Giant Piezoelectric Coefficient of Polyvinylidene Fluoride with Rationally Engineered Ultrafine Domains Achieved by Rapid Freezing Processing.

Domains play an essential role in determining the piezoelectric properties of polymers. The conventional method for achieving ultrafine piezoelectric domain structures for polymers is multiphase polymerization, which is not the primary choice for industrial-scale applications because of its complex synthesis and weak mechanical properties. In this study, it is demonstrated for the first time that a nanoscale domain design can be achieved in a commercially available polyvinylidene fluoride (PVDF) homopolymer through a simple fabrication method involving cyclic compression and rapid freezing.

Description of the mitochondrial genomes of Sichuan Tetrastes sewerzowi (Galliformes: Tetraonidae) and phylogenetic relationship.

The Chinese Grouse (Tetrastes sewerzowi), a rare endemic bird in China, belongs to the Galliformes order and Tetraonidae family. Despite extensive research, subspecies classification remains inadequate, especially in Pingwu, Sichuan. This study sequenced the mitochondrial genome of T.

A Peculiar Tau Accumulation Pattern Identified Via 18 F-Florzolotau PET Imaging in a Patient With Frontotemporal Dementia Caused by a Mutation in the MAPT Gene.

We reported imaging findings with a peculiar tau accumulation pattern in a 56 year-old woman with frontotemporal dementia caused by Q351R mutation in the microtubule-associated protein tau ( MAPT ) gene. She had a 10-year history of gradually worsening memory loss. 18 F-FDG PET demonstrated hypometabolism in medial temporal lobes, but 18 F-florbetapir PET manifested no abnormal amyloid beta deposition, which ruled out Alzheimer disease.

The effects of mindfulness therapy on infertile female patients: A meta-analysis.

Background: About 186 million people in the world suffer from infertility, and there is one infertile couple in every 4-6 couples. It is thus essential to find effective psychological treatment.

Objective: To conduct a systematic review of previous meta-analyses on mindfulness-based therapy outcomes in infertile female patients and a meta-analysis of studies nested within these meta-analyses.

Highly Tribo-Positive Nylon-11 Film Fabricated by Multiscale Structural Regulation through a Roll-to-Roll Processing.

Triboelectric polymers have attracted extensive attention due to their great electron-accepting and electron-donating properties in contact electrification as well as their flexible and low-cost merits and have become promising electrode materials in triboelectric nanogenerators (TENGs). However, most research has exclusively focused on improving the electron capture capability of the triboelectric layer, neglecting to enhance the electron-donating capability, which leads to a low output performance of TENG and limits its practical application. In this study, we developed a method to fabricate highly tribo-positive Nylon-11 film through roll-to-roll processing.

Immunization with a peptide mimicking lipoteichoic acid induces memory B cells in BALB/c mice.

Background: There is an urgent clinical need for developing novel immunoprophylaxis and immunotherapy strategies against Staphylococcus aureus (S. aureus). In our previous work, immunization with a tetra-branched multiple antigenic peptide, named MAP2-3 that mimics lipoteichoic acid, a cell wall component of S.

Self-poled piezoelectric polymer composites via melt-state energy implantation.

Lightweight flexible piezoelectric polymers are demanded for various applications. However, the low instinctively piezoelectric coefficient (i.e.

Acid-Doped Pyridine-Based Polybenzimidazole as a Positive Triboelectric Material with Superior Charge Retention Capability.

The energy conversion efficiency of a triboelectric nanogenerator (TENG) is severely limited by the charge density of triboelectric materials, while drastic and unavoidable charge decay happens during contact due to the insufficient charge retention capacity of positive triboelectric materials. Here, elaborately synthesized acid-ion-doped pyridine-based polybenzimidazole processing with strong charge retention capability is demonstrated to couple with negatively corona-polarized electrets. As illustrated by thermal stimulation and an ion mass spectrometer, the formation of acid-ion chimerism processes high activation energy for stored charges, and the selective anion migration can compensate the escape of polarized charge.

The effect of different angle kappa on higher-order aberrations after small incision lenticule extraction.

