Tnfaip6 Secreted by Bone Marrow-Derived Mesenchymal Stem Cells Attenuates TNBS-Induced Colitis by Modulating Follicular Helper T Cells and Follicular Regulatory T Cells Balance in Mice.

To investigate the immunological mechanism of bone marrow-derived mesenchymal stem cells (BM-MSCs) in inflammatory bowel disease (IBD). Mice with 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis were intraperitoneally injected with phosphate-buffered saline, BM-MSCs, BM-MSCs with tumor necrosis factor-induced protein 6 (Tnfaip6) knockdown mediated by RNA interference recombinant adenovirus, and BM-MSCs-infected with control adenovirus or recombinant mouse Tnfaip6. The disease activity index, weight loss, and histological scores were recorded.

Status epilepticus increases mature granule cells in the molecular layer of the dentate gyrus in rats.

Enhanced neurogenesis in the dentate gyrus of the hippocampus following seizure activity, especially status epilepticus, is associated with ectopic residence and aberrant integration of newborn granule cells. Hilar ectopic granule cells may be detrimental to the stability of dentate circuitry by means of their electrophysiological properties and synaptic connectivity. We hypothesized that status epilepticus also increases ectopic granule cells in the molecular layer.

Distribution and neurochemical features of neuronal nitric oxide synthase-expressing interneurons in the rat dentate gyrus.

Neuronal nitric oxide synthase (nNOS)-expressing interneurons are abundant in the dentate gyrus (DG) of rodents. In the present study, we immunohistochemically analyzed nNOS-positive cells in the rat DG by focusing on their GABAergicity, laminar distribution, and co-localization with calcium-binding proteins and neuropeptides. Experiments were conducted in adult male Sprague Dawley rats.