Research on Upper Limb Motion Intention Classification and Rehabilitation Robot Control Based on sEMG.

sEMG is a non-invasive biomedical engineering technique that can detect and record electrical signals generated by muscles, reflecting both motor intentions and the degree of muscle contraction. This study aims to classify and recognize nine types of upper limb motor intentions based on surface electromyography (sEMG) and apply them to the interactive control of an end-effector rehabilitation robot. The research begins with selecting muscles and data preprocessing, incorporating the generation mechanism of sEMG along with the anatomical and kinesiological principles of upper limb muscles.

The tomato gene Ty-6, encoding DNA polymerase delta subunit 1, confers broad resistance to Geminiviruses.

The tomato Ty-6 gene conferring resistance against begomoviruses has been cloned and shown to be a variant of DNA polymerase delta subunit 1. Ty-6 is a major resistance gene of tomato that provides resistance against monopartite and bipartite begomoviruses. The locus was previously mapped on chromosome 10, and in this study, we fine-mapped Ty-6 to a region of 47 kb, including four annotated candidate genes.

Trends and the Role of Gene-Environment Interactions in Idiopathic Membranous Nephropathy in Northern China.

Introduction: Idiopathic membranous nephropathy (iMN) has become one of the most prevalent primary glomerular diseases, with a marked increase in prevalence over the past two decades in northern China. Fine particulate matter (PM2.5) is considered to be associated with this rising prevalence.

Expression and significance of cystine transporter SLC7A11/xCT in early colorectal cancer specimens from endoscopic submucosal dissection.

The SLC7A11/xCT cystine transporter is intricately linked with ferroptosis. By mediating intracellular cystine flux, it regulates oxidative stress within neoplastic cells, thereby curtailing ferroptosis and influencing the emergence of colorectal cancer. This study aimed to gauge the SLC7A11/xCT expression across various tumorigenic stages in early colorectal adenocarcinoma tissues, shedding light on its specific role in the genesis of these early malignancies.

Bibliometric analysis of T-cells immunity in pulmonary hypertension from 1992 to 2022.

Background: Adaptive immunity is an important disease mediator of pulmonary vascular remodeling during pulmonary hypertension (PH) development, especially T-cells lymphocytes. However, data for bibliometric analysis of T cell immunity in PH is currently vacant. This aimed to provide a comprehensive and visualized view of T-cells research in PH pathogenesis and to lay a solid foundation for further studies.

Behind the Non-Uniform Breakup of Bubble Slug in Y-Shaped Microchannel: Dynamics and Mechanisms.

Bubble flow in confined geometries is a problem of fundamental and technological significance. Among all the forms, bubble breakup in bifurcated microchannels is one of the most commonly encountered scenarios, where an in-depth understanding is necessary for better leveraging the process. This study numerically investigates the non-uniform breakup of a bubble slug in Y-shaped microchannels under different flow ratios, Reynolds numbers, and initial bubble volumes.

Higher prevalence of thyroid-specific autoantibodies (TPOAb and TgAb) is related to a higher prevalence of fractures in females: results from NHANES 2007-2010.

Unlabelled: A retrospective analysis was conducted using data from the NHANES. Bone mineral density (BMD) was compared in different thyroid-specific autoantibodies groups. Strengths of associations were calculated by using binary logistic regression models.

Bibliometric analysis of mucosal immunity in IgA nephropathy from 1990 to 2022.

Objective: The study aimed to conduct a bibliometric analysis of mucosal immunity in IgA nephropathy (IgAN) and indicate its current status, hot sopts, and direction of future studies.

Methods: The literature data was collected from the Web of Science Core Collection. CiteSpace 6.

Metabolomic and physiological analysis of alfalfa (Medicago sativa L.) in response to saline and alkaline stress.

Alfalfa (Medicago sativa L.) is a leguminous forage widely grown worldwide. Saline and alkaline stress can affect its development and yield.

Research on the variation law of floor stress information entropy in upper protective layer mining based on Brillouin optical fiber sensing.

The characteristics of floor failure and stress changes during the mining process of protective layers are crucial for determining the effectiveness of pressure relief. Three boreholes were designed in the 21104 fully mechanized mining face of Hulusu Coal Mine to implant optical fibers into the floor of the working face. A fiber optic monitoring system was established to monitor the dynamic evolution of stress in the floor rock mass at different mining distances.

Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.

Diabetic kidney disease is a common complication of diabetes and remains the primary cause of end-stage kidney disease in the general population. Schisandrin B (Sch B) is an active ingredient in Schisandra chinensis. Our study illustrates that Sch B can mitigate renal tubular cell (RTC) epithelial-mesenchymal transition (EMT) and mitochondrial dysfunction in db/db mice, accompanied by the downregulation of TGF-β1 and the upregulation of PGC-1α.

Design of a Self-Aligning Four-Finger Exoskeleton for Finger Abduction/Adduction and Flexion/Extension Motion.

