Advances in the application of neuroinflammatory molecular imaging in brain malignancies.

The prevalence of brain cancer has been increasing in recent decades, posing significant healthcare challenges. The introduction of immunotherapies has brought forth notable diagnostic imaging challenges for brain tumors. The tumor microenvironment undergoes substantial changes in induced immunosuppression and immune responses following the development of primary brain tumor and brain metastasis, affecting the progression and metastasis of brain tumors.

Influence of the Dynamically Disordered N-Terminal Tail Domain on the Amyloid Core Structure of Human Y145Stop Prion Protein Fibrils.

The Y145Stop mutant of human prion protein (huPrP23-144) is associated with a familial prionopathy and provides a convenient model for investigating amyloid strains and cross-seeding barriers. huPrP23-144 fibrils feature a compact and relatively rigid parallel in-register -sheet amyloid core spanning ∼30 C-terminal amino acid residues (∼112-141) and a large ∼90-residue dynamically disordered N-terminal tail domain. Here, we systematically evaluate the influence of this dynamic domain on the structure adopted by the huPrP23-144 amyloid core region, by investigating using magic-angle spinning solid-state nuclear magnetic resonance (NMR) spectroscopy a series of fibril samples formed by huPrP23-144 variants corresponding to deletions of large segments of the N-terminal tail.

Efficient method for the calculation of the optical force of multiple nanoparticles based on the coupling theory of quasinormal modes.

An efficient method is proposed for the calculation of the optical force of multiple nanoparticles. In this method, the optical force is calculated by integrating the Maxwell stress tensor (MST) over a closed surface encompassing the nanoparticle. The electromagnetic (EM) field required for evaluating the MST is computed with the coupling theory of quasinormal modes (QNMs), in which the EM field is expanded onto a small set of QNMs of each nanoparticle.

Efficient method for the calculation of the optical force of a single nanoparticle based on the quasinormal mode expansion.

An efficient method for the calculation of the optical force of a single nanoparticle is proposed based on the expansion of quasinormal modes (QNMs), which are eigensolutions of source-free Maxwell's equations with complex eigenfrequencies. In this method, the optical force is calculated by integrating the Maxwell stress tensor (MST) over a closed surface encompassing the nanoparticle. The electromagnetic (EM) field required for evaluating the MST is computed by a rigorous modal analysis, in which the EM field is expanded onto a small set of QNMs.

Probing Local Structure of Layered Double Hydroxides with (1)H Solid-State NMR Spectroscopy on Deuterated Samples.

By using a simple and efficient deuteration process, (2)H has been successfully introduced into layered double hydroxides (LDHs). Due to significantly less (1)H-(1)H homonuclear dipolar coupling, high-resolution (1)H solid-state NMR spectra can now be obtained conveniently at medium to low spinning speed to extract the information of cation ordering in LDHs. Furthermore, we show that double-resonance experiments can be applied easily to investigate internuclear proximities and test possible cation-ordered superstructure models.