Aim: To analyze associations between homocysteine level, MTHFR and FTO rs1477196 polymorphisms and folate status in patients with breast cancer (BC) in order to clarify determinants of hyperhomocysteinemia.
Patients And Methods: The study included 315 BC cases and 604 controls.
Results: The MTHFRC677T genotype was associated with an increased incidence of BC [Odds ratio (OR)=1.