For wearable four-finger exoskeletons, it is still a challenge to design the metacarpophalangeal (MCP)joint abduction/adduction (a/a) kinematic chain and achieve axes self-aligning. This paper proposes a novel exoskeleton for four fingers that features a high degree of dexterity enabling MCP joint flexion/extension (f/e) and a/a motion. Other features of the exoskeleton include a self-aligning mechanism that absorbs misalignment between the exoskeleton and human joints, the ability to accommodate fingers of different sizes, and a compact design that allows simultaneous a/a motion without interference.

Pituitary Apoplexy-associated Cerebral Salt Wasting Syndrome: A Case Report and Literature Review.

Purpose: This is a case report of a patient experiencing hyponatremia who was ultimately diagnosed with pituitary apoplexy-associated cerebral salt wasting syndrome (CSWS).

Methods: Laboratory tests, clinical evaluations, and magnetic resonance imaging were performed by specialists.

Findings: The patient presented with severe headache, thirst, and polyuria.

Recent Advances in Flexible Wearable Supercapacitors: Properties, Fabrication, and Applications.

A supercapacitor is a potential electrochemical energy storage device with high-power density (PD) for driving flexible, smart, electronic devices. In particular, flexible supercapacitors (FSCs) have reliable mechanical and electrochemical properties and have become an important part of wearable, smart, electronic devices. It is noteworthy that the flexible electrode, electrolyte, separator and current collector all play key roles in overall FSCs.

Corrigendum to "Fluoxetine combined with risperidone in treatment of online gambling disorder-case report" [Heliyon 9 (3) (March 2023) Article e13772].

[This corrects the article DOI: 10.1016/j.heliyon.

Extracellular vesicle-mediated intercellular and interorgan crosstalk of pancreatic islet in health and diabetes.

Diabetes mellitus (DM) is a systemic metabolic disease with high mortality and morbidity. Extracellular vesicles (EVs) have emerged as a novel class of signaling molecules, biomarkers and therapeutic agents. EVs-mediated intercellular and interorgan crosstalk of pancreatic islets plays a crucial role in the regulation of insulin secretion of β-cells and insulin action in peripheral insulin target tissues, maintaining glucose homeostasis under physiological conditions, and it's also involved in pathological changes including autoimmune response, insulin resistance and β-cell failure associated with DM.

Combination of Rituximab and Low-dose Tacrolimus in the Treatment of Refractory Membranous Nephropathy: A Retrospective Cohort Study.

Background: Conventional regimens for refractory idiopathic membranous nephropathy (IMN) still have limitations. Rituximab (RTX) has a good effect in the treatment of refractory IMN. However, whether RTX single or combined with immunosuppressive therapy is more effective and whether adverse events will increase are still inconclusive.

Integrated single-nucleus and spatial transcriptomics captures transitional states in soybean nodule maturation.

Legumes form symbiosis with rhizobium leading to the development of nitrogen-fixing nodules. By integrating single-nucleus and spatial transcriptomics, we established a cell atlas of soybean nodules and roots. In central infected zones of nodules, we found that uninfected cells specialize into functionally distinct subgroups during nodule development, and revealed a transitional subtype of infected cells with enriched nodulation-related genes.

Fluoxetine combined with risperidone in treatment of online gambling disorder-case report.

Pathological gambling leaves seriously negative impacts on individuals, families, and society. With the universal use of internet, online gambling disorder is also increasing worldwide. However, there is currently a lack of effective treatments, especially medical treatments, for online gambling disorder.

The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis.

Background: Polycystic ovarian syndrome (PCOS) is one of the most common causes of infertility in reproductive-age women. However, the efficacy and optimal therapeutic strategy for reproductive outcomes are still under debate. We conducted a systematic review and network meta-analysis to compare the efficacy of different first-line pharmacological therapies in terms of reproductive outcomes for women with PCOS and infertility.

"It's your Liangxin that tells you what to do": Interpreting workplace-induced emotions in a Chinese nursing home.

How Direct Care Workers (DCWs) interpret their work and perform care activities undeniably impacts the well-being of institutionalized older adults. Despite the emotionally charged nature of paid care work, little is known about how Chinese DCWs talk about their work and construct meaning within China's unique social context of a burgeoning institutional care market and changing cultural expectations for long-term care. This study qualitatively explored Chinese DCWs' emotion work as they navigate among institutional pressures and low social recognition in an urban government-sponsored nursing home in central China.

Preliminary study on intravoxel incoherent motion imaging and diffusion kurtosis imaging based on magnetic resonance imaging of normal kidneys in children.

Background: Renal disease in children may lead to a continuous decline of renal function. Multimodal functional magnetic resonance imaging (fMRI) technology can provide quantitative evaluation of renal function information. We investigated the feasibility of intravoxel incoherent motion imaging (IVIM) and diffusion kurtosis imaging (DKI) based on 3.

Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease.

Diabetic kidney disease (DKD) is the main complication in diabetes mellitus (DM) and the main cause of end-stage kidney disease worldwide. However, sodium glucose cotransporter 2 (SGLT2) inhibition, glucagon-like peptide-1 (GLP-1) receptor agonist, mineralocorticoid receptor antagonists and endothelin receptor A inhibition have yielded promising effects in DKD, a great part of patients inevitably continue to progress to uremia. Newly effective therapeutic options are urgently needed to postpone DKD progression.