Publications by authors named "Zhean Zhan"
Article Synopsis
- This study investigated how N-methyl-D-aspartate receptors (NMDARs) affect bladder smooth muscle (BSM) and their potential role in treating overactive bladder conditions.
- Various methods, including myography and RNA sequencing, were used to assess NMDAR activity and their expression in BSM cells.
- Results showed that there are no functional NMDARs in BSM, suggesting that the benefits of NMDAR inhibition for treating overactive bladder may not directly involve BSM, indicating a need to investigate other therapeutic targets.
Establishment of new transurethral catheterization methods for male mice.
Biol Methods Protoc
February 2024
Transurethral catheterization in mice is multifaceted, serving essential functions such as perfusion and drug delivery, and is critical in the development of various urological animal disease models. The complex anatomy of the male mouse urethra presents significant challenges in transurethral catheterization, leading to a predominance of research focused on female specimens. This bias limits the utilization of male mice in lower urinary tract disease studies.
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