FOXC1 promotes EMT and colorectal cancer progression by attracting M2 macrophages via the TGF-β/Smad2/3/snail pathway.

Colorectal cancer is a highly prevalent and deadly malignancy worldwide. Current treatment strategies, including surgery, chemotherapy, and targeted therapy, still face limitations due to recurrence and metastasis. By conducting a weighted gene coexpression network analysis on gene expression data from The Cancer Genome Atlas, we pinpointed critical genes linked to M2 macrophages and tumor metastasis.

Superficial temporal artery-to-middle cerebral artery side-to-side microvascular anastomosis using the in-situ intraluminal suturing technique.

Background: Superficial temporal artery (STA)-middle cerebral artery (MCA) side-to-side microvascular anastomosis can achieve the same clinical effects as traditional STA-MCA end-to-side anastomosis in extracranial-intracranial revascularization surgery, furthermore, STA-MCA side-to-side anastomosis has the lower risk of postoperative cerebral hyperperfusion syndrome (CHS) and the potential to recruit all scalp arteries as the donor sources via self-regulation. Therefore, STA-MCA side-to-side microvascular anastomosis seems to be a revascularization strategy superior to traditional STA-MCA end-to-side anastomosis. In this study, we presented seven cases in which a STA-MCA side-to-side microvascular anastomosis was performed with a 4-5 mm long arteriotomy using the in-situ intraluminal suturing technique.

Microbial community assembly and co-occurrence patterns in Sanmen bay: A comparative analysis before and after nuclear power plant operation.

The limited availability of historical data has resulted in the ongoing debate regarding the short-term effects of thermal discharge from nuclear power plants (NPPs) on microbial communities, including both prokaryotes and microeukaryotes. This study focused on the co-occurrence patterns, assembly processes, and community functions in the eutrophic coastal waters of Sanmen Bay (SMB) before and after NPP operation. Gammaproteobacteria and Alphaproteobacteria were the dominant prokaryotic taxa, while Dinoflagellates consistently maintained their prevalence in SMB.

Curcumin-release antibacterial dressings with antioxidation and anti-inflammatory function for diabetic wound healing and glucose monitoring.

Diabetic wound healing remains a challenge due to high levels of oxidative stress, excessive inflammation, and bacterial infection. Smart dressings loaded with natural active monomers are proving to be effective strategies for enhancing diabetic wound healing. Herein, the bio-composites (PTIGA-Cur and PTIGA-Cur-Ag) with curcumin (Cur) responsive release were reported for promoting angiogenesis and diabetic wound repair, showing excellent anti-inflammatory, antioxidant, and antibacterial properties.

Metagenomic insights into the rapid recovery mechanisms of prokaryotic community and spread of antibiotic resistance genes after seawater disinfection.

Disinfectants, such as bleaching powder, are widely employed in marine aquaculture worldwide to control the bacterial pathogens and eliminate antibiotic resistance genes (ARGs). Nevertheless, the rapid recovery of prokaryotic community compositions (PCCs) after disinfection may significantly influence the overall efficacy of disinfection. Presently, little is known about the rapid recovery mechanisms of PCCs and its impact on the removal of ARGs in seawater.

Analysis of Differentially Expressed Murine miRNAs in Acute Myocardial Infarction and Target Genes Related to Heart Rate.

Objective: This study aims to investigate the expression profile of miRNAs significantly dysregulated after acute myocardial infarction (AMI) and their potential targets.

Methods: After the establishment of a mouse model of AMI, RNA was extracted from mouse infarcted myocardium. Paired-end sequencing was then performed using the Illumina NovaSeq 6000 system to explore the expression profile of miRNAs.

PDCD4 promotes inflammation/fibrosis by activating the PPAR‑γ/NF‑κB pathway in mouse atrial myocytes.

Fibrosis is the basis of structural remodeling in atrial fibrillation (AF), during which inflammation is crucial. Programmed cell death factor 4 (PDCD4) is a newly identified inflammatory gene, with unknown mechanisms of action in AF. The present study aimed to elucidate the effects of PDCD4 on the inflammation and structural remodeling of atrial myocytes.

