Photoredox/Copper Dual-Catalyzed Phosphorothiolation of Propargylic Derivatives for the Switchable Synthesis of -Alkyl, -Vinyl and -Allenyl Phosphorothioates.

Herein, we report a photoredox/copper dual-catalyzed selective phosphorothiolation of propargylic derivatives from easily accessible [P(O)SH] compounds. This reaction provides a general, mild and versatile procedure to synthesize a variety of synthetically useful -alkyl, -vinyl and -allenyl phosphorothioates selectively from the same set of simple starting materials.

Two new unsaturated fatty acids from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22.

Two new unsaturated fatty acids, 6R,8R-dihydroxy-9Z,12Z-octadecadienoic acid (1) and methyl-6R,8R-dihydroxy-9Z,12Z-octadecadienoate (2), and two known 9Z,12Z-octadecadienoic acid analogues (3, 4) together with a known sesquiterpenoid (5) were isolated from the mangrove rhizosphere soil-derived fungus Penicillium javanicum HK1-22. An acetonide derivative (1a) from 1 was also prepared. The relative configuration of 1 was determined by analysis of the 1D and 2D NOE spectra of 1a.

New Naphtho-γ-Pyrones Isolated from Marine-Derived Fungus sp. HK1-22 and Their Antimicrobial Activities.

Three novel monomeric naphtho-γ-pyrones, peninaphones A-C (compounds -), along with two known bis-naphtho-γ-pyrones (compounds and ) were isolated from mangrove rhizosphere soil-derived fungus sp. HK1-22. The absolute configurations of compounds and were determined by electronic circular dichroism (ECD) spectra, and the structure of compound was confirmed by single-crystal X-ray diffraction analysis.

Paraherquamide J, a new prenylated indole alkaloid from the marine-derived fungus HK1-6.

A new prenylated indole alkaloid, named paraherquamide J (), together with four known compounds (-), were isolated from the mangrove rhizosphere soil-derived fungus HK1-6. The planar structure and relative configuration of were determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. The absolute configuration of was determined by ECD spectra.

Understanding how a sport-helmet protects the head from closed injury by virtual impact tests.

Understanding how a helmet protects the head, especially the soft brain tissues, is the prerequisite for improving helmet design. Intracranial pressure and stresses/strains in the brain tissues are the direct indicators of traumatic brain injury and they can be used to measure helmet performance. In this study, the effects of helmet design parameters such as the helmet shell stiffness, liner compliance and thickness on the brain injury indicators were investigated by virtual impact tests.

A QCT-Based Nonsegmentation Finite Element Head Model for Studying Traumatic Brain Injury.

In the existing finite element head models (FEHMs) that are constructed from medical images, head tissues are usually segmented into a number of components according to the interior anatomical structure of the head. Each component is represented by a homogenous material model. There are a number of disadvantages in the segmentation-based finite element head models.

Sport helmet design and virtual impact test by image-based finite element modeling.

Head injury has been a major concern in various sports, especially in contact sports such as football and ice hockey. Helmet has been adopted as a protective device in such sports, aiming at preventing or at least alleviating head injuries. However, there exist two challenges in current helmet design and test.

[The common causes of conversion of VATS during operation for 248 non-small cell lung cancers].

Background And Objective: VATS-lobectomy has been used as regular surgical procedure clinically for non-small cell lung cancer. The aim of this study is to evaluate the surgical emergencies during VATS and the related factors postoperatively.

Methods: Clinical data were reviewed for patients who were performed with pulmonary related surgery between January 2006 and July 2008 in our department.

[Correlation of 3'-deoxy-3'-18F-fluorothymidine uptake to cell proliferation in lung carcinoma xenografts].

Background & Objective: 3'-Deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) has been described recently as a new positron emission tomography (PET) tracer for imaging tumor cell proliferation. This study was to investigate the biodistribution and PET imaging of (18)F-FLT in a murine model of lung cancer, and to explore the correlation of (18)F-FLT uptake to cell proliferation of lung cancer.

Methods: A total of 48 T739 mice bearing lung adeno-carcinoma were randomized into (18)F-FLT group and 2-(18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) group according to the radioactive tracers.