Protective effects of cathelicidin-encoding Lactococcus lactis in murine ulcerative colitis.

Background And Aim: Intrarectal administration of mouse cathelin-related antimicrobial peptide (mCRAMP) reduced intestinal inflammation in mice. In the current study, we examined whether mCRAMP-transformed Lactococcus lactis given orally attained similar protective effects.

Method: mCRAMP was produced and secreted from the transformed L.