Publications by authors named "Zhefeng Cai"
Background: During the spread of the novel coronavirus disease (COVID-19), internet hospitals in China were engaged with epidemic prevention and control, offering epidemic-related online services and medical support to the public.
Objective: The aim of this study is to explore the role of internet hospitals during the prevention and control of the COVID-19 outbreak in China.
Methods: Online epidemic-related consultations from multicenter internet hospitals in China during the COVID-19 epidemic were collected.
Article Synopsis
- Low yields and significant epimerization in peptide-α-thioesters hinder the effectiveness of native chemical ligation (NCL), while more reactive peptide arylthioesters are difficult to manage due to hydrolysis.
- A new photochemical method using 7-nitroindoline is introduced, enabling high yield generation of protected peptide phenylthioesters from photoreactive precursors under neutral conditions and with minimal epimerization.
- This approach is compatible with Fmoc-strategy solid-phase synthesis and allows for global deprotection to obtain peptide phenylthioesters, and can also convert peptide precursors into hydrazides.
Aim: To synthesize and study the anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoromethanesulfonyloxy-phenyl)-ethoxy]-phenyl}-propionic acid (compound I).
Methods: Compound I was prepared in 6 steps, using 4-(2-hydroxy-ethyl)-phenol as the starting material. The in vitro selectivity and potency of target compound I, rosiglitazone and WY-14643 on human PPARalpha and PPARgamma were determined in reporter gene assays.
A series of azaindole-alpha-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure-activity relationship was developed for PPARalpha/gamma dual agonism. One of the synthesized compound 7a was identified as a potent, selective PPARalpha/gamma dual agonist.
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