Effects and Mechanisms of Different Types of Biochar on Heavy Metal Passivation during Sludge Composting.

The effects and mechanisms of the different types of biochar on heavy metal passivation are still not fully understood. This study compared the effects of three types of biochar on heavy metal passivation during sludge composting. Compared with composting without biochar, rice husk biochar was most effective for the passivation of Zn and Pb, with increased passivation rates of 1.

The effects of EFL wordlist and proficiency on vocabulary knowledge.

Introduction: The Gaokao Word List (GWL) in China serves as a guideline for learning L2 vocabulary, but there are few studies verifying its effect on university EFL learners' vocabulary knowledge.

Method: This study investigated the effects of the GWL and EFL proficiency on 66 Chinese university EFL learners' vocabulary knowledge by administering word recognition tests.

Results And Discussion: The results showed that: (1) the GWL had significant effects on participants' receptive vocabulary knowledge; (2) EFL proficiency had significant effects on participants' word recognition, without interaction with the GWL.

Elevated temperature alters bacterial community from mutualism to antagonism with : insights into the role of a novel species, sp. MS1.

Unlabelled: , a cosmopolitan diatom primarily inhabiting coastal ecosystems, exhibits a typically close yet variable relationship with heterotrophic bacteria. The increasing temperature of surface seawater is expected to substantially affect the viability and ecological dynamics of , potentially altering its relationship with bacteria. However, it remains unclear to what extent the elevated temperature could change these relationships.

XCR1: A promising prognostic marker that pinpoints targeted and immune-based therapy in hepatocellular carcinoma.

Objectives: The lymphotactin receptor X-C motif chemokine receptor 1 (XCR1) is an essential member of the chemokine receptor family and is related to tumor development and progression. Nevertheless, further investigation is required to explore its expression patterns, prognostic values, and functions related to target or immune therapies in patients with hepatocellular carcinoma (HCC).

Materials And Methods: The differential expression patterns of and its prognostic influences were performed through The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases.

The relationship between serum coagulation parameters and the recurrence of chronic subdural hematoma.

The aim is to investigate the relationship between serum coagulation parameters (PT, APTT, D-D and FDP) before hospitalization and recurrence of chronic subdural hematoma (CSDH). 236 patients with CSDH who were diagnosed for the first time and had complete medical records were followed up for at least 90 days. Fifty patients (21.

METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis.

Background: The regulatory role of N6-methyladenosine (m6A) modification in the onset and progression of cancer has garnered increasing attention in recent years. However, the specific role of m6A modification in pulmonary metastasis of colorectal cancer remains unclear.

Methods: This study identified differential m6A gene expression between  primary colorectal cancer and its pulmonary metastases using transcriptome sequencing and immunohistochemistry.

Overcoming cold tumors: a combination strategy of immune checkpoint inhibitors.

Immune Checkpoint Inhibitors (ICIs) therapy has advanced significantly in treating malignant tumors, though most 'cold' tumors show no response. This resistance mainly arises from the varied immune evasion mechanisms. Hence, understanding the transformation from 'cold' to 'hot' tumors is essential in developing effective cancer treatments.

Thermal stratification controls taste and odour compounds by regulating the phytoplankton community in a large subtropical water source reservoir (Xin'anjiang Reservoir).

2-Methylisoborneol (2-MIB) and geosmin are compounds released by algae that significantly degrade reservoir water quality, posing a threat to both the safety of drinking water and the quality of aquatic products sourced from these environments. However, few studies have explored how enhanced thermal stratification affects the occurrence and regulation of odorants in large drinking water reservoirs. Through systematic monitoring and investigation of Xin'anjiang Reservoir, we found that enhanced thermal stratification promotes filamentous cyanobacteria, particularly Leptolyngbya sp.

A Transformer-Based microvascular invasion classifier enhances prognostic stratification in HCC following radiofrequency ablation.

Background & Aims: We aimed to develop a Transformer-based deep learning (DL) network for prognostic stratification in hepatocellular carcinoma (HCC) patients undergoing RFA.

