Publications by authors named "Zhaoxia Liang"
Background: Gestational diabetes mellitus (GDM) women require prenatal care to minimize short- and long-term complications. The mechanism by which exercise during pregnancy affects organ development and whether glucose transporter (GLUT) 1 plays a role in GDM offspring organ development remains unknown.
Aim: To determine the effect of exercise during pregnancy on the cardiac, hepatic and renal development of GDM mother's offspring.
Aims: This study aims to determine whether postpartum body mass index (BMI) trajectories and its time in target range (TTR) are associated with long-term type 2 diabetes risk in women with a history of gestational diabetes mellitus (GDM).
Materials And Methods: The present study included 1057 women with a history of GDM who participated in the Tianjin Gestational Diabetes Mellitus Prevention Program (TGDMPP). Oral glucose tolerance tests or physician-diagnosed information were used to diagnose type 2 diabetes after a median follow-up period of 8.
Purpose: Gestational diabetes mellitus (GDM) could increase the risks of type 2 diabetes mellitus (T2DM) and cardiovascular disease. However, evidence on its association with cardiometabolic multimorbidity (CMM) was limited. This study aimed to evaluate the association between GDM and the prevalence, incidence, patterns, and progression of CMM; and the role of body mass index (BMI) in such association.
View Article and Find Full Text PDFBackground: Gestational diabetes mellitus (GDM) can lead to various adverse pregnancy outcomes for both mothers and infants, including gestational hypertension, premature rupture of membranes, preterm birth, macrosomia, large for gestational age (LGA) infants, and neonatal hypoglycemia. Previous studies have mainly focused on the overall risk of GDM for adverse maternal and neonatal outcomes, but there has been limited research specifically investigating the relationship between different patterns of abnormal oral glucose tolerance test (OGTT) results and adverse maternal and neonatal outcomes.
Objective: The study aimed to analyze the maternal and neonatal outcomes among GDM women with different OGTT patterns and to explore a new classification method capable of stratifying GDM into high-risk (GDM-HR) and low-risk subtypes based on OGTT results.
Article Synopsis
- This study investigates how changes in glycated hemoglobin (HbA1c) during the second and third trimesters impact pregnancy outcomes for women not experiencing hyperglycemia in pregnancy (HIP).
- It analyzed data from 1,057 pregnant women, revealing that higher HbA1c levels in either trimester are linked to an increased risk of hypertensive disorders and larger babies at birth.
- The findings highlight that a rise in HbA1c levels correlates with a nearly twofold increase in the risk of hypertensive disorders and a significant chance of delivering larger-than-average babies, emphasizing the need for monitoring HbA1c in pregnant women without HIP.
Article Synopsis
- A study investigated the outcomes of elective labor induction at 39 weeks versus expectant management, focusing on risks and benefits related to neonatal and maternal health.
- The research included over 21,000 participants from January 2019 to June 2022, dividing them into multiple groups based on their delivery timing and method.
- Findings indicated that elective induction at 39 weeks was associated with lower risks for adverse outcomes compared to those managed expectantly, suggesting potential advantages for planned inductions.
Background: Breastfeeding is widely recognized for its potential to reduce childhood obesity. However, research investigating these benefits in children breastfed for a short duration (up to 6 months) remains limited despite this being a common practice globally.
Methods: This study focused on a population breastfed for 6 months or less to determine the potential benefits of short-term breastfeeding for preventing childhood obesity.
The relationship between co-exposure to multiple metals and gestational diabetes mellitus (GDM) and the mechanisms involved are poorly understood. In this nested case-control study, 228 GDM cases and 456 matched controls were recruited, and biological samples were collected at 12-14 gestational weeks. The urinary concentrations of 10 metals and 8-hydroxydeoxyguanosine (8-OHdG) as well as the serum levels of malondialdehyde (MDA) and advanced glycation end products (AGEs) were determined to assess the association of metals with GDM risk and the mediating effects of oxidative stress.
