Publications by authors named "Zhe-Zhong Zhang"
J Inflamm Res
September 2024
Article Synopsis
- This study investigates the role and importance of CALU in various cancers, primarily focusing on its impact on tumor progression and treatment resistance, especially in breast cancer.
- Researchers analyzed CALU expression and its link to patient outcomes across multiple cancer types, utilizing various databases and experimental methods.
- Findings showed that higher CALU levels are associated with worse prognoses, driven by genomic changes, and CALU plays a significant role in promoting epithelial-mesenchymal transition (EMT) in both cancer cells and cancer-associated fibroblasts (CAFs).
Article Synopsis
- Recurrent pregnancy loss (RPL) is a complex issue with various causes, and roughly half of the cases remain unexplained; this study explores the role of iron metabolism genes in RPL.
- Researchers analyzed gene expression data to identify key hub genes, specifically CISD2 and CYP17A1, linked to iron metabolism—both were found to have reduced expression in RPL samples.
- The findings indicate that these genes could serve as potential diagnostic markers for RPL, with implications for understanding immune interactions and cellular processes involved in the condition.
