Effect of landfill age on the physical and chemical characteristics of waste plastics/microplastics in a waste landfill sites.

The landfills store a lot of waste plastics, thus it has been confirmed a main source for the occurrence of plastics/microplastic. Although there are some reports that microplastics (MPs) can generate in leachate and refuse samples from the landfill, it exist many blanks for the evolution of physical and chemical characteristics of waste plastics and microplastics with different landfill age. To explore the process that large pieces of plastic are fractured into microplastics, the waste plastics with landfill age from 7 to 30 years are surveyed from a typical landfill in Shanghai.

Copper mediated molecularly imprinted polymers for fast recognizing tylosin.

As one kind of artificial antibody, molecularly imprinted polymers (MIPs) has been widely used to separate/enrich target molecules from samples with the complex matrix prior to instrumental analysis. In this work, one novel copper mediated magnetic MIPs was developed towards anti-bacteria macrolide antibiotic tylosin (TYL). The obtained microspheres had a lot of convexities distributed evenly on the surface.

[Preparation of molecularly imprinted polymers based on covalent organic frameworks and their application to selective recognition of trace norfloxacin in milk].

Norfloxacin (NFX) is an antibiotic that is widely used in animal husbandry. However, the presence of NFX even in trace amounts in animal-derived food may harm human health. Therefore, it is of practical significance to establish a method for monitoring NFX residues in food.

Facile Way to Prepare a Porous Molecular Imprinting Lock for Specifically Recognizing Oxytetracyclin Based on Coordination.

Molecularly imprinted polymers (MIPs) are a kind of synthetic receptor-like materials. They have drawn more and more attention in the past decades. In this work, a facile method was developed to prepare porous magnetic MIPs utilizing metal coordination.

Targets of biologic disease-modifying antirheumatic drugs and risk of multiple myeloma.

Several commonly used immune-suppressing biologic drugs target proteins and cytokines involved in myeloma pathogenesis. Our objective was to determine whether targeted biologic disease-modifying antirheumatic drugs (DMARDs) are associated with risk of multiple myeloma (MM). We conducted a nested case-control study within a retrospective cohort of 56,886 commercially insured adults undergoing treatment for rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis between 2009 and 2015 using the Truven Health MarketScan Databases.

Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma.

Background: Granulocyte colony-stimulating factors (G-CSFs), which are used for the prevention of complications from chemotherapy-related neutropenia, are linked to the risk of developing second primary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The objective of this study was to examine the correlation between using a specific G-CSF agent and the risk of MDS/AML among older patients with non-Hodgkin lymphoma (NHL).

Methods: This was a retrospective cohort study of adults aged >65 years who were diagnosed with first primary NHL between 2001 and 2011.

Tumor necrosis factor-alpha inhibitors and risk of non-Hodgkin lymphoma in a cohort of adults with rheumatologic conditions.

Based on limited evidence, the U.S. Food and Drug Administration (FDA) issued a black box warning for the use of tumor necrosis factor-alpha inhibitors (TNFIs) and risk of non-Hodgkin lymphoma (NHL).

Autophagy pathway is required for IL-6 induced neuroendocrine differentiation and chemoresistance of prostate cancer LNCaP cells.

Prostate cancer (PCa) cells undergoing neuroendocrine differentiation (NED) are clinically relevant to the development of relapsed castration-resistant PCa. Increasing evidences show that autophagy involves in the development of neuroendocrine (NE) tumors, including PCa. To clarify the effect of autophagy on NED, androgen-sensitive PCa LNCaP cells were examined.

Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.

There is overwhelming evidence that tyrosine kinases play an important role in cancer development. As a prototype of targeted therapy, tyrosine kinase inhibitors are now successfully applied to cancer treatment. However, as single agents, tyrosine kinase inhibitors have not achieved satisfactory results in the treatment of prostate cancer, principally due to their inability to efficiently kill tumor cells.

Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2.

Soluble epoxide hydrolase (sEH) is a multifunctional protein encoded by the EPHX2 gene. The biological functions and enzyme kinetics of sEH have been extensively investigated, however, little is known about its transcriptional regulation and mechanisms of tissue specific expression. Here, a luciferase gene based reporter assay was used to identify the minimal promoter and cis regulatory elements of EPHX2.