Publications by authors named "Zhe-Zhe Wang"
Article Synopsis
- Neuropathic pain is a prevalent issue affecting many people, with limited effective treatment options; this study investigates the potential role of microtubule affinity-regulating kinases (MARK1 and MARK2) in this type of pain.
- Researchers used a rat model of neuropathic pain and employed genetic knockdown of MARKs and a small molecule inhibitor to assess their influence on pain, cognitive function, and anxiety.
- The findings revealed that inhibiting MARKs can reduce pain-like behaviors and improve cognitive and motor deficits, suggesting that targeting MARKs may offer a new approach for treating neuropathic pain.
Background And Purpose: Indoleamine 2, 3-dioxygenase 1 (IDO1) has been linked to neuropathic pain and IDO1 inhibitors have been shown to reduce pain in animals. Some studies have indicated that IDO1 expression increased after neuropathic pain in hippocampus and spinal cord, whether these changes existing in anterior cingulate cortex (ACC) and amygdala remains obscure and how IDO1 inhibition leads to analgesia is largely unknown. Here, we evaluated the antinociceptive effect of PCC0208009, an indirect IDO1 inhibitor, on neuropathic pain and examined the related neurobiological mechanisms.
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