This study aimed to compare higher-order aberrations (HOAs) after small incision lenticule extraction (SMILE) in patients with different angle kappa. This is a retrospective report in which 341 right eyes of 341 patients who were subjected to SMILE, which used coaxially sighted corneal light reflex (CSCLR) as the treatment zone centered, treated by the same experienced surgeon (LHB) for correction of myopia and myopic astigmatism, preoperative and postoperative spherical equivalent (SE), angle kappa, total higher-order aberrations (total HOA), spherical aberration (SA), vertical coma (VC), horizontal coma (HC), oblique trefoil (OT), and horizontal trefoil (HT), were compared. SMILE showed outstanding performance in terms of safety, efficacy, and predictability.

Water evaporation induced in-situ interfacial compatibilization for all-natural and high-strength straw-fiber/starch composites.

In this paper, we proposed a novel and green strategy based on water evaporation induced in-situ interfacial compatibilization (WEIC) mechanism for fabricating high-strength and all-natural lignocellulose/starch composites. This mechanism exploits the natural compatibility of the lignocellulose and starch and was tested through an internal mixing process with regulated water evaporation. Specifically, we revealed that a restrained layer was in-situ formed at the interface of the lignocellulose and starch during the internal mixing process; a faster water evaporation rate thickens this restrained layer, restricts the starch's molecular movement and significantly increases the composite's mechanical properties.

Deep Learning-Based Health Management Model Application in Extreme Myopia Eye Vision Monitoring and Risk Prediction.

According to statistics released by the WHO, China has the highest prevalence of myopia in the world, with a frequency that is 1.5 times higher than the global average. Asians have the highest prevalence of myopia worldwide.

MAB21L1 promotes survival of lens epithelial cells through control of αB-crystallin and ATR/CHK1/p53 pathway.

The male abnormal gene family 21 (), was initially identified in . Since its identification, studies from different groups have shown that it regulates development of ocular tissues, brain, heart and liver. However, its functional mechanism remains largely unknown.

Fabrication of triboelectric polymer films via repeated rheological forging for ultrahigh surface charge density.

Triboelectric polymer with high charge density is the foundation to promote the wide range of applications of triboelectric nanogenerators. This work develops a method to produce triboelectric polymer based on repeated rheological forging. The fluorinated ethylene propylene film fabricated by repeated forging method not only has excellent mechanical properties and good transmittance, but also can maintain an ultrahigh tribo-charge density.

Crystal Structures of Bat and Human Coronavirus ORF8 Protein Ig-Like Domain Provide Insights Into the Diversity of Immune Responses.

ORF8 is a viral immunoglobulin-like (Ig-like) domain protein encoded by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA genome. It tends to evolve rapidly and interfere with immune responses. However, the structural characteristics of various coronavirus ORF8 proteins and their subsequent effects on biological functions remain unclear.

Deubiquitinase ZRANB1 drives hepatocellular carcinoma progression through SP1-LOXL2 axis.

Deubiquitinase (DUB) zinc finger RANBP2-type containing 1 (ZRANB1) has been reported to have a close relationship with cancers. However, its underlying role and molecular mechanisms in hepatocellular carcinoma (HCC) remain elusive. In this study, we demonstrated that ZRANB1 was highly expressed in HCC tissues.

Structural Basis of a Human Neutralizing Antibody Specific to the SARS-CoV-2 Spike Protein Receptor-Binding Domain.

The emerging new lineages of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) have marked a new phase of coronavirus disease 2019 (COVID-19). Understanding the recognition mechanisms of potent neutralizing monoclonal antibodies (NAbs) against the spike protein is pivotal for developing new vaccines and antibody drugs. Here, we isolated several monoclonal antibodies (MAbs) against the SARS-CoV-2 spike protein receptor-binding domain (S-RBD) from the B cell receptor repertoires of a SARS-CoV-2 convalescent.

Hierarchically Architected Polyvinylidene Fluoride Piezoelectric Foam for Boosted Mechanical Energy Harvesting and Self-Powered Sensor.

With the rapid development of wearable electronics, piezoelectric materials have received great attention owing to their potential solution to the portable power source. To enhance the output capability and broaden the application, it is highly desired for the design of piezoelectric materials with a three-dimensional and porous structure to facilitate strain accumulation. Herein, enlightened by hierarchical structures in nature, a hierarchically nested network was constructed in polyvinylidene fluoride (PVDF) foam via solid-state shear milling and salt-leaching technology.

