Publications by authors named "Zhaolu Wang"

Article Synopsis
  • ICAS is a common cause of stroke and asymptomatic ICAS is linked to a higher risk of future strokes, despite current treatments.
  • This study aims to assess the effectiveness of alirocumab, combined with statin therapy, in stabilizing intracranial plaques in patients with asymptomatic ICAS using high-resolution MRI.
  • The trial will involve 80 patients, is ethically approved, and results will be shared in peer-reviewed journals.
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Metamaterials have demonstrated significant potential for enhancing nonlinear processes at the nanoscale. The presence of narrowband hot-spots and highly inhomogeneous mode-field distributions often limit the enhancement of nonlinear interactions over larger spatial scales. This has posed a formidable challenge in achieving simultaneous enhancement across a broadband spectral range, significantly constraining the potential of photonic nanostructures in enhancing nonlinear frequency conversion.

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Confined evaporation-induced self-assembly (C-EISA) is a powerful technique to guide disordered nanoparticles into long-range organized structures. Herein, we investigate the C-EISA behavior of 1-butyl-3-vinylimidazolium cation ([VBIm]) grafted cellulose nanocrystals (CNC-C) in a parallel-plates confined geometry. Interestingly, CNC-C can spontaneously assemble into maze-like patterns with branch dimensions on the micrometer scale and uniformly distributed throughout the confined space, which is completely different from the lamellar self-assembly patterns of unmodified CNCs.

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Background: Currently, ischemic stroke is the leading cause of death in China. To compare regional differences of ischemic stroke, we analyzed the clinical characteristics of patients with ischemic stroke in four regionally representative hospitals in China.

Methods: We conducted a retrospective study at four tertiary hospitals in east China, with regionally representative patients.

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Pearlescent materials are of technological importance in a diverse array of industries from cosmetics to premium paints; however, chiral pearlescent materials remain unexplored. Here, chiral pearlescent films with on-demand iridescence and metallic appearance are simply organized by leveraging vertical pressure to direct the self-assembly of cellulose nanocrystals. The films are formed with a bilayer planar anchored left-handed chiral nematic architecture, in which the bottom layer is featured with a vertical gradient pitch, and the top layer is featured with a uniform pitch.

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Intramuscular fat (IMF) positively influences various aspects of meat quality, while the subcutaneous fat (SF) has negative effect on carcass characteristics and fattening efficiency. Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of adipocyte differentiation, herein, through bioinformatic screen for the potential regulators of adipogenesis from two independent microarray datasets, we identified that PPARγ is a potentially regulator between porcine IMF and SF adipogenesis. Then we treated subcutaneous preadipocytes (SA) and intramuscular preadipocytes (IMA) of pig with RSG (1 µmol/L), and we found that RSG treatment promoted the differentiation of IMA via differentially activating PPARγ transcriptional activity.

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An analytical method is proposed in this paper to achieve complete energy conversion in sum frequency generation based on the Lewis-Riesenfeld invariants theory. In the proposed scheme, a quasi-adiabatic single control parameter model is established, and the value of single control parameter is selected to make the initial eigenstate perfectly converted to the final eigenstate as needed. Corresponding to the nonlinear frequency conversion process, a nonlinear crystal structure is designed by inverse engineering using the optimal control theory.

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Skeletal muscle plays a paramount role in physical activity, metabolism, and energy balance, while its homeostasis is being challenged by multiple unfavorable factors such as injury, aging, or obesity. Exosomes, a subset of extracellular vesicles, are now recognized as essential mediators of intercellular communication, holding great clinical potential in the treatment of skeletal muscle diseases. Herein, we outline the recent research progress in exosomal isolation, characterization, and mechanism of action, and emphatically discuss current advances in exosomes derived from multiple organs and tissues, and engineered exosomes regarding the regulation of physiological and pathological development of skeletal muscle.

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We propose a near-infrared (NIR) image reconstruction method based on molecular reorientation of nematic liquid crystals (NLCs) doped with the azo-dye methyl red (MR). The signal can be recovered at the expense of noise via stochastic resonance. The numerical results show that image reconstruction based on the molecular reorientation in a magnetic field can be achieved when the input light intensity is 0.

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We investigate the third-order nonlinear optical properties of epsilon-near-zero (ENZ) Au/dye-doped fused silica multilayered metamaterials in the visible spectral range for TM incident by using nonlocal effective medium theory at different incidence angles. The nonlocal response affects the permittivity of anisotropic metamaterials when the thickness of the layer cannot be much smaller than the incident wavelength. By doping pump dye gain material within the dielectric layer to compensate for the metal loss, the imaginary part of the effective permittivity is reduced to 10, and the optical nonlinear refractive index and nonlinear absorption coefficient are enhanced.

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Background: Syncope is common, but there is no clear cause for half of the patients diagnosed with syncope. Although suspected, there is limited evidence that right-to-left shunt (RLS) is related to syncope. This matched case-control study investigated the association between RLS (exposure) and unexplained syncope (outcome).

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The aim of this study is to measure the output factor (OF) and profile of surface dose in regular and small radiation therapy fields using Cherenkov imaging (CI). A medical linear accelerator (linac) was employed to generate radiation fields, including regular open photon field (ROPF), regular wedge photon field (RWPF), regular electron field (REF) and small photon field (SPF). The photon beams consisted of two filter modes including flattening filter (FF) and flattening filter free (FFF).

