Metabolic network as an objective biomarker in monitoring deep brain stimulation for Parkinson's disease: a longitudinal study.

Background: With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson's disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with F-fluorodeoxyglucose in monitoring the STN DBS treatment for PD.

Methods: Age-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent F-FDG PET scans.

Correlations between dopaminergic dysfunction and abnormal metabolic network activity in REM sleep behavior disorder.

Striatal dopamine transporter (DAT) deficiency and abnormal expression of Parkinson's disease (PD)-related pattern (PDRP) have been observed in patients with idiopathic REM sleep behavior disorder (IRBD). This study aimed to investigate the correlations between these two measures with comparison to PD using a dual tracer imaging design. Age-matched 37 IRBD patients, 86 PD patients, and 15 control subjects underwent concurrent PET scans with C-CFT to quantify dopaminergic dysfunction and F-FDG to quantify PDRP expression.

Study of the Influence of Age in F-FDG PET Images Using a Data-Driven Approach and Its Evaluation in Alzheimer's Disease.

Objectives: F-FDG PET scan is one of the most frequently used neural imaging scans. However, the influence of age has proven to be the greatest interfering factor for many clinical dementia diagnoses when analyzing F-FDG PET images, since radiologists encounter difficulties when deciding whether the abnormalities in specific regions correlate with normal aging, disease, or both. In the present paper, the authors aimed to define specific brain regions and determine an age-correction mathematical model.

A novel individual-level morphological brain networks constructing method and its evaluation in PET and MR images.

Mapping the human brain is one of the great scientific challenges of the 21st century. Brain network analysis is an effective technique based on graph theory that is widely used to investigate network patterns in the human brain. Currently, mapping an individual brain network using a single image has been a hotspot in the field of brain science; techniques, such as the Kullback-Leibler (KL) method, have applications in structural Magnetic Resonance (MR) imaging.

Differences in Aβ brain networks in Alzheimer's disease and healthy controls.

The prevailing β-amyloid (Aβ)-cascade hypothesis is the most classical Alzheimer's disease (AD) pathogenesis. In this hypothesis, excessive Aβ plaque deposition in human brain is considered to be the cause of AD. Carbon 11-labeled Pittsburgh compound B Positron emission tomography (11C-PiB PET) is the latest technology to detect Aβ plaques in vivo.

18F-FDG imaging of a rare cutaneous infection by Mycobacterium avium complex.

A 17-year-old male patient was admitted into our hospital with granulomatous eruption (primarily on the lower extremities), diarrhea, fever, and weight loss for 6 months. F-FDG PET/CT scan was performed to rule out the possibility of malignant metastasis or paraneoplastic syndromes. F-FDG PET/CT scan showed multiple bone and skin lesions with significantly intense FDG uptakes and lymph nodes with moderate FDG uptake.

A method of semi-quantifying β-AP in brain PET-CT 11C-PiB images.

Alzheimer's disease (AD) is a common health problem for elderly populations. Positron emission tomography-computed tomography (PET-CT)11C-PiB for beta-P (amyloid-β peptide, β-AP) imaging is an advanced method to diagnose AD in early stage. However, in practice radiologists lack a standardized value to semi-quantify β-AP.

Differences in the metabolic status of healthy adults with and without active brown adipose tissue.

Background: Previous studies have proven the existence of active brown adipose tissue (BAT) in adults; however, its effect on systematic metabolism remains unclear.

Aim: The current study was designed to investigate the differences in the metabolic profiles of healthy adults with and without active BAT using positron emission tomography-computed tomography (PET-CT) scans in the un-stimulated state.

Methods: A cross-sectional analysis was performed to assess the health of adults using PET-CT whole-body scans at Huashan Hospital Medical Centre between November 2009 and May 2010.

[Influence of visual and auditory masking on the brain glucose metabolism in an idiopathic tinnitus patient].

Objective: To study the influence of the audio-visual block (AB) on the brain glucose metabolism of idiopathic tinnitus patients.

Methods: The brain positron emission tomography (PET) test was performed on one chronic idiopathic tinnitus patient under audio-visual block and non-block (NB) conditions respectively. The visual analysis and statistical parameter mapping (SPM) analysis were both used to detect the brain glucose metabolism difference under AB and NB conditions.

Efficacy of conventional whole-body ¹⁸F-FDG PET/CT in the incidental findings of parotid masses.

Objective: The objective of this study was to evaluate the incidence of incidental parotid masses with conventional whole-body ¹⁸F-deoxyglucose (FDG) PET/CT and assess the ability of PET/CT to characterize these unexpected parotid lesions.

Methods: Fifty eight incidental findings of parotid masses with routine FDG PET/CT whole-body scan were reviewed in this retrospective analysis, which were selected from the patients without any known or suspected parotid disease in our PET center, from June 2005 to May 2009. 51 cases were operated or underwent a biopsy after a short-term PET/CT study; the remaining 7 cases had a follow-up.

Granulomatous slack skin: assessment of disease progression and treatment response using positron emission tomography/computed tomography.

Granulomatous slack skin (GSS) is an extremely rare subtype of cutaneous T-cell lymphoma. A 14-year-old boy had suffered from progressive infiltrative erythema and plaques that gradually evolved into lax masses and pendulous skin on his axilla, anterior wall of the abdomen, bilateral inguinal region, and thighs. Histopathologic examination of the skin lesion and inguinal lymph node demonstrated granulomatous infiltration with multinucleated giant cells.

Non-Hodgkin's lymphoma of supraclavicular lymph nodes can mimic metastasis of breast cancer during chemotherapy on FDG PET/CT.

A 43-year-old woman who had a history of right mastectomy for breast cancer presented with fever and swelling in the right supraclavicular region during her second course of chemotherapy. An FDG PET/CT was performed to evaluate this patient, which revealed mildly increased FDG activity in the lymph node in the supraclavicular region. A metastatic lesion from the known breast cancer was considered.

Modulation of metabolic brain function by bilateral subthalamic nucleus stimulation in the treatment of Parkinson's disease.

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) was proposed as an effective way to improve the symptoms of Parkinson's disease (PD). We studied metabolic modulation in the brain by bilateral STN stimulation using FDG PET. Five PD patients (age 61.

Misdiagnoses of 11C-choline combined with 18F-FDG PET imaging in brain tumours.

Background And Objective: The widely applied F-FDG is known for its disadvantage in brain tumour PET imaging because of its high background uptake. C-choline can achieve high contrast of brain tumour imaging and was expected to have higher sensitivity and specificity. We analysed the misdiagnoses in C-choline PET imaging in brain tumours with the aim of improving the accuracy of diagnosis with C-choline PET imaging.