Publications by authors named "Zhe-Harn Anne Lin"
Chem Biol Interact
August 2018
Article Synopsis
- Imatinib is a key drug for treating chronic myeloid leukemia (CML), but some patients develop resistance due to mutations in the BCR-ABL domain, while others may not.
- Research found that higher levels of protective autophagy in IM-resistant K562 (K562R) cells contribute to this resistance, and inhibiting autophagy increased the effectiveness of Imatinib.
- MicroRNA (miR)-199a/b-5p was identified as a potential therapeutic target, as it reduces autophagy and increases cell death in K562R cells by inhibiting WNT2, a gene that regulates autophagy and influences drug sensitivity.
