Preoperative imaging biomarkers combined with tap test for predicting shunt surgery outcome in idiopathic normal pressure hydrocephalus: a multicenter retrospective study.

Objectives: The study aims to investigate the predictive performance of preoperative imaging features combined with tap test for the outcomes of ventriculoperitoneal (VP) shunt in idiopathic normal pressure hydrocephalus (iNPH).

Methods: In this multicenter retrospective study, 166 iNPH patients who underwent VP shunt surgery between August 2019 and November 2023 were included. Preoperative clinical characteristics and imaging features were collected.

Antifungal and controlled release properties of hymexazol-chitosan-graphene oxide composite.

Pesticide carrier systems possess various advantages such as prolonged storage, lowered toxicity, and reduced environmental pollution of pesticides. Controlled release of pesticides from carriers can enhance the durability of the pesticide effect, reduce the pesticide application frequency and environmental pollution, and promote sustainable agricultural development, which represents a significant direction for the advancement of modern agriculture. Chitosan-graphene oxide (GO-CS) has been demonstrated as a promising carrier of drugs, but its application in pesticide delivery in agriculture remains largely unexplored.

Mass Transport-Dependent C-C Bond Formation for CO Electroreduction with Alkali Cations.

Electrolyte cation identity has been reported to influence the multicarbon (C) selectivity in CO/CO electroreduction. However, most of the previous work for cation size effect is based on H-cell configurations, which may inadvertently distort the underlying mechanism of cation effect due to mass transport limitations, particularly for CO reduction. Here, using GDE-type flow electrolyzers, we report that the selectivity of total C products on Cu is independent of alkali cation identity (Li, Na, K, and Cs) in the absence of the CO transport limitation.

A low-dose protocol in pediatric F-FDG scans using 30-cm axis field of view PET/CT.

Objective: To explore the feasibility of a low-dose F-FDG protocol for the 30-cm standard axial field of view (SAFOV) PET/CT imaging in pediatric patients.

Methods: A retrospective analysis was conducted on 112 pediatric patients who underwent a full-dose (3.7 MBq/kg) F-FDG PET/CT imaging, and a prospective analysis was performed on 55 patients who received a low-dose (2.

One-Stop 68Ga-FAPI/18F-FDG Total-Body PET/CT Scan: More Theranostics Information Available.

Purpose: This prospective study aims to assess the feasibility of a one-stop imaging protocol using 68Ga-FAPI-04/18F-FDG dual-radiotracer with dual-low-activity for tumor imaging.

Patients And Methods: Forty patients underwent one-stop 68Ga-FAPI-04 PET (PETFAPI) and dual-radiotracer PET (PETDUAL) using a total-body PET/CT scanner with a 194-cm axial field of view. After a half-dose (0.

Eliminating the second CT scan of dual-tracer total-body PET/CT via deep learning-based image synthesis and registration.

Purpose: This study aims to develop and validate a deep learning framework designed to eliminate the second CT scan of dual-tracer total-body PET/CT imaging.

Methods: We retrospectively included three cohorts of 247 patients who underwent dual-tracer total-body PET/CT imaging on two separate days (time interval:1-11 days). Out of these, 167 underwent [Ga]Ga-DOTATATE/[F]FDG, 50 underwent [Ga]Ga-PSMA-11/[F]FDG, and 30 underwent [Ga]Ga-FAPI-04/[F]FDG.

The modified heart team protocol facilitated the revascularization decision-making quality in complex coronary artery disease.

Objectives: A lack of standardization in heart team implementation potentially leads to suboptimal decision-making quality, and we previously established a modified heart team protocol to improve the decision-making quality. The present trial was to validate the effect of the modified heart team implementation protocol on improving the decision-making quality versus the conventional protocol in complex coronary artery disease (CAD).

Methods: Eligible interventional cardiologists, cardiac surgeons and non-interventional cardiologists were randomly allocated to the intervention or control arm and established 12 heart teams in each arm.

Additive predictive value of left ventricular end-diastolic volume index to the development of persistent atrial fibrillation in non-obstructive hypertrophic cardiomyopathy.

Objective To evaluate the association between left ventricular diastolic volume index (LVEDVi) and the risk of persistent or long-standing persistent atrial fibrillation (perAF) in non-obstructive hypertrophic cardiomyopathy (NOHCM) patients. Methods Forty-nigh NOHCM patients with perAF were selected as the case group (NOHCMAF group). A control group comprised 98 NOHCM patients without atrial fibrillation (AF) history.

Ictal scalp EEG patterns are shaped by seizure etiology in temporal lobe epilepsy.

Objective: To investigate how etiology and seizure localization influence ictal scalp electroencephalographic (EEG) patterns in temporal lobe epilepsy (TLE).

Methods: We retrospectively analyzed ictal EEG features from 504 focal seizures recorded in 189 TLE patients with various etiologies who underwent resective surgery.

