Publications by authors named "Zhaoming Ge"

Background: Chronic migraine (CM) is a serious neurological disorder. Central sensitization is one of the important pathophysiological mechanisms underlying CM, and microglia-induced neuroinflammation conduces to central sensitization. Triggering receptor expressed on myeloid cells 2 (TREM2) is presented solely in microglia residing within the central nervous system and plays a key role in neuroinflammation.

View Article and Find Full Text PDF

: Extracorporeal life support echniques as an Adjunct to Advanced Cardiac Life Support is usually suitable for complex heart surgery such as cardiopulmonary bypass (CPB). Cerebral perfusion is a clinically feasible neuroprotective strategy; however, the lack of a reliable small animal model.: Based on the rat model of ECLS we evaluate the effects of ECLS-CP using HE staining, Nissl staining, TUNEL staining and ELISA.

View Article and Find Full Text PDF

Hydrogen-bonded organic frameworks (HOFs) are outstanding candidates for photocatalytic hydrogen evolution. However, most of reported HOFs suffer from poor stability and photocatalytic activity in the absence of Pt cocatalyst. Herein, a series of metal HOFs (Co-HOF-X, X=COOMe, Br, tBu and OMe) have been rationally constructed based on dinuclear cobalt complexes, which exhibit exceptional stability in the presence of strong acid (12 M HCl) and strong base (5 M NaOH) for at least 10 days.

View Article and Find Full Text PDF
Article Synopsis
  • - DMSC (dinuclear metal synergistic catalysis) is a promising method to boost the efficiency of photocatalytic CO reduction, but designing effective dinuclear metal complexes has been challenging due to a lack of understanding of their microenvironment's impact on catalytic activity.
  • - A new dinuclear cobalt complex with a planar structure has been developed, demonstrating exceptional catalytic performance for converting CO, achieving turnover numbers (TON) and turnover frequencies (TOF) that are significantly higher than those of a corresponding single-metal complex.
  • - The enhanced activity of this dinuclear cobalt complex is attributed to an indirect DMSC effect between the two cobalt ions, facilitating an efficient two-electron transfer process and improved mass transfer, all supported by its unique planar design
View Article and Find Full Text PDF
Article Synopsis
  • Neuroinflammation, driven by microglial activation and TREM1 receptors, plays a significant role in chronic migraine development, yet the specific relationship between TREM1 and chronic migraine remains unclear.
  • The study utilized a nitroglycerin-induced model to evaluate the impact of TREM1 and the NF-κB pathway on pain sensitivity and inflammatory responses, utilizing various techniques like Western blotting and immunofluorescence to assess cellular behaviors.
  • Results showed that TREM1 expression increased in microglia following nitroglycerin treatment, and targeting TREM1 and NF-κB with specific inhibitors effectively reduced pain symptoms and inflammation in the chronic migraine model.
View Article and Find Full Text PDF

Central sensitization is an important pathophysiological mechanism underlying chronic migraine (CM). Previous studies have shown that microglial activation and subsequent inflammation in the trigeminal nucleus caudalis (TNC) contribute to central sensitization. Toll-like receptor 2 (TLR2) is a receptor expressed on the membrane of microglia and participates in central sensitization in inflammatory and chronic pain; however, its role in CM is unclear.

View Article and Find Full Text PDF

Background: Acute ischemic stroke (AIS) is the leading cause of morbidity and mortality among cerebrovascular diseases. While animal studies have suggested a correlation between cold-inducible RNA-binding protein (CIRP) serum levels and the severity and prognosis of cerebral infarction, there has been a lack of research exploring this association in humans with cerebral infarction.

Materials And Methods: A total of 148 patients diagnosed with AIS within 7 days from symptom onset were included in this study.

View Article and Find Full Text PDF

Non-cardioembolic ischemic stroke (IS) is the predominant subtype of IS. This study aimed to construct a nomogram for recurrence risks in patients with non-cardioembolic IS in order to maximize clinical benefits. From April 2015 to December 2019, data from consecutive patients who were diagnosed with non-cardioembolic IS were collected from Lanzhou University Second Hospital.

View Article and Find Full Text PDF

Compared with conventional cardiopulmonary resuscitation (CCPR), extracorporeal cardiopulmonary resuscitation (ECPR) can improve the survival rate of patients with cardiac arrest, and reduce the risk of reperfusion injury. However, it is still difficult to avoid the risk of secondary brain damage. Low temperature management has good neuroprotective potential for ECPR patients, which minimizes brain damage.

View Article and Find Full Text PDF

An ischemic stroke occurs when the blood supply is obstructed to the vascular basin, causing the death of nerve cells and forming the ischemic core. Subsequently, the brain enters the stage of reconstruction and repair. The whole process includes cellular brain damage, inflammatory reaction, blood-brain barrier destruction, and nerve repair.

