Publications by authors named "Zheina Cherneva"
Chronic obstructive pulmonary disease (COPD) augments the likelihood of having left ventricular diastolic dysfunction (LVDD)-precursor of heart failure with preserved ejection fraction (HFpEF). LVDD shares overlapping symptomatology (cough and dyspnea) with COPD. Stress induced LVDD is indicative of masked HFpEF.
View Article and Find Full Text PDFObjectives: Autonomic dysfunction (AD) and dynamic hyperinflation (DH) have been implicated as pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) in chronic obstructive pulmonary disease COPD) patients. Their association, however, remains elusive: The aims of the study were: (1) to determine the prevalence of AD and DH in non-severe COPD patients, with exertional dyspnea, without clinically overt cardio-vascular (CV) comorbidities; (2) to analyze the correlation and clinical significance between DH, AD, and maksed HFpEF.
Methods: We applied CPET in 68 subjects.
Stress echocardiography for left ventricular diastolic dysfunction detection in patients with non-severe chronic obstructive pulmonary disease: a cross-sectional study.
Croat Med J
October 2019
Article Synopsis
- The study aimed to determine if combining exercise stress echocardiography and cardio-pulmonary testing can help diagnose early left ventricular diastolic dysfunction (LVDD) in patients with mild chronic obstructive pulmonary disease (COPD) and exercise-related breathing difficulties.
- Conducted with 104 non-severe COPD patients, the research found that 64% exhibited stress-induced LVDD during testing, characterized by lower exercise capacity and efficiency.
- The results suggest that the combined testing can identify hidden LVDD in these patients, but the cardio-pulmonary testing measures did not predict the presence of LVDD.
Background: Oxidative stress and inflammation are assumed as the main pathological triggers for vascular damage in hypersomnolent obstructive sleep apnoea (OSA) patients, whereas their exact role in less symptomatic population is currently unknown.
Aim: To determine whether oxidative stress (urinary 8-isoprostane concentration) and inflammation (plasma resistin levels) are associated with vascular damage in non-hypersomnolent (Epworth Sleep Score <11) OSA patients.
Methods: A total of 325 consecutive patients have undergone standard polysomnography, and 256 of them were diagnosed with OSA.