Publications by authors named "Zhaoyu Guo"

Objectives: To estimate the global burden of malaria and neglected tropical diseases (NTDs) in children and adolescents aged 0-19 years and to analyse trends to inform public health and policy decisions.

Design: Population-based, cross-sectional study.

Setting: Global analysis across 204 countries and territories.

View Article and Find Full Text PDF

Trehalose has an important function for alleviating various abiotic stress in plants. Nevertheless, the functional and evolutionary characteristics of trehalose biosynthesis genes in mangrove plants is not documented. Here, using typical mangrove Avicennia marina, we found the trehalose content decreased in the roots and leaves and T6P increased significantly in the leaves under tidal submergence.

View Article and Find Full Text PDF

An autofluorescent inclusion (AFI) specifically accumulated in mesophyll cells (MCs) of non-salt-secretor mangrove was found to be related to salt, but its biosynthesis and spatial distribution characteristics remain unclear. Here, Kandelia obovata served as the experimental material, and the composition of AFI was identified as condensed tannin (CT). Na contents increased in purified AFIs under NaCl treatment, while Na efflux in MCs was lower than the control.

View Article and Find Full Text PDF

The aim of this review was to delve into the extent of mosquito virome coverage (proportion of viral reads) via meta-viromic sequencing and uncover potential factors of heterogeneity that could impact this coverage. Data sources were PubMed, Web of Science, Embase, Scopus, Science-Direct, Google Scholar, and the China National Knowledge Infrastructure. Pooled coverage was estimated using random-effects modeling, and subgroup analyses further reveal potential heterogeneous factors.

View Article and Find Full Text PDF

Cadmium (Cd) pollution poses a significant ecological risk to mangrove ecosystems. Trehalose has excellent potential to mitigate the adverse effects of heavy metals. Unfortunately, the mechanisms related to trehalose-mediated heavy metal tolerance in plants remain elusive.

View Article and Find Full Text PDF
Article Synopsis
  • The One Health approach integrates human, animal, and environmental health, promoting interdisciplinary collaboration to tackle global health challenges and requiring new assessment tools for effective implementation.
  • The enhanced Global One Health Index (GOHI) 2022 employs a comprehensive system of indices and sub-indicators, using a fuzzy analytic hierarchy process to analyze data across 160 countries/territories and provide insights into global health performance.
  • GOHI 2022 reveals significant disparities in health scores across regions, with a global average of 54.82, indicating that North America and Europe score higher, while antimicrobial resistance ranks as a notable weakness within the One Health framework.
View Article and Find Full Text PDF

One Health is an interdisciplinary approach that promotes the resolution of complex health issues through collaboration across multiple disciplines. In addition to accountability, the One Health governance structure fosters shared understanding, trust, and an appreciation for diverse perspectives and requirements. This article provides a comprehensive analysis of the current integration of the One Health approach within China's existing health governance framework.

View Article and Find Full Text PDF

One Health is dedicated to maintaining and fostering a dynamic balance among humans, animals, and the environment. Since 2013, it has seen considerable developments globally. This review aims to encapsulate the history of One Health, as well as chart its future trajectory.

View Article and Find Full Text PDF

Background: Schistosomiasis japonica represents a significant public health concern in South Asia. There is an urgent need to optimize existing schistosomiasis diagnostic techniques. This study aims to develop models for the different stages of liver fibrosis caused by Schistosoma infection utilizing ultrasound radiomics and machine learning techniques.

View Article and Find Full Text PDF

Objective: To understand the epidemiological distribution characteristics of mountain-type zoonotic visceral leishmaniasis (MT-ZVL) in Yangquan City, Shanxi Province, China, from 2006 to 2021, to explore the influencing factors leading to the re-emergence of the epidemic, and to provide a basis for the formulation of targeted control strategies.

Methods: Case information spanning from 2006 to 2021 in Yangquan City was collected for a retrospective case-control study conducted from June to September 2022. A 1:3 matched ratio was employed.

View Article and Find Full Text PDF
Article Synopsis
  • The One Health (OH) approach aims to control zoonotic events but lacks systematic assessment tools; this study applied the Global OH Index (GOHI) specifically for zoonoses.
  • By using fuzzy analytic hierarchy process and fuzzy comparison matrix, the study evaluated 160 countries based on five key indicators to determine their OH performance regarding zoonoses.
  • Results showed significant variations in GOHI-Zoonoses scores linked to factors like economics and environmental conditions, indicating areas for improvement in global strategies to enhance health across humans, animals, and the environment.
View Article and Find Full Text PDF

Hepatocellular carcinoma (HCC) accounts for over 80% of cases among liver cancer, with high incidence and poor prognosis. Thus, it is of valuable clinical significance for discovery of potential biomarkers and drug targets for HCC. In this study, based on the proteomic profiling data of paired early-stage HCC samples, we found that RNF149 was strikingly upregulated in tumor tissues and correlated with poor prognosis in HCC patients, which was further validated by IHC staining experiments of an independent HCC cohort.