Methods: A Swin Transformer DL network was trained to establish associations between magnetic resonance imaging (MRI) datasets and the ground truth of microvascular invasion (MVI) based on 696 surgical resection (SR) patients with solitary HCC ≤3 cm, and was validated in an external cohort (n = 180). The multiphase MRI-based DL risk outputs using an optimal threshold of .

Thermocline stratification favors phytoplankton spatial overlap and species diversity in a subtropical deep reservoir.

Spatial segregation of species along opposing resource gradients is a major research topic in ecology as it enables the coexistence and maintenance of high diversity. Thermocline stratification causes heterogeneous resource distribution, however, the effect of thermocline stratification on phytoplankton dynamic in-depth profiles is still unclear. To understand the underlying mechanism behind the effects of thermocline stratification on phytoplankton species diversity in stratified lakes, the monthly changes in thermocline parameters, deep chlorophyll maxima (DCM) parameters, spatial overlap (SO) among major phytoplankton taxonomic groups, and phytoplankton species diversity were evaluated in Lake Qiandaohu in the Zhejiang Province of China from April 2017 to December 2018.

Predictable shifts in diversity and ecosystem function in phytoplankton and zooplankton communities along thermocline stratification intensity continua.

Thermocline stratification is a global threat to water quality in drinking water reservoirs, though its underlying mechanisms are not clear. The impacts of thermocline stratification intensity on biodiversity-ecosystem relationships were assessed using phytoplankton and zooplankton indicators from four stages of stratification in Lake Qiandaohu. There were significant differences in biomass, species diversity, and resource use efficiency (RUEpp = phytoplankton biomass/total phosphorus) for phytoplankton between continuous stratification and mixing periods, but only in FDis and RaoQ diversity indices for zooplankton.

The Effect and Mechanism of POSTN and Its Alternative Splicing on the Apoptosis of Myocardial Cells in Acute Myocardial Infarction: A Study in Vitro.

Our study aimed to investigate key molecular targets in the pathogenesis of AMI, and provide new strategy for the treatment. In this work, the myocardial ischemia and hypoxia model was constructed by using HL-1 mouse cardiomyocytes. The over-expressing POSTN wild-type, mutant and negative control lentiviruses (GV492-POSTNWT,GV492-POSTN-MUT, GV492-NC) was conducted and transfected.

Effects of reasoning demands triggered by genre on Chinese EFL learners' writing performance.

Introduction: Genres, having distinct communicative functions, elicit different levels of reasoning demands in writing tasks. The current study investigated the influence of cognitive complexity triggered by a seldom studied pair of genres (expository writing vs. argumentative writing) on Chinese advanced EFL learners' writing performance.

Sentiment annotations for 3827 simplified Chinese characters.

Sentiment analysis in Chinese natural language processing has been largely based on words annotated with sentiment categories or scores. Characters, however, are the basic orthographic, phonological, and in most cases, semantic units in the Chinese language. This study collected sentiment annotations for 3827 characters.

Research progress of nano selenium in the treatment of oxidative stress injury during hepatic ischemia-reperfusion injury.

Hepatic ischemia-reperfusion injury (HIRI) is an additional injury to ischemic tissue after hepatic revascularization, and its pathological mechanism is complex. HIRI is not only involved in the molecular targets that mediate cell death, such as ion channel activation, abnormal protease activation and mitochondrial dysfunction, but also related to the down-regulation of endogenous protective signals. As a by-product of normal aerobic metabolism, reactive oxygen species (ROS) act as a multi effect physiological signal factor at low concentration.

Candidate genes and their alternative splicing may be potential biomarkers of acute myocardial infarction: a study of mouse model.

Background: Acute myocardial infarction (AMI) is one of the leading causes of death in human being, and an effective diagnostic biomarker is still lacking. Whilst some gene association with AMI has been identified by RNA sequencing (RNA-seq), the relationship between alternative splicing and AMI is not clear.

Methods: We retrieved myocardial tissues within 24 h from mice with induced AMI and sham, and analysed the differentially expressed genes (DEGs) and differential alternative splicing genes (DASGs) by RNA-seq.