View Article and Find Full Text PDF

. This study focuses on the identification of risk factors, classification of stroke level, and evaluation of the importance and interactions of various patient characteristics using cohort data from the Second Hospital of Lanzhou University. .

View Article and Find Full Text PDF
Article Synopsis
  • Migraine is a complex neurological condition influenced by genetic and environmental factors, and its persistent pain may be linked to immune and inflammatory systems involving Toll-like receptors (TLRs).
  • TLRs play a critical role in the innate immune response by initiating inflammation when tissues are damaged or stressed, and their activation in the brain can affect pain processing through interactions with glial cells and neurons.
  • Understanding the role of TLRs in migraine could lead to new, more effective treatments for chronic migraines, as current options are often inadequate.
View Article and Find Full Text PDF
Article Synopsis
  • Paraneoplastic neurological syndrome (PNS) is a rare cancer-related complication that can impact various parts of the nervous system, causing diverse neurological symptoms, with certain antibody types frequently involved.* -
  • A 55-year-old woman with a history of breast cancer was found to have small-cell lung cancer and exhibited unusual neurological symptoms associated with both anti-Yo and anti-Hu antibodies, marking a rare case of concurrent paraneoplastic conditions.* -
  • This case highlights the need for increased awareness regarding the occurrence of multiple tumors and corresponding paraneoplastic antibodies in patients, as it may complicate diagnosis and treatment.*
View Article and Find Full Text PDF

Objective: The purpose of the study was to investigate the clinical effect of high-dose glucocorticoids (GCS) combined with immunosuppressants on the treatment of myasthenia gravis (MG) with video-assisted thoracoscopic surgery (VATS).

Methods: A total of 106 MG patients admitted to the neurology department of our hospital from February 2016 to February 2020 were selected as the study subjects and divided into experimental group ( = 53) and control group ( = 53). The patients in the control group underwent VATS, while the patients in the experimental group were treated with high-dose GCS combined with immunosuppressants on the basis of VATS treatment.

View Article and Find Full Text PDF

To investigate the correlation between serum renin-angiotensin system (RAS) level and Symptoms of anxiety and depression in Parkinson disease patients (PD). A number of 90 PD patients (47 males and 43 females) were collected on an empty stomach 12 h after stopping taking anti-PD medicines. ELISA has been found in Serum RAS ((Ang) I, Ang II, Ang (1-7), Angiotensin converting enzyme (ACE), ACE2).

View Article and Find Full Text PDF
Article Synopsis
  • The link between diabetes and Alzheimer's disease (AD) involves hyperphosphorylation of tau protein, which is influenced by CDK5 levels that may increase due to diabetes-related hyperglycemia.
  • In a study with rats, those induced with diabetes showed worse behavior and changes in the CDK5 promoter, suggesting that diabetes negatively impacts cognitive function.
  • Inhibiting a specific acetyltransferase reduced CDK5 activation and tau phosphorylation, leading to improved behavior in rats, indicating that diabetes may contribute to AD development through histone modifications.
View Article and Find Full Text PDF

Many Alzheimer's disease (AD) patients suffer from persistent neuropathic pain (NP), which is mediated, at least partially, but microglia. Nevertheless, the exact underlying mechanism is unknown. Moreover, a clinically translatable approach through modulating microglia for treating AD-associated NP is not available.

View Article and Find Full Text PDF

Multiple microRNAs (miRs) have also been implicated in ischemic brain injury. This research intended to probe the regulatory function and the mechanism of miR-15a on the ischemic brain injury induced by oxygen-glucose deprivation/reoxygenation (OGD/R) in neurons of rats. The OGD/R model was established with the cortical neurons separated from rats.

View Article and Find Full Text PDF

We aimed to assess the possible relations between serum levels of macrophage migration inhibitory factor (MIF), a central cytokine of the innate immunity and inflammatory response, and benign paroxysmal positional vertigo (BPPV) risk and BPPV recurrence events. In the present study, 154 patients with BPPV, and 100 age-and sex-matched control subjects were enrolled in the study. All the patients and controls underwent a complete audio-vestibular test battery including the Dix-Hallpike maneuver and supine roll test.

View Article and Find Full Text PDF

Cyclin-dependent kinase-5 (CDK5) is activated by p35 and then binds to both p35 and its truncated form p25 to promote hyperphosphorylation of tau protein, thereby facilitating the pathological progression of Alzheimer's disease (AD). However, it is unknown whether a patient's diabetic status promotes the later onset of AD in a CDK5-dependent manner. Here, we induced pro-diabetic insulin resistance and glucose intolerance in rats using a combined high fat and high glucose diet.

View Article and Find Full Text PDF

Background: Granulocyte colony-stimulating factor (G-CSF) has been shown to reduce lesion volume and improve functional outcome in experimental stroke models. However, whether G-CSF plays a role currently in patients with stroke remains uncertain. Our study aimed at examining the efficacy and safety of G-CSF in patients with acute ischemic stroke.

View Article and Find Full Text PDF