Protein-Protein Interaction Sites Prediction Based on an Under-Sampling Strategy and Random Forest Algorithm.

The computational methods of protein-protein interaction sites prediction can effectively avoid the shortcomings of high cost and time in traditional experimental approaches. However, the serious class imbalance between interface and non-interface residues on the protein sequences limits the prediction performance of these methods. This work therefore proposed a new strategy, NearMiss-based under-sampling for unbalancing datasets and Random Forest classification (NM-RF), to predict protein interaction sites.

Role of charge accumulation in guided streamer evolution in helium DBD plasma jets.

Experimental data are presented on the evolution of a helium atmospheric pressure plasma jet driven by a tailored voltage waveform generated as bunches of voltage pulses consisting of a superposition of [Formula: see text] kHz bipolar square pulses and [Formula: see text] kHz oscillations. The characteristics of directed ionization waves (guided streamers) are compared for bunches with different first pulse polarities and different bunch duty cycles. The longest and brightest streamers are achieved at the voltage bunch with the first negative pulse and a minimum duty cycle.

Autophagy regulation revealed by SapM-induced block of autophagosome-lysosome fusion via binding RAB7.

The mechanism underlying autophagy alteration by mycobacterium tuberculosis remains unclear. Our previous study shows LpqH, a lipoprotein of mycobacterium tuberculosis, can cause autophagosomes accumulation in murine macrophages. It is well known that SapM, another virulence factor, plays an important role in blocking phagosome-endosome fusion.

Interleukin 17A and interleukin 17F polymorphisms are associated with oral squamous cell carcinoma susceptibility in a Chinese population.

Purpose: Several studies have investigated the association of the interleukin (IL) 17A and IL-17F polymorphisms and cancer of various organs. However, the role of the IL-17A and IL-17F polymorphisms in oral squamous cell carcinoma (OSCC) remains unclear. Thus we sought to clarify the association of the rs2275913, rs763780, and rs2397084 polymorphisms with OSCC in a Chinese population.

Autophagy-targeted vaccine of LC3-LpqH DNA and its protective immunity in a murine model of tuberculosis.

The development of more effective antituberculosis vaccines would contribute to the control of the global problem of infection with Mycobacterium tuberculosis (MTB). Recently, the highlighted importance of autophagy in the host immune response against MTB has attracted the attention of researchers. However, the vaccines targeted at autophagy remain to be developed.

Filamentary streamer discharges in argon at atmospheric pressure excited by surface plasmon polaritons.

This paper describes a microwave plasma jet in an argon atmosphere capable of generating filamentary streamer discharges within the entire quartz tube excited by surface waves of surface plasmon polaritons (SPPs) located in the tube. Several discharge streamers are immediately produced at the end of the copper wire when incident power reaches 20 W. From simulations, the wavelength of the surface wave was found to be approximately 5.

[The research of the correlation of obstructive sleep apnea-hypopnea syndrome and insulin resistance].

Objective: To investigate whether obstructive sleep apnea-hypopnea syndrome (OSAHS) is relevant to insulin resistance (IR) and whether it is an independent factor of IR.

Method: Forty-eight OSAHS patients (OSAHS group) excluding obesity, high blood sugar, high blood fat and hypertension and 45 health adults without OSAHS (control group) were included in this research. The sleeping parameters such as AHI, AI, SIT90, IAT, MSaO2, LSaO2, etc.