Publications by authors named "Zhemal Z Rakhmanova"
Post-transplant сyclophosphamide after matched donor hematopoietic stem cell transplantation in children with acute leukemia.
Anastasya Svyatoslavovna Borovkova Olesya Vladimirovna Paina Elena Vladimirovna Semenova Tatiana Alexandrovna Bykova Anna Alekseevna Osipova Zhemal Zarifovna Rakhmanova
Clin Transplant
January 2024
Article Synopsis
- - The study investigates the effectiveness of post-transplant cyclophosphamide (PTCy) in preventing graft-versus-host disease (GVHD) in pediatric acute leukemia patients who underwent matched allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- - A retrospective analysis of 190 children shows that PTCy-based GVHD prophylaxis led to significantly lower rates of acute and chronic GVHD after transplants from matched unrelated donors (MUD) compared to standard treatments.
- - The findings suggest PTCy is a promising and effective option for GVHD prevention in pediatric patients, particularly in MUD settings, while showing similar efficacy to traditional methods in matched sibling donor (MSD) transplants. *
Transplant-associated thrombotic microangiopathy (TA-TMA) is a specific complication of allogeneic hematopoietic cell transplantation with a multifactorial etiology. There is little evidence published regarding the efficacy and factors influencing the outcome of substitution of calcineurin inhibitors (CNIs) with other agentsas a widely accepted practice in this disorder; however, there are limited data on the options for immunosuppression manipulation (ISM). In our study, we retrospectively analyzed outcomes of 45 patients with TA-TMA with ISM and substitution either with steroids (steroid group) or anmTOR inhibitor sirolimus (sirolimus group).
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