LINC00882, transcriptionally activated by CEBP-β and post-transcriptionally stabilized by METTL14-mediated mA modification, exerts tumorigenesis by promoting PABPC1-mediated stabilization of ELK3 mRNA.

Breast cancer (BC) is the most common malignant tumor in women, and the majority of BC-related deaths are due to tumor metastasis. There is emerging evidence for the role of long noncoding RNAs (lncRNAs) in tumor progression. Nevertheless, lncRNAs that drive metastasis in patients with BC and the underlying mechanisms of lncRNAs are still largely elusive.

LncRNA LY6E-DT and its encoded metastatic-related protein play oncogenic roles via different pathways and promote breast cancer progression.

Abnormal long noncoding RNA (lncRNA) expression plays an important role in tumor invasion and metastasis. Here, we show that lncRNA LY6E divergent transcript (LY6E-DT) levels are increased in breast cancer (BC) tissues. Transcription factor SP3 binds directly to the LY6E-DT promoter, activating its transcription.

CAP2 promotes gastric cancer metastasis by mediating the interaction between tumor cells and tumor-associated macrophages.

The metastasis of cancer cells is the main cause of death in patients with gastric cancer (GC). Mounting evidence has demonstrated the vital importance of tumor-associated macrophages in promoting tumor invasion and metastasis; however, the interaction between tumor cells and macrophages in GC is largely unknown. In this study, we demonstrated that cyclase-associated protein 2 (CAP2) was upregulated in GC, especially in cases with lymph node metastasis, and was correlated with a poorer prognosis.

Fabrication of a gel particle array in a microfluidic device for bioassays of protein and glucose in human urine samples.

This paper describes a simple method for fabricating a series of poly(ethylene glycol) diacrylate (PEG-DA) hydrogel microstructures inside microfluidic channels as probe for proteins and glucose. In order to demonstrate the feasibility of this newly developed system, bovine serum albumin (BSA) was chosen as a model protein. PEG microcolumns were used for the parallel detection of multiple components.

A simple microfluidic chlorine gas sensor based on gas-liquid chemiluminescence of luminol-chlorine system.

In this work, a microfluidic chlorine gas sensor based on gas-liquid interface absorption and chemiluminescence detection was described. The liquid chemiluminescence reagent-alkaline luminol solution can be stably sandwiched between two convex halves of a microchannel by surface tension. When chlorine gas was introduced into the micro device, it was dissolved into the interfacial luminol solution and transferred to ClO(-), and simultaneously luminol was excited and chemiluminescence emitted.