Publications by authors named "Zhen Bin Zhang"
Article Synopsis
- Lysine (K) plays a crucial role in designing crosslinkers and analyzing protein interactions in "shotgun" proteomics, but analyzing K-containing peptides has been challenging due to ineffective enrichment methods.
- A new method called HYTARP utilizes a hydrophobic-tag-labeling reagent (C10-S-S-NHS) combined with reversed-phase chromatography to effectively enrich and identify K-containing peptides from complex samples, demonstrating a labeling efficiency of 96% in HeLa cell protein digests.
- The enriched K-labeled peptides constituted 90% of the total enriched peptides, significantly improving analysis capabilities for low-abundance proteins and enhancing identification coverage in complex proteomics.
Article Synopsis
- This study examines the stereochemistry and antifungal effectiveness of the chiral triazole fungicide metconazole, identifying its stereoisomers and their relative bioactivities against specific fungal pathogens.
- The (1S, 5R)-metconazole is the most effective isomer, showing significantly higher fungicidal activity compared to others, particularly (1R, 5S)-metconazole, by 13.9-23.4 times.
- The research also explores enantioselective metabolism and binding interactions with Cytochrome P450 CYP51B, revealing that (1S, 5R)-metconazole demonstrates the strongest binding affinity and distinct metabolic profiles compared to (1R,
Article Synopsis
- The study investigated the effects of dehydrocostus lactone on BON-1 cancer cells, focusing on its ability to reduce cell growth and explore the underlying mechanisms.
- Various techniques such as MTT assays, fluorescence microscopy, and flow cytometry were used to assess cytotoxicity, cellular changes, and apoptosis induced by the compound.
- The findings revealed that dehydrocostus lactone significantly inhibited BON-1 cell proliferation in a time and concentration-dependent manner, leading to mitochondrial dysfunction, apoptosis, and cell cycle arrest, suggesting its potential in treating gastrinoma cancer.
Article Synopsis
- - The study investigates shock waves in a one-dimensional bead chain, revealing that bead velocities oscillate around the piston velocity when the shock hits.
- - Maximum bead velocity is capped at 2 times the piston velocity when there is no initial overlap, but if there is some overlap, it exceeds the piston velocity but remains below the 2x limit.
- - The research highlights how shock velocity is influenced by both piston velocity and initial overlap, making significant advancements over prior findings from Phys. Rev. Lett. 108, 058001 (2012).
[Preparation of δ-Valerolactone and Its Spectral Analysis].
Guang Pu Xue Yu Guang Pu Fen Xi
October 2015
Article Synopsis
- The study developed a catalyst composed of CuO/ZnO/Al2O3 using a sol-gel method and tested its effectiveness in converting 1,5-Pentanediol to δ-valerolactone through a gas-phase catalytic dehydrogenation process.
- Techniques like XRD and FTIR were utilized to analyze the catalyst's structure and the chemical properties of the products involved, revealing high purity of δ-valerolactone.
- The research highlighted the catalyst's deactivation and potential stability issues of δ-valerolactone, pointing out the need for strategies to enhance its stability for future industrial applications.
The chiral selector 6-azido-2, 3-di(p-chlorophenylcarbamoylated) cellulose was synthesized and further chemically immobilized onto 5-μm amino functionalized spherical porous silica gel. It was used as chiral stationary phase in high-performance liquid chromatography. Thirty racemates were successfully separated into enantiomers in either normal phase mode or reversed-phase mode.
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- The study focuses on creating new chiral stationary phases by chemically immobilizing a specific β-cyclodextrin derivative onto amino-functionalized silica gel with varying pore and particle sizes.
- It examines how different silica gel characteristics affect the amount of immobilized material, column performance, and the ability to separate enantiomers.
- Results showed that smaller pore sizes and finer silica gel particles (3 μm) improved retention, resolution, and overall performance in separating racemates in both separation modes.
Article Synopsis
- The study evaluates the outcomes of esophagectomy combined with extended 2-field lymph node dissection in 1,690 patients with esophageal cancer from 1987 to 2008.
- Lymph node metastasis was observed in 42.2% of patients, with significant rates in both thoracic and abdominal areas, while postoperative complications occurred in 16.4% of cases, primarily pulmonary issues.
- Survival rates were reported at 88.2% for one year, decreasing to 30.8% by ten years, with a notable disparity between patients with and without lymph node metastasis in terms of survival.
Article Synopsis
- A novel derivative of cyclodextrin was developed and attached to amino-silica gel, creating a new chiral stationary phase for high performance liquid chromatography (HPLC).
- The addition of p-chlorophenyl groups to the cyclodextrin enhances interactions with aromatic analytes, which is crucial for separating different enantiomers.
- Successful separation of 11 piperazine derivatives and six racemates was achieved using this new chiral stationary phase in both normal and reversed phase HPLC settings.
Article Synopsis
- - This study examines how regional lymph node metastasis affects the prognosis of thoracic esophageal carcinoma and seeks to establish guidelines for lymphadenectomy during the Ivor-Lewis procedure.
- - Analyzing data from 1,412 patients, the study found that 38.74% had lymph node metastasis, with varying rates depending on the lymph node location and tumor stage, showing significantly higher rates in advanced-stage patients.
- - The research highlights the importance of proper lymphadenectomy to improve surgical outcomes and provides insights on which lymph nodes are most affected by metastasis.
[Right para-tracheal triangle lymphadenectomy for esophageal carcinoma].
Zhonghua Zhong Liu Za Zhi
July 2003
Objective: To investigate the incidence of lymph node metastasis (LNM) in the right para-tracheal triangle (RPT) of esophageal carcinoma patients and the technique of dissection.
Methods: On the top of double mediastinal and abdominal lymphadenectomy, 333 esophageal carcinoma patients received RPT lymphadenectomy through the right pleural apical approach from 1990 to 2001.
Results: In these 333 patients, the lymph node metastasis (LNM) rate in the RPT was 36.