View Article and Find Full Text PDFBackground: Pregnant women faced great challenges and psychological and physiological changes of varying degrees during the omicron epidemic outbreak. It is important to recognize the potential impact of these challenges on the mental health of pregnant women and to provide appropriate resources and support to mitigate their effects.
Method: By using the convenience sampling approach, a total of 401 pregnant women from two hospitals of different grades in two cities were included in the survey.
Aim: To prospectively assess the association of smoking timing with the risk of type 2 diabetes (T2D) and examine whether smoking amount or genetic susceptibility might modify the relationship.
Materials And Methods: A total of 294 815 participants without diabetes from the UK Biobank, including non-smokers and smokers with data on the time from waking to first cigarette, were included. Cox proportional hazards models were used to evaluate the association between smoking timing and the risk of incident T2D.
Background: It is still unclear whether social support can moderate the high risk of depression and anxiety due to spontaneous miscarriage.
Objective: This study prospectively investigated the associations of spontaneous miscarriage with risks of depression and anxiety, and evaluated the interactions between spontaneous miscarriage and the degree of social support in relation to depression and anxiety risks.
Study Design: A total of 179,000 participants from the UK Biobank with pregnancy experience and without depression or anxiety at baseline were included.
Psychological Status of Medical Staff in Obstetrics and Gynecology Hospitals during the Omicron Pandemic Outbreak in China.
Can J Infect Dis Med Microbiol
February 2024
Background: Medical staff in China faced great challenges and psychological and physiological changes of varying degrees during the omicron epidemic outbreak. It is important to recognize the potential impact of these challenges on the mental health of medical staff and to provide appropriate resources and support to mitigate their effects.
Methods: A total of 354 medical staff in two obstetrics and gynecology hospitals of different grades were included in this survey using convenience sampling.
Aim: Women with diabetes are at higher risk of cardiovascular diseases (CVD) than men with diabetes; however, the sex difference in the association between the degree of risk factor control and the risk of CVD in patients with diabetes is unclear.
Methods: In total, 17 260 participants diagnosed with diabetes from the UK Biobank were included and matched with 86 300 non-diabetes controls based on age, sex and assessment centre. The main exposure was the number of risk factors within the target range, including glycated haemoglobin level <53 mol/mol (7%), blood pressure <140/90 mm/Hg, low-density lipoprotein cholesterol <100 mg/dl, non-current smoking and absence of microalbuminuria.
Introduction: Maternal height has been shown to be associated with adverse outcomes in women with gestational diabetes mellitus (GDM). The aim of this study is to evaluate the association between maternal height and adverse outcomes stratified for gestational weight gain (GWG) and pre-pregnancy body mass index (BMI) in women with GDM.
Methods: We conducted a retrospective study that included 2048 women diagnosed with GDM during 24-28 gestational weeks from July 1, 2017, to June 30, 2018, in Zhejiang Province, China.
Background: The American Heart Association recently updated Life's Essential 8 (LE8) score. This amalgamation of health factors, recognized for their individual associations with chronic kidney disease (CKD) risk, provides a robust tool to assess overall cardiovascular health (CVH), which could potentially be extrapolated to predict CKD risk.
Objectives: This study aimed to investigate the association between levels of CVH, as measured by the LE8 score, and risk of CKD in the UK Biobank.
BMI change during childhood, DNA methylation change at TXNIP, and glucose change during midlife.
Obesity (Silver Spring)
August 2023
Objective: This study investigated whether changes in DNA methylation (DNAm) at TXNIP are associated with glycemic changes and whether such an association differs with early-life adiposity changes.
Methods: A total of 594 Bogalusa Heart Study participants who had blood DNAm measurements at two time points in midlife were included. Of them, 353 participants had at least four BMI measurements during childhood and adolescence.
Objectives: The gestational weight gain (GWG) and hyperglycemia are two key factors affecting adverse pregnancy outcomes among women with gestational diabetes mellitus (GDM). We aimed to investigate the combinatorial effect of abnormal glucose metabolism and GWG on adverse outcomes in GDM.