View Article and Find Full Text PDF

Objective: Precision interventions have been proposed in transmission-interrupted areas to further reduce the potential transmission risk of schistosomiasis. This study aimed to evaluate the effects of different interventions modes for potential transmission risk control.

Methods: Three groups of schistosomiasis-endemic villages were selected in Jiangling county, Hubei province.

View Article and Find Full Text PDF

Background: Data-driven research is a very important component of One Health. As the core part of the global One Health index (GOHI), the global One Health Intrinsic Drivers index (IDI) is a framework for evaluating the baseline conditions of human-animal-environment health. This study aims to assess the global performance in terms of GOH-IDI, compare it across different World Bank regions, and analyze the relationships between GOH-IDI and national economic levels.

View Article and Find Full Text PDF

Background: One Health has become a global consensus to deal with complex health problems. However, the progress of One Health implementation in many countries is still relatively slow, and there is a lack of systematic evaluation index. The purpose of this study was to establish an indicator framework for global One Health Intrinsic Drivers index (GOH-IDI) to evaluate human, animal and environmental health development process globally.

View Article and Find Full Text PDF
Article Synopsis
  • Zoonoses pose a major public health risk, and the One Health (OH) approach is crucial for their control; a global OH index (GOHI) was recently developed to assess this performance in sub-Saharan Africa.
  • An OH index on zoonoses (OHIZ) was created using five indicators and extensive data from 48 countries to evaluate zoonotic disease control, with results highlighting varying levels of performance across the region.
  • The average OHIZ score for sub-Saharan Africa was 53.67/100, with South Africa scoring the highest and Benin the lowest, indicating that while there are strengths in disease surveillance and response, improvements are still needed overall.
View Article and Find Full Text PDF

Background: Dengue has become one of the major vector-borne diseases, which has been an important public health concern. We aimed to estimate the disease burden of dengue in major endemic regions from 1990 to 2019, and explore the impact pattern of the socioeconomic factors on the burden of dengue based on the global burden of diseases, injuries, and risk factors study 2019 (GBD 2019).

Methods: Using the analytical strategies and data from the GBD 2019, we described the incidence and disability-adjusted life years (DALYs) of dengue in major endemic regions from 1990 to 2019.

View Article and Find Full Text PDF

What Is Already Known About This Topic?: Neurocysticercosis is the most severe form of infection caused by ingesting cysticerci, the larval cysts of the pork tapeworm, Approximately 50 million people worldwide have neurocysticercosis, which is the leading cause of acquired epilepsy in many endemic countries.

What Is Added By This Report?: The health of neurocysticercosis patients can be seriously impaired, including through loss of mobility, inability to do self-care, impairment of usual activities, pain/discomfort, anxiety/depression, and impaired cognition. Cognitive impairment is the major consequence of neurocysticercosis and significant contributor to decreased health-related quality of life.

View Article and Find Full Text PDF

Background: A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.

View Article and Find Full Text PDF

Background: The One Health (OH) concept has been promoted widely around the globe. OH framework is expected to be applied as an integrated approach to support addressing zoonotic diseases as a significant global health issue and to improve the efficiency and effectiveness of zoonosis prevention and control. This review is intended to overview the social impact of the implementation of OH on zoonosis prevention and control.

View Article and Find Full Text PDF

Glioblastoma multiforme (GBM) is the most common in situ neoplasms in central nervous system (CNS). However, the pathogenesis of GBM is poorly understood. Long noncoding RNAs (lncRNAs) have been implicated in GBM progression.

View Article and Find Full Text PDF

Aim: The study was conducted to investigate the antibacterial and antiasthmatic effects of leaf extract, to find out its active components, and to assess its safety issue.

Methods: (1) Solid-phase agar dilution method was used for antibacterial activity test of nandina leaf extract and the change of bacterial morphology after treatment was observed under the transmission microscope; (2) guinea pig model of asthma was used to test the asthma prevention effect of nandina leaf extract; (3) alkaloids and flavones were separated from nandina leaf extract and were further analyzed with HPLC-MS; (4) mice model was used to assessment of the safety issue of nandina leaf extract.

Results: (1) Nandina leaf extract inhibited the growth of bacteria and destroyed bacterial membrane; (2) nandina leaf extract alleviated animal allergy and asthma; (3) the components reextracted by ethyl acetate were active, in which alkaloids inhibited Gram-positive bacteria and prevented asthma and flavones inhibited Gram-negative bacteria; (4) nandina leaf extract had no toxic effect on mice.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionbbkapicilihj9f1rvtqmdqn2ttf8g2qm): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once