Targeting ALDH1A1 to enhance the efficacy of KRAS-targeted therapy through ferroptosis.

KRAS is among the most commonly mutated oncogenes in human malignancies. Although the advent of sotorasib and adagrasib, has lifted the "undruggable" stigma of KRAS, the resistance to KRAS inhibitors quickly becomes a major issue. Here, we reported that aldehyde dehydrogenase 1 family member A1 (ALDH1A1), an enzyme in retinoic acid biosynthesis and redox balance, increases in response to KRAS inhibitors and confers resistance in a range of cancer types.

Targeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma.

Ferroptosis is a regulated cell death driven by iron-dependent lipid peroxidation and associated with drug resistance in lung adenocarcinoma (LUAD). It's found that aldehyde dehydrogenase 2 (ALDH2), which is highly mutated in East Asian populations, is correlated with response to chemotherapy in LUAD patients. The rs671 variant knock-in, downregulation, and pharmacological inhibition of ALDH2 render LUAD cells more vulnerable to ferroptosis inducers and platinum-based chemotherapy.

Fast lightweight framework for time-of-flight super-resolution based on block compressed sensing.

Compressive time-of-flight (ToF) imaging for super-resolution (SR) has tremendous development potential owing to its cost-effectiveness and simplicity. However, existing compressive ToF methods are difficult to apply in practical situations because of their low efficiency and high data storage requirements. In this paper, we propose a fast and lightweight compressive ToF framework for SR.

A systematic non-uniformity correction method for correlation-based ToF imaging.

Correlation-based time-of-flight (ToF) imaging enables a diverse range of applications for its high frame rate, high resolution and low cost. However, the non-uniformity of the sensor significantly affects the flat-field accuracy of the ToF imaging system. In this paper, we analyze the sources of the non-uniformity and propose a systematic non-uniformity correction (NUC) method.