Publications by authors named "Zhaoyong Shou"
Article Synopsis
- The study analyzed the toxicity and mechanisms of giant jellyfish venom extracted from tentacles (TE) and nematocysts (NV), identifying 239 and 225 toxin proteins respectively.
- Both extracts caused heart and liver damage through cell death and inflammation, with TE showing greater toxicity in experiments.
- The research also suggested that PACOCF3, a phospholipase A2 inhibitor, significantly improved survival rates in mice, highlighting its potential as an antidote and the importance of extraction methods for studying jellyfish venom.
Comparison of the structure-function of five newly members of the calcin family.
Int J Biol Macromol
March 2024
Calcins are a group of scorpion toxin peptides specifically binding to ryanodine receptors (RyRs) with high affinity, and have the ability to activate and stabilize RyR in a long-lasting subconductance state. Five newly calcins synthesized compounds exhibit typical structural characteristics of a specific family through chemical synthesis and virtual analysis. As the calcins from the same species, Petersiicalcin1 and Petersiicalcin2, Jendekicalcin2 and Jendekicalcin3, have only one residue difference.
View Article and Find Full Text PDFEthnopharmacological Relevance: As well-known medicinal materials in traditional Chinese medicine, scorpions, commonly called as Quanxie () in Chinese, have been widely used to treat several diseases such as rheumatoid arthritis, apoplexy, epilepsy and chronic pain for more than a thousand years. Not only in the ancient times, the scorpions have also been recorded nowadays in the Pharmacopoeia of the People's Republic of China since 1963.
Aim Of Study: This study aims to explore the differences in composition of the venom of scorpions from different regions by using the method of transcriptomics and proteomics.