Publications by authors named "Zhedong Wan"
Giant unruptured sinus of Valsalva aneurysms causing angina pectoris.
J Cardiothorac Surg
April 2024
Article Synopsis
- Sinus of Valsalva aneurysm (SVA) is a rare heart problem that can either be born with or develop later, and it often doesn’t show symptoms unless it’s causing other issues.
- A 64-year-old woman had trouble breathing and chest pain for three months, and tests showed she had two unruptured SVAs that were putting pressure on her heart.
- The woman had surgery to fix her heart, which helped her symptoms, showing that doctors should think about SVA when patients have chest pain.
Cardiac angiosarcoma: A case report and review of current treatment.
Medicine (Baltimore)
December 2019
Rationale: Primary cardiac angiosarcoma is a rare malignant cardiac neoplasm with early metastasis and poor prognosis. As there are currently no guidelines or effective therapeutic strategies, management of this condition depends on previous experiences of the clinician treating and the consideration of reported cases.
Patient Concerns: A 65-year-old male presented to our department with a 4-day history of chest tightness, dyspnea, lower extremity weakness and occasional dizziness, and a transthoracic echo (TTE) revealed a right atrium occupying mass.
Objective: This study is intended to figure out the function of microRNA-218 (miR-218) together with microphthalmia-associated transcription factor (MITF) on the cardiac fibrosis and cardiac function impairment in rat models of myocardial infarction (MI).
Results: The rats with MI exhibited cardiac function impairment, cardiac fibrosis, oxidative stress, cardiomyocyte apoptosis, as well as inflammatory injury. Additionally, upregulated miR-218 and downregulated MITF were detected in cardiac tissues of MI rats.