Structural characteristics of coiled-coil regions in AF10-DOT1L and AF10-inhibitory peptide complex.

The interaction of the solo H3K79 methyltransferase DOT1-like (DOT1L) and its regulatory factor ALL1-fused gene from chromosome 10 protein (AF10) is crucial for the transcription of developmental genes such as HOXA in acute leukemia. The octapeptide motif and leucine zipper region of AF10 is responsible for binding DOT1L and catalyzing H3K79 monomethylation to demethylation. However, the characteristics of the mechanism between DOT1L and AF10 are not clear.

A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation.

Although human antibodies elicited by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein are profoundly boosted upon infection, little is known about the function of N-reactive antibodies. Herein, we isolate and profile a panel of 32 N protein-specific monoclonal antibodies (mAbs) from a quick recovery coronavirus disease-19 (COVID-19) convalescent patient who has dominant antibody responses to the SARS-CoV-2 N protein rather than to the SARS-CoV-2 spike (S) protein. The complex structure of the N protein RNA binding domain with the highest binding affinity mAb (nCoV396) reveals changes in the epitopes and antigen's allosteric regulation.

Helically Intersected Conductive Network Design for Wearable Electronic Devices: From Theory to Application.

Flexible and stretchable strain sensors are crucial components for wearable electronics that can detect and quantify the stimuli from the environment and thus realize the rapid feedback and control of smart devices. However, reconciliation of the conflict between resourceful design of conductive networks and large-scale production in the industry still faces a huge challenge. Herein, we present a new flow-manipulated strategy to prepare a wearable strain sensor featuring a helically intersected conductive network, which exhibited easy integration, multidimensional sensibility, and robust mechanical properties.

Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14 monocytes.

Dysregulated immune cell responses have been linked to the severity of coronavirus disease 2019 (COVID-19), but the specific viral factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were currently unknown. Herein, we reveal that the Immunoglobulin-like fold ectodomain of the viral protein SARS-CoV-2 ORF7a interacts with high efficiency to CD14 monocytes in human peripheral blood, compared to pathogenic protein SARS-CoV ORF7a. The crystal structure of SARS-CoV-2 ORF7a at 2.

Structural Insight Into the SARS-CoV-2 Nucleocapsid Protein C-Terminal Domain Reveals a Novel Recognition Mechanism for Viral Transcriptional Regulatory Sequences.

Coronavirus disease 2019 (COVID-19) has caused massive disruptions to society and the economy, and the transcriptional regulatory mechanisms behind the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are poorly understood. Herein, we determined the crystal structure of the SARS-CoV-2 nucleocapsid protein C-terminal domain (CTD) at a resolution of 2.0 Å, and demonstrated that the CTD has a comparable distinct electrostatic potential surface to equivalent domains of other reported CoVs, suggesting that the CTD has novel roles in viral RNA binding and transcriptional regulation.

Structural characterization of cystathionine γ-lyase smCSE enables aqueous metal quantum dot biosynthesis.

The development and utilization of inorganic material biosynthesis have evolved into single macromolecular systems. A putative cystathionine γ-lyase of bacteria Stenotrophomonas maltophilia (smCSE) is a newly identified biomolecule that enables the synthesis of nanomaterials. Due to the lack of structural information, the mechanism of smCSE biosynthesis remains unclear.

From Waste to Wealth: A Lightweight and Flexible Leather Solid Waste/Polyvinyl Alcohol/Silver Paper for Highly Efficient Electromagnetic Interference Shielding.

With the popularization of 5G communications and the internet of things, electromagnetic wave (EW) radiation pollution has aroused much concern from the public, and the search for new materials and technologies for preparing electromagnetic shielding materials still continues all around the world. However, the contradiction among high shielding performance, economic applicability, and flexibility is still not well balanced. Herein, we fabricated a novel foldable leather solid waste (LSW)/polyvinyl alcohol (PVA)/silver (Ag) paper with excellent electromagnetic interference (EMI)-shielding ability using a facile but sustainable electroless plating (ELP) method with LSW as the resource.