives, and now it is being pushed close to a position of directly facing experimental tests. This article is intended to provide an up-to-date review of various phenomenological aspects of the minimal seesaw and its associated leptogenesis mechanism in neutrino physics and cosmology. Our focus is on possible flavor structures of such benchmark seesaw and leptogenesis scenarios and confronting their predictions with current neutrino oscillation data and cosmological observations.

Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7.

PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7.

Feasibility of customizing titanium implant with three-dimensional CT imaging of low dose in skull.

Object: To explore the feasibility and practicability of making virtual three-dimensional model of skull defect and customizing titanium implant by skull three-dimensional CT examination of low dose.

Methods: Sixty patients with skull defects who underwent skull three-dimensional CT before cranioplasty were randomly divided into 4 groups: group A (conventional dose 120 peak Kilovoltage (kVp), 150 tube current time product (mAs)), low dose group B (120 kVp, 50 mAs), low dose group C (100 kVp, 50 mAs), low dose group D (100 kVp, 30 mAs). After the scanning, we compared radiation doses and image quality among the groups.

The Diagnostic Accuracy of Magnetic Resonance Imaging in Restaging of Rectal Cancer After Preoperative Chemoradiotherapy: A Meta-Analysis and Systematic Review.

Objective: To evaluate the overall diagnostic value of magnetic resonance imaging (MRI) in restaging of rectal cancer after preoperative chemoradiotherapy based on qualified studies.

Methods: PubMed, Cochrane, and EMBASE database were searched by the index words to identify the qualified studies, and relevant literature sources were also searched. The latest research was done in April 2019.

Functional characterization of three flavonoid glycosyltransferases from .

is an important traditional medicinal herb in South and Southeast Asian countries with diverse pharmacological activities that contains various flavonoids and flavonoid glycosides. Glycosylation can transform aglycones into more stable, biologically active and structurally diverse glycosides. Here, we report three glycosyltransferases from the leaves of (ApUFGTs) that presented wide substrate spectra for flavonoid glycosylation and exhibited multi-site glycosylation on the substrate molecules.