Modulation of cerebellar homotopic connectivity by modified electroconvulsive therapy at rest: Study of first-episode, drug-naive adolescent major depressive disorder.

Previous studies of brain function alterations that are associated with modified electroconvulsive therapy (MECT) for major depressive disorder (MDD) have yielded conflicting results because of variations in treatment durations, types of antidepressants, and disease course. Consequently, predicting the efficacy of MECT remains challenging. Thirty patients with first-episode, drug-naive adolescent MDD and 34 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging and neuropsychological tests.