Centrifuge model test studies on mechanically-biologically treated waste under seismic loading.

Early earthquakes often trigger landfill slope failures and damage to cover and liner systems, resulting in gas leakage, environmental contamination, and significant risks to landfill safety. Accurately assessing the static and dynamic characteristics of mechanically biologically treated (MBT) waste is crucial. Centrifuge shaking table tests offer a robust method to address the limitations of conventional shaking table tests by effectively simulating the static and dynamic stress-strain fields of prototype soils, fulfilling the requirements for comprehensive static and dynamic analysis.

A Validated Liquid Chromatography-Tandem Mass Spectrometry Assay for the Determination of NX-5948 in Beagle Dog Plasma: Application to a Pharmacokinetic Study.

Proteolysis targeting chimera (PROTAC) has been developed and currently enjoys widespread interest among the field of pharmaceutical manufacturing in recent decades. NX-5948 is an orally active PROTAC Bruton tyrosine kinase degrader, which shows anti-inflammatory and antitumor activities. In this study, a simple and fast bioanalytical method for the quantification of NX-5948 in beagle dog plasma was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS).