A study of brain networks associated with Freezing of gait in Parkinson's disease using transfer entropy analysis.

Background: Parkinson's disease (PD) is a common neurodegenerative disease in the elderly. Freezing of Gait (FOG) is one of the common motor symptoms of PD, but the potential mechanism remains unclear. This study aimed to investigate the changes of brain functional network topology in PD patients with FOG.

Investigating PM responses to other air pollutants and meteorological factors across multiple temporal scales.

It remains unclear on how PM interacts with other air pollutants and meteorological factors at different temporal scales, while such knowledge is crucial to address the air pollution issue more effectively. In this study, we explored such interaction at various temporal scales, taking the city of Nanjing, China as a case study. The ensemble empirical mode decomposition (EEMD) method was applied to decompose time series data of PM, five other air pollutants, and six meteorological factors, as well as their correlations were examined at the daily and monthly scales.

Synthesis and biological evaluation of nitric oxide (NO)-hydrogen sulfide (HS) releasing derivatives of (S)-3-n-butylphthalide as potential antiplatelet agents.

In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of (S)-3-n-butylphthalide ((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid (AA)- and adenosine diphosphate (ADP)-induced platelet aggregation in vitro, with 3.8- and 7.

[Advances in hydrogen sulfide and hydrogen sulfide-releasing drugs].

Hydrogen sulfide (H(2)S) is considered as a new member of gasotransmitter family, following nitric oxide (NO) and carbon monoxide (CO). H2S exerts important biological effects in mammals, which has drawn more and more attention in recent years. It is proved that H(2)S has a role in the regulation of physiological and pathophysiological processes in the cardiovascular system and the nervous system.