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The nonlinear optical response of common materials is limited by bandwidth and energy consumption, which impedes practical application in all-optical signal processing, light detection, harmonic generation, etc. Additionally, the nonlinear performance is typically sensitive to polarization. To circumvent this constraint, we propose that orthogonal nanoantennas coupled to Al-doped zinc oxide (AZO) epsilon-near-zero (ENZ) material show a broadband (~1000 nm bandwidth) large optical nonlinearity simultaneously for two orthogonal polarization states.

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We propose a near-infrared image recovery method based on modulation instability in the photorefractive semiconductor CdZnTe:V. The formation mechanism of modulation instability in CdZnTe:V is discussed, and the theoretical gain model is derived. Theoretical results of optical image recovery at 1 µm and 1.

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We theoretically propose the magneto-optically reorientation-induced image reconstruction in bulk nematic liquid crystals (NLCs). The underlying signals are reinforced and recovered at the expense of scattering noise under reorientation-induced self-focusing nonlinearity. The intensity perturbation gain is derived and the numerical results are presented to show the response of NLC molecules to the diffusive images.

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The coherent Ising machine (CIM) implemented by degenerate optical parametric oscillator (DOPO) networks is a novel optical platform to accelerate computation of hard combinatorial optimization problems. Nevertheless, with the increase of the problem size, the probability of the machine being trapped by local minima increases exponentially. According to the quantum adiabatic theorem, a physical system will remain in its instantaneous ground state if the time-dependent Hamiltonian varies slowly enough.

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Background: Stroke not only substantially increases the risk of incident dementia early after stroke but also the risk remains elevated years after.

Aim: We aimed to determine the risk factors of dementia onset more than three to six months after stroke or transient ischemic attack.

Methods: This is a single-center prospective cohort study.

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Cerenkov emission during electron radiotherapy had been emerging as a new dose assessment approach for clinical radiotherapy and could be imaged through a standard commercial camera. The purpose of this work aimed to study the accuracy of corrected Cerenkov emission method during electron radiotherapy by Monte Carlo (MC) method. GAMOS MC software was used to model the physics of electron therapy and calculated dose and Cerenkov photon distribution in water phantom.

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Significance: Due to patients' respiratory movement or involuntary body movements during breast cancer radiotherapy, the mismatched adjacent fields in surface exposure regions could result in insufficient dosage or overdose in these regions, which would lead to tissue injury, excessive skin burns, and potential death. Cherenkov luminescence imaging (CLI) could be used to effectively detect the matching information of adjacent radiation fields without extra radiation or invasive imaging.

Aim: Our objective was to provide a biological experimental basis for monitoring matching of adjacent radiation fields between photon and electron fields due to introduced shifts during radiotherapy by CLI technique.

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A fluorescence ratio sensor based on dansyl-peptide, Dansyl-Glu-Cys-Glu-Glu-Trp-NH (D-P5), was efficiently synthesized by Fmoc solid phase peptide synthesis. The sensor exhibits high selectivity and sensitivity for Ag over 16 metal ions in 100 mM sodium perchlorate and 50 mM 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid buffer solution by fluorescence resonance energy transfer. The 1:1 binding stoichiometry of the sensor and Ag is measured by fluorescence ratio response and the job's plot.

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The fermented feed has been identified as a potential alternative to antibiotics in feeds that markedly affects gut health and growth performance of pigs. Two recent studies performed in our laboratory investigated that the fermented corn-soybean meal (fermented feed, FF) improved the gut health of pigs. This study was conducted to determine the effect of a FF on the carcass, meat quality, muscle fatty acids profile, muscle amino acid and antioxidant ability of grower-finisher pigs.

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To produce functional cellulose nanocrystal (CNC) films with desirable optical and mechanical properties, it is critical to understand and control the chiral self-assembly of CNCs during solvent removal. Here, the formation mechanism of CNC chiral nematic liquid crystal phase during vacuum-assisted self-assembly (VASA) was investigated. To elucidate the structural evolution of CNC aggregations on filter paper, CNC suspensions were "frozen" at various filtration stages in a polyacrylamide matrix.

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This study was conducted to determine the effect of a fermented corn-soybean meal [fermented feed (FF)] on the gene expression of immunity in the blood, the level of secretory immunoglobulin A (sIgA), and mucosa-associated bacterial community in the duodenum and colon of grower-finisher pigs. In this study, crossbred barrows (Duroc × Landrace × Large White) were randomly assigned to either an unfermented corn-soybean diet (Ctrl) ( = 6) or an FF diet ( = 6), and then the following were examined: the expression of immunity using real-time reverse transcription polymerase-chain reaction in the blood, sIgA using enzyme-linked immunosorbent assay (ELISA), and changes in the bacterial community using Illumina Hiseq sequencing in the mucosa of the duodenum and colon. Compared with control pigs fed with a standard diet, the results showed that FF caused upregulation of the mRNA expression of Toll-like receptor 3 (TLR3), TLR4, TLR6, and TLR8 in the blood ( < 0.

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Background: The latest evidence shows the association of atrial cardiopathy with embolic strokes of undetermined source. Advanced interatrial block (aIAB) is an electrophysiological mark of atrial cardiopathy. This study investigated the relationship between aIAB and the burden of silent cerebral small vessel diseases (SVD) on magnetic resonance imaging in the absence of atrial fibrillation (AF) and atrial flutter.

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