Results: For seizure onset patterns (SOPs), α/β onset was more common in the low-grade tumor group (38.

Rational design of AIEgens through π-bridge engineering for dual-modal photodynamic and photothermal therapy.

A series of aggregation-induced emission luminogens (AIEgens) with donor-π-acceptor (D-π-A) architecture were rationally designed and synthesized through π-bridge engineering for dual-modal photodynamic and photothermal therapy. The AIEgens (TPT, TFT, and TTT) were constructed using methoxy-substituted tetraphenylene as the electron donor and tricyanofuran as the electron acceptor, connected via different π-bridges (phenyl, furan, or thiophene). These compounds exhibited red-shifted absorption (460-545 nm) and emission (712-720 nm) with remarkable aggregation-induced emission characteristics.

Identification of long non-coding RNAs and their multiple regulation mechanism in shell deposition of pearl oyster.

Biomineralization to fabricate diverse morphology shell is typical character of bivalve species and ectopic calcification to form is the production of defense. Long non-coding RNAs (LncRNAs) plays critical roles in multiple cellular biological processes in invertebrate and vertebrate. However, LncRNAs remain poorly understood about expression and regulation roles in bivalve biomineralization studies.

Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study.

Background: Remnant cholesterol (remnant-C) contributes to atherosclerotic cardiovascular disease (ASCVD), particularly in individuals with impaired glucose metabolism. Patients with impaired glucose metabolism and ASCVD remain at significant residual risk after coronary artery bypass grafting (CABG). However, the role of remnant-C in this population has not yet been investigated.

TDO2 + cancer-associated fibroblasts mediate cutaneous squamous cell carcinoma immune escape via impeding infiltration of CD8 + T cells.

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, originating from the malignant proliferation of squamous epithelial cells. However, its pathogenesis remains unclear. To further explore the mechanisms underlying cSCC, we analyzed the data from one single-cell RNA sequencing study and discovered a significant upregulation of tryptophan 2,3-dioxygenase (TDO2) in the cancer-associated fibroblasts (CAFs).

[F]FDG PET/CT for predicting neoadjuvant PD-L1 blockade monotherapy treatment response in patients with locally advanced esophageal squamous cell carcinoma: a preliminary study.

Purpose: To investigate the predictive value of 2-[18F]-fluoro-2-deoxy-D-glucose ([F]FDG) PET/CT for evaluating primary tumor (PT) and lymph node (LN) responses after neoadjuvant programmed death-ligand 1 (PD-L1) blockade monotherapy in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC).

Methods: In the single-arm phase 1b NATION-1907 trial (NCT04215471), 23 patients with LA-ESCC received two cycles of neoadjuvant PD-L1 blockade Adebrelimab followed by surgery. Among these, 18 patients underwent [F]FDG PET/CT scans both before immunotherapy and prior to surgery.

Eco-friendly and facile one-step synthesis of manganese perovskite (TMPEA)MnBr for high performance X-ray imaging.

Inorganic-organic metal halogen perovskites, especially eco-friendly perovskites, have been intensively developed for X-ray imaging due to the high sensitivity, the low detection limit, and the high light yield. In this work, we successfully synthesized eco-friendly perovskite trimethylphenylammonium manganese(ii) bromide ((TMPEA)MnBr) with a facile one-step method at room temperature and demonstrated its impressive potential for X-ray imaging. As-synthesized (TMPEA)MnBr films have exhibited a high photoluminescence quantum yield (PLQY) of 83.

New chapter in reform and development of organ donation and transplantation in China: Embracing past, grounding in national conditions, upholding steadfast belief, and looking forward to future.

The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization (WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community.

Cold shock proteins CIRBP and RBM3 may indicate hypothermia death: A case report.

Cold-inducible RNA-binding protein (CIRBP) and RNA binding motif protein 3 (RBM3) are both members of the cold shock protein family expressed in response to low-temperature induction. However, their usefulness in the diagnosis of fatal hypothermia in forensic has not been reported. In this study, we report the case of a female who died of fatal hypothermia.

Leveraging Real-World Evidence to Define Severe RSV Lower Respiratory Tract Disease in Adults.

Introduction: As no standard case definitions for respiratory syncytial virus-associated lower respiratory tract disease (RSV-LRTD) in adults are available, this study analyzed definitions for severe RSV-LRTD from previously published data in hospital and community cohorts of adults with RSV-associated symptoms.

Methods: The frequency, sensitivity, and specificity of acute respiratory disease symptoms among hospitalized and community cohorts of adults with RSV were analyzed. RSV-LRTD signs/symptoms assessed included shortness of breath (dyspnea), cough and/or fever, wheezing/rales/rhonchi (abnormal lung sounds by auscultation), sputum production, tachypnea, hypoxemia, and pleuritic chest pain.