Comparative Study on the Efficacy and Safety of Emergency Surgery Versus Endoscopic Stent Placement Followed by Definitive Surgery in the Treatment of Colorectal Obstruction.

Aim: Tumor-induced acute intestinal obstruction is a severe complication that poses significant threats to patient life. Emergency surgery is a widely used treatment method, but this approach has certain limitations such as high mortality and complication rates. Developments in endoscopic and minimally invasive techniques have provoked interest in postoperative definitive resection or conservative treatment following colorectal stent placement.

Prognostic value and potential regulatory relationship of miR-200c-5p in colorectal cancer.

This study aimed to investigate the relationship and potential mechanisms of miR-200c-5p in colorectal cancer (CRC) progression. Differentially expressed miRNAs were screened using the TCGA database. Subsequently, univariate analysis was performed to identify CRC survival-related miRNAs.

Phase II study of anlotinib in combination with oxaliplatin and capecitabine for patients with RAS/BRAF wild-type metastatic colorectal adenocarcinoma as the first-line therapy.

Background: Anlotinib, an oral small molecule tyrosine kinase inhibitor targeting VEGFR 1/2/3, FGFR 1-4, PDGFR a/β, and c-kit, had demonstrated prolonged progression-free survival (PFS) in refractory metastatic colorectal cancer (mCRC). This multicenter, single-arm, phase II, exploratory study was conducted to evaluate the efficacy and safety of anlotinib combined with capecitabine and oxaliplatin as first-line treatment for unresectable RAS/BRAF wild-type mCRC.

Methods: Patients aged 18-75 with RAS/BRAF wild-type unresectable mCRC, without prior systemic treatment, and ECOG performance status ≤1 were enrolled.