Methods: This retrospective cohort study included 2611 pregnant women with GDM in Women's Hospital School of Medicine Zhejiang University.
Background: Cardiovascular disease may be the main reason for stagnant growth in life expectancy in the United States since 2010. The American Heart Association recently released an updated algorithm for evaluating cardiovascular health (CVH)-Life's Essential 8 (LE8) score. We aimed to quantify the associations of CVH levels, estimated by the LE8 score, with life expectancy in a nationally representative sample of US adults.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to examine how stress experienced by pregnant women in their second trimester affects pregnancy outcomes, particularly focusing on body mass index (BMI) before pregnancy and weight gain during pregnancy.
- Researchers analyzed data from 960 pregnant women and found that stressed women had a significantly higher incidence of premature rupture of membranes (PROM) compared to non-stressed women, while other complications showed no significant differences.
- The results indicate that second-trimester stress is a key risk factor for PROM, especially in women with a normal pre-pregnancy BMI, suggesting that reducing stress could be important for improving pregnancy outcomes in this group.
The association between maternal HbA1c and adverse outcomes in gestational diabetes.
Front Endocrinol (Lausanne)
April 2023
Background: The role of HbA1c in women with gestational diabetes mellitus (GDM) is still unclear, particularly in the Asian population.
Aim: To investigate the association between HbA1c levels and adverse outcomes considering maternal age, pre-pregnancy body mass index (BMI), and gestational weight gain (GWG) in women with GDM.
Method: A retrospective study included 2048 women with GDM and singleton live births.
Article Synopsis
- Diabetic foot ulcers (DFUs) are a significant and growing health issue for diabetes patients, leading to increased morbidity and emphasizing the need for effective diagnosis and treatment.
- The wound healing process involves three stages: inflammation, proliferation, and regeneration, and the role of non-coding RNAs (ncRNAs) has gained attention in understanding these stages and diabetes complications.
- Dysregulation of ncRNAs may contribute to DFU progression and delayed healing, making them potential targets for new diagnostic and therapeutic strategies in managing diabetic wounds.
Introduction: To explore the independent and combined effects of maternal age, pre-pregnancy body mass index (BMI), and gestational weight gain (GWG) on pregnancy outcomes in gestational diabetes mellitus (GDM).
Methods: A total of 2171 pregnant women with GDM attending the Women's Hospital of Zhejiang University were retrospectively included. We compared pregnancy outcomes in different age, BMI, and GWG groups after adjusting for confounding variables.
Article Synopsis
- Gestational diabetes mellitus (GDM) is linked to poor pregnancy outcomes and issues with fetoplacental endothelial function, but the specific mechanisms are not fully understood.
- This study focused on how exosomal miRNAs from the placenta (specifically miR-140-3p and miR-574-3p) affect endothelial cell functions in GDM and the role of chemerin in this process.
- Findings show that lower levels of these miRNAs in GDM promote inflammation through chemerin, which in turn enhances endothelial cell function, suggesting potential new targets for treatment of GDM and related complications.
Background: To investigate the influence of HbA1c level and GWG on pregnancy outcomes in pregnant women with GDM.
Methods: A total of 2,171 pregnant women with GDM were retrospectively included and categorized as follows: (1) normal (HbA1c <6%) and elevated (HbA1c ≥6%) HbA1c groups according to the HbA1c level in the second trimester, and (2) inadequate, appropriate, and excessive GWG groups according to the IOM guidelines.
Results: In pregnant women with GDM, advanced age and high pre-pregnancy BMI were high-risk factors for elevated HbA1c.
Objectives: To evaluate the influence of genetic variants and clinical characteristics on the risk of gestational diabetes mellitus (GDM) and to construct and verify a prediction model of GDM in early pregnancy.
Methods: Four hundred seventy five women with GDM and 487 women without, as a control, were included to construct the prediction model of GDM in early pregnancy. Both groups had complete genotyping results and clinical data.